Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis

Hill, Nicole T. M.; Mowszowski, Loren; Naismith, Sharon L.; Chadwick, Verity; Valenzuela, Michael; Lampit, Amit

doi:10.1176/appi.ajp.2016.16030360

Cited by 567 publications

(562 citation statements)

References 65 publications

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“…APOE 4 carriers did not show any benefit from training in this domain. These findings are completely consistent with those recently obtained by Hill et al [71]. However, considering that this scale is mainly used for screening, we must be cautious when interpreting this collateral training effect on mood, as all subjects had normal scores on the GDS-15 (that is, between 0 and 5).…”

Section: Discussionsupporting

confidence: 91%

APOE ε4 Modulation of Training Outcomes in Several Cognitive Domains in a Sample of Cognitively Intact Older Adults

López-Higes

Rodríguez-Rojo

Prados

et al. 2017

JAD

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Abstract.Background: Most research points to the 4 allele of the apolipoprotein E (APOE) gene as the most recognizable genetic risk factor associated with Alzheimer's disease pathogenesis. It has been also suggested that the APOE 4 allele has a negative influence on cognitive functioning, which begins long before cognitive impairment becomes manifest. However, still, little is known about the APOE 4 interaction with cognitive intervention programs. Objective: The main goal of this study was to explore whether there was a differential APOE genotype modulation effect after cognitive training in different domains, such as language comprehension, executive functions, and memory. Contrary to other studies, hippocampal volume was controlled for. Methods: Fifty older adults (65+ years; 30 women and 20 men) participated in a multi-domain cognitive training that involved 30 sessions taking place over 12 weeks. Half of the participants were APOE 4 carriers. The control group was matched in age, gender, normalized hippocampal volume, cognitive reserve, Mini-Mental State Examination score, and Geriatric Depression Scale-Short Version. Results: The study revealed that there were consistent treatment benefits in complex sentence comprehension (noncanonical sentences and sentences with two propositions), a domain that was not directly trained, but only in the APOE 4 noncarrier group. Conclusion: Genetic profile modulates training outcomes in sentence comprehension.

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Section: Discussionsupporting

confidence: 91%

APOE ε4 Modulation of Training Outcomes in Several Cognitive Domains in a Sample of Cognitively Intact Older Adults

López-Higes

Rodríguez-Rojo

Prados

et al. 2017

JAD

View full text Add to dashboard Cite

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“…However, these analyses were underpowered due to the small number of studies. Interestingly, other recent meta-analyses have noted that effects of CT are not greater relative to nocontact vs. active control conditions (Hill et al 2016). At the same time, if beliefs or expectations of improvement were driving cognitive training effects, then various types of cognitive training would show similar performance improvements, which is clearly not the case.…”

Section: Discussionmentioning

confidence: 90%

Systematic Literature Review and Meta-Analysis of Commercially Available Computerized Cognitive Training Among Older Adults

Tetlow

Edwards

2017

J Cogn Enhanc

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Researchers have explored a variety of interventions to improve cognition among older adults. One of which is computerized cognitive training programs. The number of commercially available, cognitive training programs has increased greatly, but scientists debate their value. The purposes of this systematic literature review and meta-analysis were to (1) evaluate the efficacy of commercially available, computerized cognitive training programs to improve cognition in older adults and (2) examine far transfer of training to untrained tasks relevant to everyday functioning. Articles were reviewed if the study (a) included a sample of adults aged 55 and older, (b) used a commercially available, computerized cognitive training program, (c) was a randomized controlled trial, (d) measured cognition as an outcome, and (e) included a sample that was free from health conditions affecting cognitive function (e.g., cancer, stroke, psychiatric conditions, or traumatic brain injury). Effect sizes were calculated using random effect models to determine cognitive training effects for various cognitive domains and far transfer tasks. There were significant small to medium training effects for the cognitive domains of attention (d = 0.651, p < .001), processing speed (d = 0.294, p = .002), and visuospatial memory (d = 0.252, p = 0.016). There was also evidence of far transfer to selfreported measures of everyday function (d = 0.277, p < 0.001). Commercially available computerized cognitive training programs may improve certain cognitive abilities among older adults, who also report improvement on tasks relevant to their everyday lives.

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“…Woods et al 2012;van Nes, 2013;Genoe & Dupuis, 2014;Hill et al 2017;Mondini et al 2016;Spector et al, 2017 Individual activities Individual activities as a source to gain strength and to nurture social relationships.…”

Section: Methodsmentioning

confidence: 99%

Living Life and Doing Things Together: Collaborative Research With Couples Where One Partner Has a Diagnosis of Dementia

et al. 2018

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The aim of this study is to identify relevant content for a self-management guide by using the outcomes of previous research in combination with knowledge and experiences from couples where one partner has a diagnosis of dementia. The study was carried out in three phases: 1) Literature search of previous research related to wellbeing and couplehood in dementia; 2) Interviews with couples with dementia based on the findings of the literature search; 3) Further authentication of the findings within expert groups of people with dementia and carers. For analysis of data we used a hybrid approach of thematic analysis with combined deductive and inductive approaches. The findings of this study indicated that the four main themes "Home and Neighborhood", "Meaningful activities and Relationships", "Approach and Empowerment" and "Couplehood" with related sub themes could be appropriate targets for a self-management guide for couples where one partner has a diagnosis of dementia.

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Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis

Cited by 567 publications

References 65 publications

APOE ε4 Modulation of Training Outcomes in Several Cognitive Domains in a Sample of Cognitively Intact Older Adults

APOE ε4 Modulation of Training Outcomes in Several Cognitive Domains in a Sample of Cognitively Intact Older Adults

Systematic Literature Review and Meta-Analysis of Commercially Available Computerized Cognitive Training Among Older Adults

Living Life and Doing Things Together: Collaborative Research With Couples Where One Partner Has a Diagnosis of Dementia

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