Computer-controlled Infusion of Intravenous Dexmedetomidine Hydrochloride in Adult Human Volunteers

The Effect of Obesity on Dose of Dexmedetomidine When Administered With Fentanyl During Postoperative Mechanical Ventilation - Retrospective

“…Dyck et al built a pharmacokinetic model of DEX which included height as a covariate for central clearance in non -obese (mean body weight of 82 kg) adult volunteers 10) . Valitalo et al 11) performed a population pharmacokinetic analysis of DEX in critically ill patients in the intensive care unit (ICU) and found that TBW strongly correlates to clearance, and their final model included a TBW covariate on clearance.…”

Effect of dexmedetomidine, midazolam, and propofol on lipopolysaccharide‑stimulated dendritic cells

“…These dosages included clinical dosages (0.001-1 µM dexmedetomidine, 0.1-10 µM midazolam, and 1-50 µM propofol) as well as a supra-concentration of every drug (0.5 µM dexmedetomidine, 50 µM midazolam, and 100 µM propofol) (18,(20)(21)(22). The concentration of LPS for all treatments was 1 µg/ml.…”

Cardiovascular reactivity to mental stress is not affected by alpha2-adrenoreceptor activation or inhibition

“…Dexmedetomidine has the advantage of a short half-life, which makes it especially suitable for intravenous administration. Indeed, computercontrolled (STANPUMP) infusion pump setups have been developed (Dyck et al 1993), and several studies have shown that these devices validly control dexmedetomidine plasma concentrations during different circumstances in humans (Talke et al 2003). Some studies indicated excellent concentration-response associations of dexmedetomidine with plasma catecholamines (Scheinin et al 1998) and psychomotor reaction time (Angst et al 2004).…”