Computed tomography has proved very valuable in the diagnosis of central nervous system changes in tuberous sclerosis. A full analysis of the CT findings in 34 cases is presented. Intracranial calcifications--periventricular, corticosubcortical, within the white substance or in the posterior cranial fossa--were the most frequent finding, followed by parenchymal hypodensities and tumors. Hydrocephalus and atrophy, focal or diffuse, were rare.