Computer Modeling for Microwave Ablation in Breast Cancer Using a Coaxial Slot Antenna

Rubio, Mario Francisco Jesús Cepeda; Guerrero, Geshel David; Perezgasga, Francisco Valdés; García, Francisco Flores; Vera, A.; Salas, Lorenzo Leija

doi:10.1007/s10765-015-1931-2

Cited by 14 publications

(8 citation statements)

References 34 publications

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“…The ablative treatment family includes microwave ablation (MWA), radiofrequency ablation (RFA), ethanol ablation, laser ablation, and cryoablation [12][13][14][15][16][17]. Recently, a wide number of experimental and theoretical works have been focused on improving MWA [18][19][20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, they revealed that a coaxial antenna with multi-slots generates the smallest over-treatment region for spherical tumors. Rubio et al (2015) performed a computer simulation in order to compare heating differences between cancer and normal breast tissue [26]. They demonstrated that the dielectric and thermal parameters relative to cancer and normal breast tissue are able to create special heating of tumors during microwave ablation.…”

Section: Introductionmentioning

confidence: 99%

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Numerical Analysis of Human Cancer Therapy Using Microwave Ablation

2019

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Microwave ablation is one type of hyperthermia treatment of cancer that involves heating tumor cells. This technique uses electromagnetic wave effects to kill cancer cells. A micro-coaxial antenna is introduced into the biological tissue. The radiation emitted by the antenna is absorbed by the tissue and leads to the heating of cancer cells. The diffuse increase in temperature should reach a certain value to achieve the treatment of cancer cells but it should be less than a certain other value to avoid damaging normal cells. This is why hyperthermia treatment should be carefully monitored. A numerical simulation is useful and may provide valuable information. The bio-heat equation and Maxwell’s equations are solved using the finite element method. Electro-thermal effects, temperature distribution profile, specific absorption rate (SAR), and fraction of necrotic tissue within cancer cells are analyzed. The results show that SAR and temperature distribution are strongly affected by input microwave power. High microwave power causes a high SAR value and raises the temperature above 50 °C, which may destroy healthy cells. It is revealed that with a power of 10 W, the tumor cells will be killed without damaging the surrounding tissue.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Numerical Analysis of Human Cancer Therapy Using Microwave Ablation

2019

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“…Karampatzakis et al [20] conducted a parametric study on the design parameters of microwave antenna and studied the impact of using triangular and rectangular array antennas on their heating characteristics. Rubio et al [21] showed the difference in heating patterns of a normal and a cancerous breast using computational studies. The effect of biological properties of cancerous breast, viz., composition, tumor characteristics (size and location) are still not explored significantly so far in MWA.…”

Section: Introductionmentioning

confidence: 99%

Numerical Investigation on the Effect of Different Physiological Cancerous Breast Parameters on the Output of Microwave Ablation

Kumar

Repaka

2020

Journal of Engineering and Science in Medical Diagnostics and Therapy

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Microwave ablation (MWA) is a newly developed minimally invasive tumor therapy which possesses several advantages over the existing thermal therapies. Despite the several advantages, MWA also suffers same disadvantages similar to other thermal therapies like poor control over ablation volume. Sensitivity of different tissue parameters is the key factor to design a MWA protocol. In this work, sensitivity analysis has been conducted to quantify the effect of three cancerous breast parameters, viz., breast composition, tumor location, and tumor size, on the efficacy of MWA of breast cancer. Ablation volume has been taken as the indicator of the ablation efficacy during MWA procedure. A Taguchi's design of experimental approach has been utilized to optimize the number of simulations required for the analysis and then analysis of variance (ANOVA) has been performed to predict the most sensitive parameter along with their individual contribution. Finite element approach-based simulations have been performed in a multiphysics software. First, a grid-independent study has been established to optimize the number of mesh elements and to reduce the computational cost. Then, after finding the most optimum grid size, all the simulations have been performed in accordance with the protocol obtained from Taguchi's design of experiment approach and finally statistical analysis software has been used for analyzing Taguchi's design. It has been found that, the breast composition to be the most significant factor, with maximum contribution in ablation volume, among three considered factors followed by tumor location and tumor size, respectively.

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“…The objective of this work is to evaluate the efficiency of two applicators with the same design, slot antenna (Cepeda et al, 2015), but different diameters, to determine the feasibility of using a thinner applicator, which facilitates puncture, since it is important to select the most suitable type of cable for microwave ablation.…”

Section: Introductionmentioning

confidence: 99%

In-Silico study of microwave ablation applicators of different size for breast cancer treatment

Hernández-Jácquez¹,

Rubio²,

Guerrero³

et al. 2020

iit

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Breast cancer is one of the most common types of cancer in females around the world, surgery is the preferred treatment for this disease in early stages, however there are some emergent treatment options with less clinical and cosmetically repercussions, being one of these the microwave ablation. Microwave ablation is a minimally invasive technique used to treat tumors in different organs of the human body, mainly in liver, lung and kidney. It consist on the destruction of the tumor by rising the temperature of the cells until necrosis is achieve. In breast tumors, this technique has been rarely used in human patients. Depending on the type of tissue, an applicator must be made to be coupled to ensure that energy used is not reflected, so the standing wave ratio is closest to 1. In order to determine an appropriate design for the applicators that could be used for the treatment of breast cancer, an in-silico study of microwave ablation of breast cancer was made to show the difference between micro-coaxial applicators constructed with two different types of coaxial cable (UT-47 and UT-85) utilizing the same design in three possible scenarios breast tissue, tumor tissue and tumor surrounded by breast tissue. The simulation was realized using COMSOL Multiphysics commercial software, due to its capabilities to simulate the electromagnetics and thermals effects. A slot type applicator was selected because of its ease of manufacture and the available literature on it. The results shows a better coupling for the applicator constructed with the UT-47 cable, especially in the tumor phantom surrounded by breast phantom test.

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Computer Modeling for Microwave Ablation in Breast Cancer Using a Coaxial Slot Antenna

Cited by 14 publications

References 34 publications

Numerical Analysis of Human Cancer Therapy Using Microwave Ablation

Numerical Analysis of Human Cancer Therapy Using Microwave Ablation

Numerical Investigation on the Effect of Different Physiological Cancerous Breast Parameters on the Output of Microwave Ablation

In-Silico study of microwave ablation applicators of different size for breast cancer treatment

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