Computer-Aided Identification of Kinase-Targeted Small Molecules for Cancer: A Review on AKT Protein
Erika Primavera,
Deborah Palazzotti,
Maria Letizia Barreca
et al.
Abstract:AKT (also known as PKB) is a serine/threonine kinase that plays a pivotal regulatory role in the PI3K/AKT/mTOR signaling pathway. Dysregulation of AKT activity, especially its hyperactivation, is closely associated with the development of various human cancers and resistance to chemotherapy. Over the years, a wide array of AKT inhibitors has been discovered through experimental and computational approaches. In this regard, herein we present a comprehensive overview of AKT inhibitors identified using computer-a… Show more
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