2013
DOI: 10.4997/jrcpe.2013.215
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Computer-based diagnosis of illness in historical persons

Abstract: Retrospective diagnosis of illness in historical figures is a popular but somewhat unreliable pastime due to the lack of detailed information and reliable reports about clinical features and disease progression. Modern computer-based diagnostic programmes have been used to supplement historical documents and accounts, offering new and more objective approaches to the retrospective investigations of the medical conditions of historical persons. In the case of King George III, modern technology has been used to … Show more

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Cited by 5 publications
(3 citation statements)
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“…England suffered undisputed periods of insanity requiring regencies 16,31,32. Some authorities believe King George III suffered from porphyria31 and suggest that his ancestors Margaret Tudor (the sister of Henry VIII), Mary Queen of Scots and King James VI of Scotland also suffered from this condition.…”
mentioning
confidence: 99%
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“…England suffered undisputed periods of insanity requiring regencies 16,31,32. Some authorities believe King George III suffered from porphyria31 and suggest that his ancestors Margaret Tudor (the sister of Henry VIII), Mary Queen of Scots and King James VI of Scotland also suffered from this condition.…”
mentioning
confidence: 99%
“…Some authorities believe King George III suffered from porphyria31 and suggest that his ancestors Margaret Tudor (the sister of Henry VIII), Mary Queen of Scots and King James VI of Scotland also suffered from this condition. Yet this diagnosis is highly disputed;[32][33][34] other postulated alternative diagnoses including arsenic toxicity and depression have been suggested for George III,31,32,34 and bipolar disorder or schizophrenia for Charles VI and Henry VI 35. Since Catherine de Valois (daughter of Charles VI of France), links all three as wife of Henry V, and subsequently, mother of Henry VI, grandmother of Henry VII, great grandmother of Henry VIII, and a direct ancestor of George III, it is tempting to speculate that she carried and shared a partially penetrant genetic predisposition to mental illness.…”
mentioning
confidence: 99%
“…12 In contrast, the only mental disorder sometimes associated with acute porphyria, even in complete remission, is anxiety. 13 In order to provide an objective diagnosis of the king's mental disorder, current techniques of cognitive archaeology 14 including computer diagnostics 15 and handwriting analysis 16 are currently being applied to the primary source data.…”
Section: Introductionmentioning
confidence: 99%