Computer Algorithms in the Search for Unrelated Stem Cell Donors

Steiner, David

doi:10.1155/2012/175419

Cited by 9 publications

(8 citation statements)

References 5 publications

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“…Therefore, the rapid and reliable identification of suitable adult volunteer HSC donor candidates and/or cord blood units for individual patients is of primary importance. This challenging search process is routinely performed in a donor registry or cord blood bank by a computer program in which the HLA‐matching algorithm (HMA) can be regarded as the core element . For simplicity, we will use the term ‘donor’ to refer to donors of HSCs from bone marrow or peripheral blood and cord blood units and the term ‘donor registry’ shall include cord blood banks.…”

Section: Introductionmentioning

confidence: 99%

A comparative reference study for the validation of HLA‐matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units

Bochtler

Gragert

Patel

et al. 2016

HLA

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The accuracy of human leukocyte antigen (HLA)‐matching algorithms is a prerequisite for the correct and efficient identification of optimal unrelated donors for patients requiring hematopoietic stem cell transplantation. The goal of this World Marrow Donor Association study was to validate established matching algorithms from different international donor registries by challenging them with simulated input data and subsequently comparing the output. This experiment addressed three specific aspects of HLA matching using different data sets for tasks of increasing complexity. The first two tasks targeted the traditional matching approach identifying discrepancies between patient and donor HLA genotypes by counting antigen and allele differences. Contemporary matching procedures predicting the probability for HLA identity using haplotype frequencies were addressed by the third task. In each task, the identified disparities between the results of the participating computer programs were analyzed, classified and quantified. This study led to a deep understanding of the algorithms participating and finally produced virtually identical results. The unresolved discrepancies total to less than 1%, 4% and 2% for the three tasks and are mostly because of individual decisions in the design of the programs. Based on these findings, reference results for the three input data sets were compiled that can be used to validate future matching algorithms and thus improve the quality of the global donor search process.

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Section: Introductionmentioning

confidence: 99%

A comparative reference study for the validation of HLA‐matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units

Bochtler

Gragert

Patel

et al. 2016

HLA

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“…Typically, a prospective BMT recipient's siblings are screened for suitability of donors and failing this, the search is widened to unrelated persons. Nevertheless, at the time of this writing, a large percentage of patients requiring allogeneic HSC are unable to identify matching donors .…”

Section: Cellular and Molecular Features Of Senescencementioning

confidence: 99%

Management of multicellular senescence and oxidative stress

Haines

Juhász

Tósaki

2013

J Cellular Molecular Medi

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Progressively sophisticated understanding of cellular and molecular processes that contribute to age-related physical deterioration is being gained from ongoing research into cancer, chronic inflammatory syndromes and other serious disorders that increase with age. Particularly valuable insight has resulted from characterization of how senescent cells affect the tissues in which they form in ways that decrease an organism's overall viability. Increasingly, the underlying pathophysiology of ageing is recognized as a consequence of oxidative damage. This leads to hyperactivity of cell growth pathways, prominently including mTOR (mammalian target of rapamycin), that contribute to a build-up in cells of toxic aggregates such as progerin (a mutant nuclear cytoskeletal protein), lipofuscin and other cellular debris, triggering formation of senescent cellular phenotypes, which interact destructively with surrounding tissue. Indeed, senescent cell ablation dramatically inhibits physical deterioration in progeroid (age-accelerated) mice. This review explores ways in which oxidative stress creates ageing-associated cellular damage and triggers induction of the cell death/survival programs’ apoptosis, necrosis, autophagy and ‘necroapoptophagy’. The concept of ‘necroapoptophagy’ is presented here as a strategy for varying tissue oxidative stress intensity in ways that induce differential activation of death versus survival programs, resulting in enhanced and sustained representation of healthy functional cells. These strategies are discussed in the context of specialized mesenchymal stromal cells with the potential to synergize with telocytes in stabilizing engrafted progenitor cells, thereby extending periods of healthy life. Information and concepts are summarized in a hypothetical approach to suppressing whole-organism senescence, with methods drawn from emerging understandings of ageing, gained from Cnidarians (jellyfish, corals and anemones) that undergo a unique form of cellular regeneration, potentially conferring open-ended lifespans.

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“…Esta busca por um doador compatível é realizada através de um algoritmo de compatibilidade HLA (HLA matching algorithm -HMA) [Bochtler et al 2016], cujo objetivo é buscar em um cadastro de voluntários os potenciais doadores [Steiner 2012]. A compatibilidade entre paciente-doador é definida pelo número de alelos compartilhados pelos genes HLA-A, -B, -C, -DRB1 e -DQB1 [Geffard et al 2019].…”

Section: Introduc ¸ãOunclassified

Uma Abordagem para Análise de Padrões em Banco de Dados de Doadores de Órgãos

Silva

Figueiredo

Porto

et al. 2022

Anais Do XXII Simpósio Brasileiro De Computação Aplicada À Saúde (SBCAS 2022)

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A procura por um doador compatível é realizada através de um algoritmo de busca, cujo objetivo é buscar em um cadastro de voluntários os potenciais doadores. Nesse contexto, a partir da implementação de um algoritmo de busca por doadores compatíveis, o objetivo deste artigo é propor e implementar uma ferramenta para analisar padrões em banco de dados de doadores de órgãos, que ajude a médicos e pesquisadores obterem informações para aprimorar o processo de doação de órgãos entre doadores não relacionados. Resultados iniciais mostraram que a ferramenta é capaz de realizar as análises propostas, assim como reduzir significativamente o tempo necessário de acordo com a arquitetura computacional disponível.

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Computer Algorithms in the Search for Unrelated Stem Cell Donors

Cited by 9 publications

References 5 publications

A comparative reference study for the validation of HLA‐matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units

A comparative reference study for the validation of HLA‐matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units

Management of multicellular senescence and oxidative stress

Uma Abordagem para Análise de Padrões em Banco de Dados de Doadores de Órgãos

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