Computed tomography scan assessment of lung disease in primary immunodeficiencies

Newson, Tim; Chippindale, A.J.; Cant, Andrew J.

doi:10.1007/s004310051004

Cited by 18 publications

(18 citation statements)

References 7 publications

(9 reference statements)

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“…Development of bronchiectasis is a serious medical problem (32,41), and all patients with persistent purulent sputum should be assessed and managed, jointly with a chest physician, to prevent progressive lung damage and to monitor functional impairment (12). Despite full replacement immunoglobulin therapy, patients with chronic chest infections always require physiotherapy, antibiotic therapy, bronchodilators, and local anti-inflammatory agents, if progression of lung damage is to be arrested.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Immunological Features of 65 Iranian Patients with Common Variable Immunodeficiency

Aghamohammadi

Farhoudi

Moin

et al. 2005

Clin Vaccine Immunol

111

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Common variable immunodeficiency (CVID) is a primary immunodeficiency disease characterized by hypogammaglobulinemia and recurrent bacterial infections. The records of 65 patients with CVID (37 males and 28 females) in the age range of 24 to 537 months were reviewed. By the year 2003, 11 patients had died and seven patients could not be located. The total follow-up period was 221 patient-years. The median diagnostic delay (time between onset and diagnosis) in our patient group was 60 months. At the time of diagnosis, the baseline serum immunoglobulin G (IgG), IgM, and IgA levels were below the level normal for the patients' age; the medians for this group were 120, 10, and 0 mg/dl, respectively. All of the patients presented with infectious diseases at the time of onset, the most common of which were otitis media, diarrhea, pneumonia, and sinusitis. Acute and recurrent infections were also found in almost all of the patients, particularly involving respiratory and gastrointestinal systems. The most common infections, before diagnosis and during follow-up, were pneumonia, acute diarrhea, acute sinusitis, and otitis media. CVID should be considered in any patient with a history of recurrent infections and decreased levels of all serum immunoglobulin isotypes.

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Section: Discussionmentioning

confidence: 99%

Clinical and Immunological Features of 65 Iranian Patients with Common Variable Immunodeficiency

Aghamohammadi

Farhoudi

Moin

et al. 2005

Clin Vaccine Immunol

111

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“…Those studies suggest that some paediatric CVID patients may already suffer from AD. Severity and frequency are typically lower than in adult CVID patients [22][23][24], possibly because children have experienced fewer cumulative respiratory tract infections than adults. ILD also occurs in the paediatric CVID population [25].…”

Section: Introductionmentioning

confidence: 99%

Airway and interstitial lung disease are distinct entities in paediatric common variable immunodeficiency

Ven

Jong

Konijnenburg

et al. 2011

Clinical and Experimental Immunology

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SummaryCommon variable immunodeficiency (CVID) is a common primary immune deficiency, caused by undefined defects in lymphocyte function, and is treated routinely by immunoglobulin substitution. CVID complications include airway disease (AD) and interstitial lung disease (ILD). It was not known if AD and ILD in CVID have a common immunological aetiology and should be considered separate features of the same disease, or as distinct syndromes that require specialized monitoring and treatment. We used high-resolution computed tomography (CT) to diagnose AD or ILD in paediatric CVID patients. Spirometry and body plethysmography did not differentiate between ILD and AD. Patients with AD (n = 11, 20%) developed more pneumonias while children with ILD (n = 8, 15%) showed immune dysregulation characterized by autoimmune complications, more severe memory B cell reduction and expansion of non-naive cytotoxic T cells. In conclusion, ILD and AD in CVID have dissimilar clinical and immunological characteristics, suggesting distinct aetiology requiring tailored monitoring and treatment of these patient subgroups.

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“…This is not new, 28,[34][35][36][37][38][39][40] because CT is the standard method for diagnosing bronchiectasis. 8,28,34,[37][38][39]41 Of interest are cases in which bronchiectasis was not suspected but was found with CT, which contributed to the yield of CT in the other groups.…”

Section: Discussionmentioning

confidence: 95%

Use and Yield of Chest Computed Tomography in the Diagnostic Evaluation of Pediatric Lung Disease

et al. 2009

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Computed tomography scan assessment of lung disease in primary immunodeficiencies

Abstract: CT scans have a valuable role in assessing lung disease in children with primary immunodeficiencies and will detect important changes not visible on CXR.

Cited by 18 publications

References 7 publications

Clinical and Immunological Features of 65 Iranian Patients with Common Variable Immunodeficiency

Clinical and Immunological Features of 65 Iranian Patients with Common Variable Immunodeficiency

Airway and interstitial lung disease are distinct entities in paediatric common variable immunodeficiency

Use and Yield of Chest Computed Tomography in the Diagnostic Evaluation of Pediatric Lung Disease

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