Computerized corneal topography in a paediatric population with Down syndrome

Vincent, Andrea L; Weiser, Brent A; Cupryn, Monique; Stein, Raymond; Abdolell, Mohamed; Levin, Alex V.

doi:10.1111/j.1442-9071.2005.00941.x

Cited by 35 publications

(28 citation statements)

References 20 publications

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“…They include Down syndrome, 56,57 Leber's congenital amaurosis 41,58,59 and some connective tissue and collagen disorders, such as EhlersDanlos syndrome, 60 Marfan syndrom 61,62 and osteogenesis imperfecta. 63 These associations add further support for a genetic contribution to the disease and could potentially provide information on chromosomal loci.…”

Section: Association Studiesmentioning

confidence: 99%

The Epidemiology and Etiology of Keratoconus

Gordon‐Shaag¹,

Millodot²,

Shneor³

2012

International Journal of Keratoconus and Ectatic Corneal Diseases

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Keratoconus is a noninflammatory disorder characterized by ectasia of the central or inferior portion of the cornea. This review presents the scant epidemiological information known to date and the factors believed to cause the development of the disease. They are the genetic factors for which evidence come from family studies, twin studies and genetic loci. There appears to be multiple genes causing a keratoconus phenotype with variable penetration. However, the genetic predisposition might not be enough; environmental factors, such as eye rubbing, atopy and UV exposure, may have a role in generating the disease.

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Section: Association Studiesmentioning

confidence: 99%

The Epidemiology and Etiology of Keratoconus

Gordon‐Shaag¹,

Millodot²,

Shneor³

2012

International Journal of Keratoconus and Ectatic Corneal Diseases

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“…DS is a genetic condition associated with both structural and functional abnormalities. Several studies have reported that the eyes of individuals with DS have structural differences compared to aged matched populations without DS, such as thinner and steeper corneas, 2–4 which may contribute to the observed higher incidence of refractive error, 5, 6 as well as higher levels of astigmatism. 3, 4, 7–10 Many studies have also reported a higher prevalence of KC in individuals with DS, 11, 12 but it is not known if the structural differences in their thinner, more astigmatic corneas simply mimic KC, represent an incomplete (form fruste) KC, or is a truly progressive form of the disease.…”

mentioning

confidence: 99%

Simulated Keratometry Repeatability in Subjects with and without Down Syndrome

et al. 2016

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Purpose To assess the repeatability of simulated keratometry measures obtained with Zeiss Atlas topography for subjects with and without Down syndrome (DS). Methods Corneal topography was attempted on 140 subjects with DS and 138 controls (aged 7 to 59 years). Subjects who had at least 3 measures in each eye were included in analysis (DS: n=140 eyes (70 subjects) and controls: n=264 eyes (132 subjects)). For each measurement the steep corneal power (K), corneal astigmatism, flat K orientation, power vector representation of astigmatism (J0, J45), and astigmatic dioptric difference were determined for each measurement (collectively termed keratometry values here). For flat K orientation comparisons, only eyes with >0.50 DC of astigmatism were included (DS: n=131 eyes (68 subjects) and control: n=217 eyes (119 subjects)). Repeatability was assessed using 1) group mean variability (average standard deviation (SD) across subjects), 2) coefficient of repeatability (COR) 3) coefficient of variation (COV), and 4) intraclass correlation coefficient (ICC). Results The keratometry values showed good repeatability as evidenced by low group mean variability for DS vs control eyes (≤0.26D vs ≤0.09D for all dioptric values; 4.51° vs 3.16° for flat K orientation); however, the group mean variability was significantly higher in DS eyes than control eyes for all parameters (p≤0.03). On average, group mean variability was 2.5× greater in the DS eyes compared to control eyes across the keratometry values. Other metrics of repeatability also indicated good repeatability for both populations for each keratometry value, although repeatability was always better in the control eyes. Conclusions DS eyes showed more variability (on average: 2.5×) compared to controls for all keratometry values. Although differences were statistically significant, on average 91% of DS eyes had variability ≤0.50D for steep K and astigmatism, and 75% of DS eyes had variability ≤5 degrees for flat K orientation.

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“…Although some authors have attributed the high prevalence of keratoconus in patients with DS to chronic eye rubbing (4,6), others have not (22). Some researchers have concluded that there are genetic aspects of the disease.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of early corneal topographic changes in children with Down syndrome

Aslankurt¹,

Aslan²,

Aksoy³

et al. 2013

Turk J Med Sci

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Two new rotaliid genera and three new species are described from the Upper Ypresian of Sicily and Central Italy: Ornatorotalia spinosa n. gen. n. sp., Ornatorotalia granum n. sp. and Granorotalia sublobata n. gen. n. sp. Th e new taxa are all dated as SBZ 11 (middle Upper Ypresian, i.e., middle Cuisian) by the presence of Cuvillierina vallensis and alveolinid biostratigraphical markers such as Alveolina cremae, A. decastroi and A. distefanoi. Th e systematic position of these distinctive new taxa within the family Rotaliidae Ehrenberg, 1839 and their biostratigraphic potential are discussed.

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Computerized corneal topography in a paediatric population with Down syndrome

Cited by 35 publications

References 20 publications

The Epidemiology and Etiology of Keratoconus

The Epidemiology and Etiology of Keratoconus

Simulated Keratometry Repeatability in Subjects with and without Down Syndrome

Evaluation of early corneal topographic changes in children with Down syndrome

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