Computer-aided (HistoScanning) Biopsies Versus Conventional Transrectal Ultrasound-guided Prostate Biopsies: Do Targeted Biopsy Schemes Improve the Cancer Detection Rate?

Approaches for Initial Prostate Biopsy and Antibiotic Prophylaxis

“…A prospective RCT revealed a 12% improvement in detection rate for a 10-core scheme including elastography-targeted cores when compared with a 10-core systematic scheme in line with series using each patient as his own control [42,43]. No clear benefit has been demonstrated for histoscanning and contrast-enhanced US, and future welldesigned studies are awaited [44].…”

Editorial Comment from Dr Salomon to Prostate HistoScanning: A screening tool for prostate cancer?

“…HistoScanning has been introduced to the market with only a few publications showing its potential accuracy in detecting prostate cancer (PCA) foci, and its technique has been questioned . Three out of the five existing original publications with a limited number of patients have shown the potential visualization of PCA foci within the prostate in PCA patients before radical prostatectomy.…”

“…The question should be raised as to what benefit HistoScanning adds to our daily urological work. Just two articles deal with the clinical issues of: (i) the value of HistoScanning for targeted biopsies; and (ii) the prediction of a negative margin in prostatectomy patients …”

Editorial Comment from Dr Simmons to Prostate HistoScanning: A screening tool for prostate cancer?

“…In effect, however, they were using this as a triage test . HistoScanning has shown reasonable performance characteristics for the detection of prostate cancer in previous studies, and has recently been evaluated as a tool to guide biopsy and assist with surgical planning …”

“…In effect, however, they were using this as a triage test. 5 HistoScanning has shown reasonable performance characteristics for the detection of prostate cancer [6][7][8] in previous studies, and has recently been evaluated as a tool to guide biopsy 9 and assist with surgical planning. 10 The authors investigate the use of HistoScanning in association with clinical factors (digital rectal examination, prostate-specific antigen and prostate-specific antigen velocity) to determine whether a man should undergo prostate biopsy.…”