“…Despite continuing interest in SV cell types, an understanding of cellular heterogeneity, including a comprehensive understanding of SV cell type-specific transcriptional profiles, is incomplete. While several in vivo, in vitro, and in silico studies have identified key roles for particular strial cell types in EP generation, including MCs, ICs, and BCs (Takeuchi et al, 2000;Nin et al, 2008;Mori et al, 2009;Hibino et al, 2010;Chen and Zhao, 2014;Yoshida et al, 2015;Nin et al, 2017), the mechanisms by which the various cell types work together to accomplish EP generation as well as other strial functions remains largely undefined (Ohlemiller, 2009). Furthermore, the gene regulatory networks that provide the basis for these EP-generating mechanisms remain largely undefined.…”