Computer-based model of epidural motor cortex stimulation: Effects of electrode position and geometry on activation of cortical neurons

Wongsarnpigoon, Amorn; Grill, Warren M.

doi:10.1016/j.clinph.2011.06.005

Cited by 64 publications

(98 citation statements)

References 73 publications

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“…In principle, the process involves exploring various montages (dose) with the goal of identifying a current flow pattern that best supports the presumed mechanism of action or experimental hypothesis (Wongsarnpigoon and Grill, 2012). However, how to select a "best" target and consider collateral brain current flow (side effects) is an open question (Cheung et al, 2014;Fytagoridis et al, 2013) because the relationship between brain current flow patterns and cognition is complex.…”

Section: Step 1: Forward Models Of Current Flowmentioning

confidence: 99%

Modeling sequence and quasi-uniform assumption in computational neurostimulation

Bikson¹,

Truong²,

Mourdoukoutas³

et al. 2015

Progress in Brain Research

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Section: Step 1: Forward Models Of Current Flowmentioning

confidence: 99%

Modeling sequence and quasi-uniform assumption in computational neurostimulation

Bikson¹,

Truong²,

Mourdoukoutas³

et al. 2015

Progress in Brain Research

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“…Restricting study to a specific area of the brain, and considering anatomical shape to some extent, extruded slab models that represent the motor cortex have also been generated to investigate the effects of motor cortex stimulation [18][19][20]. These modelling studies may elucidate the neuromodulation effects in more focused target areas; however, the prediction of overall current density in the whole brain may be misinterpreted due to non-negligibly significant mismatches between these models.…”

Section: Introductionmentioning

confidence: 98%

Validation of Computational Studies for Electrical Brain Stimulation With Phantom Head Experiments

Kim

Jeong

et al. 2015

Brain Stimulation

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“…Computational studies of ECS have been conducted with a simplified extruded slab model of the precentral gyrus [23]–[26]. Using these models, they have revealed how electric current generated by brain stimulation is distributed in the brain.…”

Section: Introductionmentioning

confidence: 99%

“…Using these models, they have revealed how electric current generated by brain stimulation is distributed in the brain. Furthermore, neuronal response has been predicted using computational models of epidural motor cortex stimulation [23], [24], [26]. Recently, our group developed a computational extruded slab model for SuCS [30], [31] and analyzed the variation in the amount of current flow in the brain when stimulation amplitude, electrode shape, and electrode position were altered.…”

Section: Introductionmentioning

confidence: 99%

Computational Study on Subdural Cortical Stimulation - The Influence of the Head Geometry, Anisotropic Conductivity, and Electrode Configuration

et al. 2014

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Subdural cortical stimulation (SuCS) is a method used to inject electrical current through electrodes beneath the dura mater, and is known to be useful in treating brain disorders. However, precisely how SuCS must be applied to yield the most effective results has rarely been investigated. For this purpose, we developed a three-dimensional computational model that represents an anatomically realistic brain model including an upper chest. With this computational model, we investigated the influence of stimulation amplitudes, electrode configurations (single or paddle-array), and white matter conductivities (isotropy or anisotropy). Further, the effects of stimulation were compared with two other computational models, including an anatomically realistic brain-only model and the simplified extruded slab model representing the precentral gyrus area. The results of voltage stimulation suggested that there was a synergistic effect with the paddle-array due to the use of multiple electrodes; however, a single electrode was more efficient with current stimulation. The conventional model (simplified extruded slab) far overestimated the effects of stimulation with both voltage and current by comparison to our proposed realistic upper body model. However, the realistic upper body and full brain-only models demonstrated similar stimulation effects. In our investigation of the influence of anisotropic conductivity, model with a fixed ratio (1∶10) anisotropic conductivity yielded deeper penetration depths and larger extents of stimulation than others. However, isotropic and anisotropic models with fixed ratios (1∶2, 1∶5) yielded similar stimulation effects. Lastly, whether the reference electrode was located on the right or left chest had no substantial effects on stimulation.

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Computer-based model of epidural motor cortex stimulation: Effects of electrode position and geometry on activation of cortical neurons

Cited by 64 publications

References 73 publications

Modeling sequence and quasi-uniform assumption in computational neurostimulation

Modeling sequence and quasi-uniform assumption in computational neurostimulation

Validation of Computational Studies for Electrical Brain Stimulation With Phantom Head Experiments

Computational Study on Subdural Cortical Stimulation - The Influence of the Head Geometry, Anisotropic Conductivity, and Electrode Configuration

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