Computed Tomography, Positron Emission Tomography, Positron Emission Tomography/Computed Tomography, and Magnetic Resonance Imaging for Staging of Limited Pleural Mesothelioma

Plathow, Christian; Staab, Adrian; Schmaehl, Astrid; Aschoff, Philip; Zuna, I.; Pfannenberg, Christina; Peter, Schlemmer Heinz; Eschmann, Susanne Martina; Klopp, Michael

doi:10.1097/rli.0b013e3181817b3d

Cited by 84 publications

(55 citation statements)

References 37 publications

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“…In patients with late diagnosis and early stage MPM, the occult metastasis rate defined by PET-CT is 15%. Moreover, in PET-CT, high standardized uptake value ratios (SUVmax) are related to poor prognosis (Flores et al, 2003;Plathow et al, 2008). In our study, no relevance was detected between the SUVmax value shown by PET-CT before chemotherapy and progressionfree survival.…”

Section: Discussionmentioning

confidence: 36%

Oral Cyclophosphamide and Etoposide in Treatment of Malignant Pleural Mesothelioma

Gündüz¹,

Mutlu²,

Göksu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 36%

Oral Cyclophosphamide and Etoposide in Treatment of Malignant Pleural Mesothelioma

Gündüz¹,

Mutlu²,

Göksu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…It can play a role in differentiating benign from malignant lesions and help target the most suitable lesion for biopsy (10). In addition, it has been shown to be effective in pre-operative imaging, particularly with regards to detecting distant metastases (11,12). Given the diffuse, infiltrative nature and asymmetric growth pattern of MPM, measuring response to treatment with CT is extremely difficult.…”

Section: Discussionmentioning

confidence: 99%

F-18 FDG PET-CT Influences Target Delineation When Combined With Standard CT-Based Radiotherapy Planning in the Palliative Setting in Malignant Pleural Mesothelioma; an Exploratory Study

Leod

Stobo

O’Rourke

et al. 2015

Rep Radiother Oncol

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Background: Positron emission tomography computerized tomography (PET-CT) is useful in radiotherapy planning for lung cancer. However, its role in malignant pleural mesothelioma (MPM) is unknown. Objectives: This exploratory study investigated the possible role for PET-CT in radiotherapy planning for MPM. Patients and Methods: Patients receiving radiotherapy for the treatment of pain in MPM, had fluorodeoxyglucose (FDG) PET-CT scanning in addition to their standard CT scan. PET-CT images were then fused with CT planning images, termed Planning-PET-CT. Target volume delineation was undertaken first using CT and subsequently incorporated Planning-PET-CT. Planning treatment volume (PTV), conformity index (CI), mean distance to conformity (MDC), center of gravity distance (CGD) and standard uptake values (SUV) were examined. Results: Sixteen patients were recruited into the study. PET-CT upstaged nine patients. No association between SUV max and either survival or pain response was seen. Volumes contoured using Planning-PET-CT differed markedly from those outlined using CT alone as shown by the following parameters: CI = 0.3 (0.24 -0.38). ). The median percentage of over contouring was 44.00% (34.33 -72.50) with 46.67% under contoured (34.00 -55.00). Conclusions: PET-CT alters the position of the PTV in MPM and upstaged a proportion of patients. Further work to elucidate the role of Planning-PET-CT in target volume definition is justified.

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“…In order to stage MPM and decide on treatment options, imaging modalities such as MSCT, MRI, and positron emission tomography-computed tomography (PET-CT) are employed (8,9). Due to the diffusion of water molecules in tissues, DWI can reveal tissue characteristics.…”

Section: Discussionmentioning

confidence: 99%

Staged Surgical Treatment in an Infant with Huge Aortopulmonary Window Presenting with Severe Pulmonary Hypertension and Recurrent Pulmonary Infection

Özyurt¹,

Tunçay²,

Tekerek³

et al. 2015

Erciyes Med J

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Objective: The aim of this study was to evaluate the role of diffusion-weighted magnetic resonance imaging (dMRI) in differentiating between diffuse malignant and benign pleural thickening in asbestos-related pleural diseases.Materials and Methods: Sixty-two patients were included in the study. Thirty-two had a benign form and 30 had malignant pleural mesothelioma (MPM). The patient files and records belonging to those who underwent dMRI on a 1.5 T MR system between May 2014 and January 2016 in our clinic were examined retrospectively. The dMRI was performed with 0, 500, and 1000 mm 2 /s b-values. The apparent diffusion coefficient (ADC) map was generated, and means ADC values were determined from measurements of pleural thickening. Results:The mean ADC values were 1.94±0.09×10-3 mm 2 /s and 0.84±0.05×10 -3 mm 2 /s in benign pleural disease and MPM, respectively. The mean ADC value in the malignant group was significantly lower than in the benign group (p<0.05). Conclusion:Our results show that dMRI and ADC values are useful for differentiating between benign and malignant pleural thickening in asbestos-related pleural diseases. dMRI gives clues for the interpretation of whether pleural thickening is benign or malignant and can assist in the early detection of MPM.

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Computed Tomography, Positron Emission Tomography, Positron Emission Tomography/Computed Tomography, and Magnetic Resonance Imaging for Staging of Limited Pleural Mesothelioma

Abstract: PET/CT makes it possible to stage patients with limited MPM with high accuracy and low interobserver variability.

Cited by 84 publications

References 37 publications

Oral Cyclophosphamide and Etoposide in Treatment of Malignant Pleural Mesothelioma

Oral Cyclophosphamide and Etoposide in Treatment of Malignant Pleural Mesothelioma

F-18 FDG PET-CT Influences Target Delineation When Combined With Standard CT-Based Radiotherapy Planning in the Palliative Setting in Malignant Pleural Mesothelioma; an Exploratory Study

Staged Surgical Treatment in an Infant with Huge Aortopulmonary Window Presenting with Severe Pulmonary Hypertension and Recurrent Pulmonary Infection

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