2021
DOI: 10.1007/s42452-021-04748-5
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Computer-aided molecular design of 2-anilino 4-amino substituted quinazolines derivatives as malarial inhibitors

Abstract: Quantitative structure–activity relationship studies conducted on forty-five (45) derivatives of 2-anilino 4-amino substituted quinazolines as malaria inhibitors to determine the structures responsible for their antimalarial properties and design novel derivatives with improved activities. The molecular descriptors generated were selected to develop the theoretical model using the genetic approximation component of the material studio. The developed model found to be a function of ATSC8c, GATS8i, SpMin1_Bhi, J… Show more

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