Computerised method for pattern recognition of intestinal motility: Functional significance of the spread of contractions

Schemann, Michael; Ehrlein, H. J.; H, Sahyoun

doi:10.1007/bf02456751

Cited by 33 publications

(12 citation statements)

References 8 publications

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“…The analysis used in this study has previously been validated for recognition and differentiation of motility patterns. This method has established the functional significance of the length of spread of contractile waves for the transit of digesta [11]. This study emphasizes that this method is also advantageous in studying different motor profiles under various influences.…”

Section: Discussionmentioning

confidence: 87%

“…To determine the temporal and spatial relation ships o f intestinal contractions a computerized method was used [11]. The computer program counted contractions according to their length of spread.…”

Section: Methodsmentioning

confidence: 99%

“…With conventional methods it is difficult to characterize the motor pattern of the small intestine in vivo [10]. Recently, we have developed a new method for the pattern recognition of intestinal motility determining the propagative nature of contractions [11].…”

Section: Introductionmentioning

confidence: 99%

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5-Hydroxytryptophan and Cisapride Stimulate Propulsive Jejunal Motility and Transit of Chyme in Dogs

Schemann¹,

Ehrlein²

1986

Digestion

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We investigated in conscious dogs the effects of intravenously administered 5-hydroxytryptophan (5-HTP) and cisapride on the postprandial jejunal mechanical activity by means of six closely spaced extraluminal strain gauge transducers. Drugs were given after administration of a nutrient meal. 5-HTP was given additionally after the administration of a noncaloric cellulose meal. Computer assistance was used to determine the temporal and spatial relationship of contractions and thereby to evaluate the length of spread of contractile waves. Both substances increased the propulsive activity, the contractile force and the motility index and fastened the transit rate of digesta. 5-HTP exhibited the most potent effect when given after administration of the nutrient meal.

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Section: Discussionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

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5-Hydroxytryptophan and Cisapride Stimulate Propulsive Jejunal Motility and Transit of Chyme in Dogs

Schemann¹,

Ehrlein²

1986

Digestion

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“…At an organ level, observation of gut movements together with measurements of muscle activity at closely spaced recording sites have identified motor patterns and their role for transport of luminal content (6,14). At a cellular level, visualization of cytochrome oxidase activity (8) or of markers for synaptic release (7), activity-dependent expression of immediate early genes (see Ref.…”

mentioning

confidence: 99%

III. Imaging and the gastrointestinal tract: mapping the human enteric nervous system

Schemann

Michel

Peters

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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Monitoring membrane potentials by multisite optical recording techniques using voltage-sensitive dyes is ideal for direct analysis of network signaling. We applied this technology to monitor fast and slow excitability changes in the enteric nervous system and in hundreds of neurons simultaneously at cellular and subcellular resolution. This imaging technique presents a powerful tool to study activity patterns in enteric pathways and to assess differential activation of nerves in the gut to a number of stimuli that modulate neuronal activity directly or through synaptic mechanisms. The optical mapping made it possible to record from tissues such as human enteric nerves, which were, until now, inaccessible by other techniques.

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“…Similarly, because long periods of recordings were often required to monitor fasting and post-prandial activities, many attempts were made to automate the identification of significant features in those signals. Such developments include analysis of contractile signals [3,9,19], analysis of electrical signals [7,17,21] or both [8,15,18]. As usual, these attempts were initiated but also limited by the available technologies such as amplifiers, digitizers and processing units.…”

Section: Introductionmentioning

confidence: 99%

Mapping slow waves and spikes in chronically instrumented conscious dogs: automated on-line electrogram analysis

et al. 2008

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Myoelectric recordings from the gastrointestinal (GI) tract in conscious animals have been limited in duration and site. Recently, we have implanted 24 electrodes and obtained electrograms from these sites simultaneously (200 Hz sampling rate; 1.1 MB/min data stream). An automated electrogram analysis was developed to process this large amount of data. Myoelectrical recordings from the GI tract often consist of slow wave deflections followed by one or more action potentials (=spike deflections) in the same traces. To analyze these signals, a first module separates the signal into one containing only slow waves and a second one containing only spikes. The timings of these waveforms were then detected, in real time, for all 24 electrograms, in a separate slow wave detection module and a separate spike-detection module. Basic statistics such as timing and amplitudes and the number of spikes per slow wave were performed and displayed on-line. In summary, with this online analysis, it is possible to study for long periods of time and under various experimental conditions major components of gastrointestinal motility.

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Computerised method for pattern recognition of intestinal motility: Functional significance of the spread of contractions

Cited by 33 publications

References 8 publications

5-Hydroxytryptophan and Cisapride Stimulate Propulsive Jejunal Motility and Transit of Chyme in Dogs

5-Hydroxytryptophan and Cisapride Stimulate Propulsive Jejunal Motility and Transit of Chyme in Dogs

III. Imaging and the gastrointestinal tract: mapping the human enteric nervous system

Mapping slow waves and spikes in chronically instrumented conscious dogs: automated on-line electrogram analysis

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