Computer‐Aided Design and Analysis of Spectrally Aligned Hybrid Plasmonic Nanojunctions for SERS Detection of Nucleobases

Abstract

fingerprints in the form of Raman scattering signals are significantly enhanced when target molecules are in close proximity to the surface of plasmonic nanostructures. [1] In particular, SERS detection schemes show promise in point-of-care biosensing and on-site environmental monitoring owing to their key advantages, including high sensitivity, multiplexing capability, minimal sample preparation, water tolerance, and compatibility to portable devices. Nevertheless, their widespread utilization is still hindered by the challenge in developing a facile fabrication scheme for highly precise and reproducible SERS substrates.

Fabrication of nanostructured electrodes for electrochemical surface-enhanced Raman spectroscopy (E-SERS): A review

“…The magnitude of the EM field depends on the size and shape of the NP [26]. Very large enhancements, known as 'hot spots', can be formed between two NPs or in carefully designed nanostructures [24,[28][29][30]. Single particles do not exhibit particularly significant EFs ( ∼ 10 3 ) but very large EFs ( ∼ 10 5 to 10 8 ) are found at the junctions between two particles (Figure 2a).…”

“…For example, coating a plasmonic metal in a dielectric material can improve the stability of the NPs [125,126] and coating an inexpensive carrier with a noble metal can reduce the cost of plasmonic NPs [127]. Additionally, certain hybrid particles, such as gold core-silver shell NPs and plasmonic metal-semiconductor NPs, can exhibit charge transfer between the two materials which can lead to boosted SERS enhancements [30,67,[128][129][130][131][132][133][134][135][136].…”

Plasmonic Nano‐Rotamers with Programmable Polarization‐Resolved Coloration

“…[1,2] The ability to design plasmonic molecules at the nanoscale holds DOI: 10.1002/adom.202301730 immense potential for polarizationsensitive optical metamaterials that are currently beyond reach. [3][4][5][6][7][8][9] Plasmonic isomers, such as dimers [1] and trimers, [10] arise distinct coupled resonance when illuminated with linearly polarized light along their long axis, offering a wide range of applications in optical devices including, filters, [11,12] sensors, [13,14] and encryption. [15,16] Recent advances in nanofabrication techniques have further facilitated the realization of 3D structural nano-architecture, enabling the exploration of enantiomers, i.e., stereoisomers that are not superimposable with their mirror image.…”

Modulation of redox reactivity of resazurin through host-guest complexation with Cucurbit[n]uril (n = 7, 8)

“…Cucurbitu [n]rils (CBn, n = 5-8) are a family of macrocyclic hosts synthesized through the condensation of affordable starting materials (Barrow et al, 2015;Lin et al, 2020). Their versatile properties offer a wide range of potential applications, including reactivity modulation (Lee et al, 2013;Moorthy et al, 2022;Moorthy et al, 2023), drug delivery (Walker et al, 2011), environmental monitoring (Chio et al, 2022), explosive detection (Chio et al, 2019) and biosensing (Chio et al, 2020;Chio et al, 2021;Davison et al, 2023). Notably, CB7 and CB8, are both water-soluble (with a solubility of >20 mM for CB7 and <0.1 mM for CB8, depending on the preparation method) and highly biocompatible, demonstrate promising applicability in aqueous-based scenarios, such as biological systems (Uhlenheuer et al, 2010) and electrochemical investigations (Boulas et al, 1998;Jeon et al, 2002;Gadde et al, 2009;Luo et al, 2019).…”