The Suomi-NPP VIIRS Day-Night Band (DNB) offers quantitative measurements of visible and near-infrared light over a dynamic range from full daylight to the dimmest nighttime scenes. This range presents a challenge to radiometric calibration, but the instrument has exceeded all of its absolute radiometric requirements. Nevertheless, striping and banding are still visible, day or night, but especially in low-light scenes. The causes may be cross talk, stray light or hysteresis in the data used for calibration. These issues combine to reduce the utility of these unique observations for gaining new insight on the nocturnal environment. This paper presents methods for improving gain and offset uniformity for both day and night scenes while maintaining absolute radiometric accuracy. We evaluate removal of fixed-pattern non-uniformity in dark scenes on a per orbit basis using three different techniques: i) tracking the darkest 25 th percentile calibration sector signal; ii) taking the mean of filtered dark Earth-view scenes to determine offset; iii) minimizing correlated error for dark scenes within an aggregation zone. For gain uniformity we discuss some problems with the current calibration methods, and demonstrate a technique to minimize the correlated error between detectors and aggregation zones using the moment matching technique for moonlit scenes. A similar technique can be used for daytime and twilight scenes. An alternative cross-calibration technique between gain stages uses indirect illumination of solar diffuser view. The use of the space view and blackbody view for cross-calibration is also discussed. Histogram equalization is discussed for minimizing striping and banding. In all cases, data with stray light is filtered out to prevent contamination of the destriping process.