In the 1970s, to control costs and comply with Medicare rules, hospitals began to use computer-based systems for utilization review. In the early 1980s, a diagnostic related group (DRG) approach was applied to hospital payments, and increasingly complex data reporting requirements led hospitals to establish quality assurance programs. Medical information, or medical knowledge, databases for clinical decision support (CDS) were developed in the 1980s. The capabilities provided by online real time monitoring, vastly increased data storage, and physician order entry and results reporting (OE/RR) came together in CDS programs in the 2000s; by 2010 most physicians were using systems that provided online practice guidelines as well as clinical reminders and alerts about potential adverse clinical events. These advances build upon techniques from other fi elds, including artifi cial intelligence; the emergence of huge clinical databases in the 1990s led to the use of data mining to uncover previously unknown important relationships between clinical data elements, and the use of effi cient knowledge discovery algorithms to extract knowledge from data by identifying and describing patterns in a meaningful manner. To support knowledge creation in biomedicine, the National Library of Medicine produces and maintains hundreds of up-to-date scientifi c databases, including MEDLINE (over 23 million citations with 700,000 posted in 2013 alone), human genome resources, toxicology and environmental databases (searched billions of times a year by millions around the globe).