Computer-assisted cognitive remediation therapy in schizophrenia: Durability of the effects and cost-utility analysis

Garrido, Gemma; Penadés, Rafael; Barrios, Maite; Aragay, Núria; Ramos, I. Veiga; Vallès, Vicenç; Faixa, Carlota; Vendrell, Josep M.

doi:10.1016/j.psychres.2017.04.065

Cited by 51 publications

(29 citation statements)

References 57 publications

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“…Melby-Lervag & Hulme, 2013). Our work showing significant benefits on school-administered math and reading achievement tests (Wexler et al, 2016) and previous work by us and others showing transfer to employment gains in adult clinical populations (Belleville et al, 2017;Buonocore et al, 2018;Fiszdon, Bryson, Wexler, & Bell, 2004;Garrido et al, 2017), among other studies, speak to the issue of generalization of benefit. We are not aware, however, of data related to the durability of training effects in healthy children.…”

Section: Introductionsupporting

confidence: 70%

Increasing Readiness to Learn: Benefits of Executive Function Training in Kindergarten Carry over to First Grade

Imal¹,

Wexler²

2018

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Executive Function skills such as focused attention, inhibition or self-control, and working memory in preschool and kindergarten predict reading and math achievement in elementary school and beyond. A growing body of research indicates that these skills can be improved by repetitive practice of progressively more difficult tasks that require Executive Function. We report that children who participated in an integrated program of computer presented and physical exercises to improve Executive Function when in kindergarten then entered first grade with greater attention and self-control skills than their first grade classmates who had not participated in the program.

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Section: Introductionsupporting

confidence: 70%

Increasing Readiness to Learn: Benefits of Executive Function Training in Kindergarten Carry over to First Grade

Imal¹,

Wexler²

2018

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“…As the field continues to grow, with several treatment programs available, health care decision makers who wish to bring cognitive remediation to the clinic should be encouraged that, although this treatment requires training and staff time, the cost‐benefit analysis is favorable. Studies of cognitive remediation have systematically reported on how this trade‐off affects quality of life and financial burden associated with cognitive impairment, with evidence supporting higher rates of employment, reduced job stress, and lower institutional treatment demands.…”

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confidence: 99%

Cognitive remediation for severe mental illness: state of the field and future directions

Bowie

2019

World Psychiatry

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“…The fact that from about the seventh day Wisket rats consumed the same amount of rewards as controls may reflect that the learning impairment was greatly overcome by the repetition of the tasks. Since cognitive training also improves cognitive performance in schizophrenic patients, and it can decrease the chance of acute psychiatric admission, too [13][14][15][16][17][18]30], we suggest the predictive validity of this model in this respect. Several brain structures (e.g.…”

Section: (Continued On Next Page)mentioning

confidence: 85%

“…Unfortunately, the antipsychotic drugs are ineffective in the treatment of negative symptoms and cognitive impairments. Recent data suggest that patients with schizophrenia may regain memory function close to normal after intensive cognitive training for a prolonged period [14][15][16][17][18]. It is well-known that the cognitive functions significantly depend on the behavioral activity, which is impaired in schizophrenic patients, too [19][20][21], and a close relationship was detected between reinforcement learning and general psychosocial functioning in schizophrenia [22].…”

Section: Introductionmentioning

confidence: 99%

Cognitive training improves the disturbed behavioral architecture of schizophrenia-like rats, “Wisket”

Horváth

Liszli

Kekesi

et al. 2019

Physiology & Behavior

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Translational schizophrenia research depends on the relevance of animal models supported by reliable tests. Human data suggest that the intensive cognitive training in schizophrenia improves the memory impairments and decreases the chance of acute psychiatric remission. Here we examined the effects of a 10-day long training session in the behavioral architecture of a new schizophrenia-like rat substrain (Wisket) in a narrow square corridor with food rewards (AMBITUS). The instrument was designed to model the natural environment of rats and enable the simultaneous recording of multiple behavioral parameters. For the compact visualization of differences between the Wisket and control animals in several parameters (behavioromics), color-coded grid plots were applied. The Wisket animals exhibited an altered pattern and/or amount of locomotion, exploratory and food collecting activity at the first few days, revealing impaired motivation, attention, anxiety and learning ability (face validity). Most of the parameters normalized with training, except for the decreased exploratory activity. This resembles the effects of cognitive behavioral therapy in human schizophrenics providing a significant support for the predictive validity of this substrain as an animal model of schizophrenia. This study also highlights the importance of behavior tests that investigate the egocentric learning ability during reward-based tasks.

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Computer-assisted cognitive remediation therapy in schizophrenia: Durability of the effects and cost-utility analysis

Cited by 51 publications

References 57 publications

Increasing Readiness to Learn: Benefits of Executive Function Training in Kindergarten Carry over to First Grade

Increasing Readiness to Learn: Benefits of Executive Function Training in Kindergarten Carry over to First Grade

Cognitive remediation for severe mental illness: state of the field and future directions

Cognitive training improves the disturbed behavioral architecture of schizophrenia-like rats, “Wisket”

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