Computed tomography vs. magnetic resonance imaging of acute bacterial sinusitis: A rabbit model

Kerschner, Joseph E.; Cruz, Michael J.; Beste, David J.; Donahue, Kathleen M.; Kehl, K. Sue

doi:10.1053/ajot.2000.9874

Cited by 21 publications

(16 citation statements)

References 15 publications

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“…The anatomical features of normal rabbit paranasal sinuses and their similarities to those of humans were investigated, and the maxillary sinuses were reported to be suitable for experiments because they are large [3,4]. One study compared CT and MRI for imaging sinusitis in rabbits and concluded that CT was more useful [2].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis

Özcan¹,

Özcan²,

Selçuk³

et al. 2011

Indian J Otolaryngol Head Neck Surg

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The aim of this study was to investigate and compare histopathological and computerized tomographic (CT) findings of experimental acute sinusitis in an animal model. The noses of five healthy rabbits were inoculated with a gelatin sponge impregnated with a solution containing Staphylococcus aureus, and one healthy rabbit acted as the control. The animals were sacrificed on the tenth day, following the acquisition of paranasal CT scans. Specimens were obtained from the lateral nasal walls, and the ethmoid and maxillary sinuses of the animals for histopathological examination. Histopathological and CT findings were compared. Various degrees of epithelial disorganization, foci of ruptured epithelial cells, and inflammatory cell infiltration in the lamina propria were seen in the histopathological examinations of the five study rabbits, and mucosal thickening and soft tissue density were noted in their CTs. There was no correlation between the histopathological and CT findings. It was shown that CT did not reflect the acute changes in the sinus mucosa. Patients with chronic sinusitis must be evaluated for a chronic process. Computerized tomographic scans should not be obtained in acute sinusitis cases. In this way, both unnecessary radiation exposure and economic waste can be avoided.

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Section: Discussionmentioning

confidence: 99%

“…Kerschner et al [2] compared CT and magnetic resonance imaging (MRI) for the imaging of normal paranasal sinuses and sinusitis in rabbits. To the best of our knowledge the literature does not contain any studies that have investigated the correlation between histopathological and radiological findings in experimental rabbit sinusitis.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis

Özcan¹,

Özcan²,

Selçuk³

et al. 2011

Indian J Otolaryngol Head Neck Surg

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“…En modelos animales el empleo de esta técnica ha sido utilizado en estudios relacionados con la rinosinusitis aguda para realizar un seguimiento de la enfermedad [39], pero la aplicación de la técnica CT en modelos animales para estudiar patologías del sistema respiratorio se ha centrado principalmente en diagnóstico y la evolución del cáncer pulmonar [40,41,42]. Este estudio aporta la novedad de usar esta técnica en un modelo animal para diagnosticar y seguir la evolución de la rinosinusitis crónica asociada a poliposis nasal con el fin de evitar la necesidad de sacrificar a los sujetos.…”

Section: Discusión De Los Resultadosunclassified

Digital Signal Processing Techniques to Improve Time Resolution in Positron Emission Tomography

Monzó

Esteve

Lerche

et al. 2011

IEEE Trans. Nucl. Sci.

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Rhinosinusitis is an inflammatory and obstructive process that affects the nasal cavity and sinuses. It's called chronic rhinosinusitis (CRS) when the disease lasts beyond 12 weeks. CRS can be associated with nasal polyps (CRSwNP) or not (CRSsNP). CRSwNP is a disease with high morbidity characterized by the existence of neoplastic structures that cause airways obstruction. Polyps are formed by the infiltration of inflammatory cells. Current treatments are ineffective in many of the patients having to undergo repeated surgical procedures therefore the developing of new and more effective drugs are necessary. Research in animal models is currently limited by the lack of diagnostic and disease monitoring methods without sacrificing animals. This study evaluates the effectiveness of the analysis of images carried out by computed tomography (CT) and positron emission tomography (PET) techniques in the diagnosis and monitoring of CSR-PN in an animal model. This animal model of the disease was obtained by an instillations protocol with ovalbumin as a sensitizer and Staphylococcus aureus enterotoxin B as inducing agent. CT technique is based on the ability of penetration of x-rays for detecting changes in tissue density. PET technique has the ability to calculate the glucose uptake by a homologous radiolabel. Tissue density and glucose uptake are properties that are altered in the course of a severe inflammatory process. The results obtained confirm the validity of these techniques to determine the existence of an inflammatory process and neoplastic structures in the developed disease model. The results obtained by the histological post-mortem analysis techniques corroborated this conclusion. It can be said that the use of CT and PET techniques is an effective method for determining and monitoring the evolution of CSRwPN in animal models in vivo, allowing the research into effective treatments for the disease. AgradecimientosEste trabajo es posible gracias a Xavi, quien creyó desde un primer momento que yo era la persona indicada para llevarlo a cabo y siempre sacó un momento para guiarme y aconsejarme en cada uno de los pasos de su realización.Mi agradecimiento, también, a los compañeros de la Fundación, que tanto me han ayudado a conseguir terminar un proyecto tan largo como este, en el tiempo estipulado, permitiéndome compaginarlo con el curso, así como prestándome su ayuda incondicional cuando me surgía alguna duda o me faltaba algún dato para poder seguir avanzando.A Rafa por ofrecerse a tutorizar este trabajo, permitiéndome poder desarrollarlo y defenderlo ante un tribunal.Por supuesto necesito también agradecer su apoyo a mi familia y amigos, especialmente a mi madre y a mi novia, Inma, pues sin su ayuda me hubiera sido mucho más difícil avanzar durante este largo periodo de trabajo, animándome siempre, ayudando cuando podían hacerlo y recordándome que a veces lo mejor para seguir a delante es despejarse un poco.Por último quiero dar gracias a mi padre por enseñarme, junto a mi madre, a ser lo que soy ho...

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“…The New Zealand white rabbit is a currently accepted species for experimental sinusitis 8–11 . Although differences between the rabbit and human physiology are known, this animal is nonetheless a useful model for sinus disease in the absence of a superior alternative.…”

Section: Methodsmentioning

confidence: 99%

Chondroitin Sulfate Hydrogel and Wound Healing in Rabbit Maxillary Sinus Mucosa

et al. 2004

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Despite some limitations, the New Zealand white rabbit is an effective model for the study of sinonasal wound healing. CS hydrogel accelerates wound healing in sinonasal mucosa at a 4-day endpoint. We propose that the CS hydrogel acts as a surrogate extracellular matrix, serving as a repository for cytokines and growth factors produced by the regenerating mucosa. It may also provide a structural framework for fibroblasts and epithelial regeneration. Further study is necessary to establish this relationship.

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Computed tomography vs. magnetic resonance imaging of acute bacterial sinusitis: A rabbit model

Cited by 21 publications

References 15 publications

Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis

Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis

Digital Signal Processing Techniques to Improve Time Resolution in Positron Emission Tomography

Chondroitin Sulfate Hydrogel and Wound Healing in Rabbit Maxillary Sinus Mucosa

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