Computer-Aided Delivery of High-Intensity Focused Ultrasound (HIFU) for Creation of an Atrial Septal Defect in Vivo

Yamashita, Hiromasa; Ishii, Tetsuko; Ishiyama, Akihiko; Nakayama, Noriyoshi; Miyoshi, T.; Miyamoto, Yoshitaka; Kitazumi, Gontaro; Katsuike, Yasumasa; Okazaki, Makoto; Azuma, Takashi; Fujisaki, Masayuki; Takamoto, Shinichi; Chiba, Tadatoshi

doi:10.1007/978-3-540-79982-5_33

Cited by 4 publications

(2 citation statements)

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“…Herein, we provide observations that can inform the selection of sonication parameters to produce controllable titrate-able and predictable bioeffects in liver, kidney, and cardiac muscle on a clinical MRI HIFU system. While liver and kidney have been widely used as target tissues in HIFU research, cardiac muscle was included, since HIFU has potential cardiac-specific clinical applications in, e.g., treatment of arrhythmias, septal defects and hypertrophic obstructive cardiomyopathy [47, 48, 49, 50]. Sonication parameters that produce a vacuolated lesion may hold potential in precisely debulking tumors while minimizing injury to nearby critical structures (such as nerves) via a sharp, well-demarcated transition zone.…”

Section: Discussionmentioning

confidence: 99%

Mechanical fractionation of tissues using microsecond-long HIFU pulses on a clinical MR-HIFU system

Eranki

Farr

Partanen

et al. 2018

International Journal of Hyperthermia

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Section: Discussionmentioning

confidence: 99%

Mechanical fractionation of tissues using microsecond-long HIFU pulses on a clinical MR-HIFU system

Eranki

Farr

Partanen

et al. 2018

International Journal of Hyperthermia

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“…System configuration of the computer-based automatic HIFU delivery. et al, 2010; Yamashita et al, 2008b). The system consists of HIFU delivery device with monocoque spherical shaped piezo transducer and diagnostic 2D-US imaging probe, 2D-US imaging equipment, workstation, function generator and RF power amplifier to drive the transducer (Fig.…”

Section: Automatic Hifu Delivery Systemmentioning

confidence: 99%

Super Eyes and Hands for Future Fetal Intervention

Yamashita¹,

Kakimoto²,

Yuan³

et al. 2012

Perinatal Mortality

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Yamashita

Kitazumi

Ishii

et al. 2009

Journal of Life Support Engineering

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In recent years, several fetal cardiac malformations such as hypoplastic left heart syndrome have been increasingly treated before birth with gradually improved outcome, although the technique is still invasive. We newly developed an automatic delivery system of high-intensity focused ultrasound (HIFU) with real-time 2D-ultrasound imaging analysis to correct cardiac morphologic abnormalities less invasively. The system could be controlled by a computer-based analysis of 2D-ultrasound left ventricular images for optimal HIFU deliveries. Using beating heart of four anesthetized adult rabbits, the system successfully achieved a non-touch gross ablation of the atrial septum in three animals, and in the other HIFU delivery was slightly mistargeted on the posterior wall of the left atrium with a resultant small transmural opening. We believe that the system will be introduced with pinpoint accuracy to minimally invasive fetal cardiac interventions that have intact or highly restrictive atrial septum. Key WordsHypoplastic left heart syndrome, Analysis of 2D-ultrasound left ventricular image, Pinpoint ablation of the atrial septum.

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Computer-Aided Delivery of High-Intensity Focused Ultrasound (HIFU) for Creation of an Atrial Septal Defect in Vivo

Cited by 4 publications

References 12 publications

Mechanical fractionation of tissues using microsecond-long HIFU pulses on a clinical MR-HIFU system

Mechanical fractionation of tissues using microsecond-long HIFU pulses on a clinical MR-HIFU system

Super Eyes and Hands for Future Fetal Intervention

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