Computerized ambulatory esophageal pH monitoring in 50 asymptomatic volunteer subjects

Cheadle, William G.; Vitale, Gary C.; Sadek, S. A.; Cuschleri, Alfred

doi:10.1016/s0002-9610(88)80123-5

Cited by 12 publications

(5 citation statements)

References 11 publications

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“…3). For studies with a breakdown into upright/supine/total percentage time at pH >7, our results at 12.66/3.44/8.86 were similar to those of Cheadle et al [9] (13.2/2.3/8.16) and Singh et al [5] (10.7/0.0/6.7) (Fig. 4).…”

Section: Discussionsupporting

confidence: 90%

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Twenty-four-hour oesophageal pH studies in rural Eastern Cape Province, South Africa

Ndebia

Sammon

2018

S Afr Med J

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The Eastern Cape Province of South Africa (SA) has a very high incidence of squamous cell cancer of the oesophagus. Recent studies of oesophageal pH/impedance in the Eastern Cape have shown significant differences from other world series: episodes of total reflux and of non-acid reflux are increased, intragastric pH is elevated, and there is evidence supportive of duodenogastric reflux. [1,2] Objectives To investigate 24-hour oesophageal pH in individuals from this highrisk area. Methods Ethical clearance was obtained from the Research Committee of Walter Sisulu University (ref. no. 00011A-04). Healthy adult volunteers aged 18-65 years were recruited from the villages around Canzibe Hospital, near the town of Mthatha in the rural Eastern Cape. Participants were chosen using a self-exclusion questionnaire and not on the basis of diet, education or income. Volunteers with upper gastrointestinal (GI) symptoms were not admitted to the study. No GI endoscopic information was available. All the volunteers gave informed consent. We used a pressure transducer to identify the upper and lower oesophageal sphincters. After calibration we inserted a pH/MMI catheter (K6011-E1-0782; Unisensor, Switzerland) transnasally, positioning the lower pH electrode 10 cm below the lower oesophageal sphincter (LOS) and the upper pH electrode 5 cm above the LOS. Participants went home with the catheter secured in place with tape and attached to an ambulatory pH/impedance recorder (Ohmega; MMS, Netherlands). They were requested to continue their normal activities, and to record episodes of sleep and mealtimes. pH This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.

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Section: Discussionsupporting

confidence: 90%

“…Percentage time at pH >7 (total of upright and supine) in the present study and other published series. Singh et al [5] Cheadle et al [9] Study Fig. 4.…”

Section: Discussionmentioning

confidence: 97%

Twenty-four-hour oesophageal pH studies in rural Eastern Cape Province, South Africa

Ndebia

Sammon

2018

S Afr Med J

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“…The pH threshold was defined as the mean of the calculated Gaussian In the healthy volunteers, the calculated pH thresholds at all oesophageal levels were lower in the supine position than in the upright posture. This supine pH shift, also described in earlier reports [14,27], might be caused by the decreased swallowing rate and the associated impaired oesophageal clearance that occurs during sleep [28,29]. In our opinion, this observation favours the use of separate pH thresholds for the upright and supine periods.…”

Section: Discussionsupporting

confidence: 85%

Objective determination of pH thresholds in the analysis of 24 h ambulatory oesophageal pH monitoring

Weusten¹,

Roelofs

Akkermans

et al. 1996

Eur J Clin Investigation

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In 24 h oesophageal pH monitoring, pH 4 is widely but arbitrarily used as the threshold between reflux and non-reflux pH values. The aim of the study was to define pH thresholds objectively, based on Gaussian curve fitting of pH frequency distributions. Single-channel 24 h oesophageal pH monitoring was performed in 26 healthy volunteers and 26 patients with pathological gastro-oesophageal reflux, and five-channel pH-metry was performed in 14 healthy volunteers and 14 patients. The calculated pH thresholds varied between healthy volunteers from 5 center dot 0 to 6 center dot 4 in the upright position and from 4 center dot 5 to 5 center dot 7 in the supine position, but were constant between different oesophageal recording sites. In 15 and nine patients (single-channel and five-channel pH-metry respectively), pH thresholds could not be determined at the distal oesophageal sites. However, the calculated pH thresholds in the proximal oesophagus were in the same range as in the control subjects. The authors conclude that the use of the conventional threshold of pH 4 leads to underestimation of the extent of gastrooesophageal reflux, but are reluctant to advocate the use of higher thresholds in clinical practice.

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“…Large numbers of reflux events per hour indicate that the lower oesophageal sphincter is acting as a poor barrier to reflux, but prolonged episodes reflect poor clearance. So‐called ‘normal’ ranges have been given by Cheadle and co‐workers 22 . Using their values, five of the patients in the current study can be classified as having ‘normal’ amounts of acid reflux, three as having ‘normal’ numbers of reflux events per hour, and in 10 patients the duration of each event was ‘normal’.…”

Section: Discussionmentioning

confidence: 94%

Patterns of food and acid reflux in patients with low‐grade oesophagitis—the role of an anti‐reflux agent

Washington

Steele

Jackson

et al. 1998

Aliment Pharmacol Ther

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Computerized ambulatory esophageal pH monitoring in 50 asymptomatic volunteer subjects

Cited by 12 publications

References 11 publications

Twenty-four-hour oesophageal pH studies in rural Eastern Cape Province, South Africa

Twenty-four-hour oesophageal pH studies in rural Eastern Cape Province, South Africa

Objective determination of pH thresholds in the analysis of 24 h ambulatory oesophageal pH monitoring

Patterns of food and acid reflux in patients with low‐grade oesophagitis—the role of an anti‐reflux agent

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