“…In all, 11 amino‐acid residues in p47 UBA and 12 in ubiquitin were identified to have weighted chemical shift changes significantly greater than the average; 0.07 ppm in ubiquitin and 0.09 ppm in p47 UBA were chosen as suitable cutoff values. After filtering for a relative solvent accessibility greater than 50%, as calculated using the program Naccess (Hubbard and Thornton, 1993), eight residues in p47 UBA (Q6, V15, G17, Q35, A39, S40, Y42 and D44) and eight for ubiquitin (K6, K11, A46, K48, Q49, H68, R72 and R74) were identified as active residues. Residues juxtaposed to these, which have a relative solvent accessibility greater than 50%, were termed passive residues.…”