Computed Tomography-Pathologic Assessment of Laser-Induced Necrosis in Rat Liver

Amin, Zahir; Thurrell, Wendy; Spencer, G M; Harries, Simon; Grant, William E.; Bown, Stephen G.; Lees, W. R.

doi:10.1097/00004424-199312000-00014

Cited by 14 publications

(6 citation statements)

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“…Real‐time CT is inaccurate in detecting the early signs of laser‐induced tissue injury. However, contrast‐enhanced CT performed 24 h after ILT identifies tissue necrosis as non‐perfused areas, and correlates closely with histological findings84. Residual disease appears as a region of contrast enhancement adjacent to non‐perfused tissue.…”

Section: Clinical Principlessupporting

confidence: 58%

“…Residual disease appears as a region of contrast enhancement adjacent to non‐perfused tissue. The margins of necrotic tissue become indiscrete within a few days of therapy because of inflammatory changes84. Once inflammatory changes resolve a few weeks later, early local recurrence is clearly identified as a contrast‐enhanced region adjacent to an area of necrosis.…”

Section: Clinical Principlesmentioning

confidence: 99%

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Rearrangement of a (Dithiolato)platinum(II) Complex Formed by Reaction of Cyclic Disulfide 7,8‐Dithiabicyclo[4.2.1]nona‐2,4‐diene with a Platinum(0) Complex: Oxidation of the Rearranged (Dithiolato)platinum(II) Complex

Ishii

Kashiura

Hayashi

et al. 2007

Chemistry A European J

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Reaction of the title bicyclic disulfide 16 with [(Ph3P)2Pt(eta2-C2H4)] (2) yielded the corresponding (dithiolato)platinum(II) complex 17 by oxidative addition. The initial product 17 isomerized at room temperature in a [1,5]-sulfur rearrangement to give another (dithiolato)platinum(II) complex 18 in high isolated yield. Oxidation reactions of 18 with dimethyldioxirane (DMD) provided (sulfenato-thiolato)platinum(II) 23, (sulfinato-thiolato)platinum(II) 24, (sulfenato-sulfinato)platinum(II) 25, and (disulfinato)platinum(II) 26 complexes, the structures of which were elucidated by NMR spectroscopy and X-ray crystallography. The oxidation process took place regioselectively in the first step and chemoselectively in the second. The selectivities are discussed.

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Section: Clinical Principlessupporting

confidence: 58%

Section: Clinical Principlesmentioning

confidence: 99%

Rearrangement of a (Dithiolato)platinum(II) Complex Formed by Reaction of Cyclic Disulfide 7,8‐Dithiabicyclo[4.2.1]nona‐2,4‐diene with a Platinum(0) Complex: Oxidation of the Rearranged (Dithiolato)platinum(II) Complex

Ishii

Kashiura

Hayashi

et al. 2007

Chemistry A European J

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“…Given the need for complete ablation in 3D with multiple overlapping treatments and the unpredictability of RF, we find intra-procedural monitoring a useful guide in ablation. The use of intra-procedural CT has been validated previously [13,14]. Other groups working in high field MRI use contrast enhancement at the end of the procedure; gadolinium-enhanced MR and contrast-enhanced CT provide very similar information [26].…”

Section: Groupmentioning

confidence: 99%

“…US was used to monitor the distribution of the bubble cloud. Intra-procedural contrast-enhanced CT scans provided immediate feedback as to the extent of ablation, and can show areas of residual tumour or areas where there is an inadequate margin [13,14]. These areas were then treated immediately.…”

Section: Technical Detailsmentioning

confidence: 99%

Radio-frequency ablation of colorectal liver metastases in 167 patients

2004

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The objective of this paper is to report our results from a prospective study of 167 patients with colorectal liver metastases treated with radio-frequency ablation (RFA). Three hundred fifty-four treatments were performed in 167 patients, 99 males, mean age 57 years (34-87). The mean number of metastases was 4.1 (1-27). The mean maximum diameter was 3.9 cm (1-12). Fifty-one (31%) had stable/treated extra-hepatic disease. Treatments were performed under general anaesthesia using US and CT guidance and single or cluster water-cooled electrodes (Valleylab, Boulder, CO). All patients had been rejected for or had refused surgical resection. Eighty percent received chemotherapy. Survival data were stratified by tumour burden at the time of first RFA. The mean number of RFA treatments was 2.1 (1-7). During a mean follow-up of 17 months (0-89), 72 developed new liver metastases and 71 developed progressive extra-hepatic disease. There were 14/354 (4%) major local complications and 22/354 (6%) minor local complications. For patients with < or =5 metastases, maximum diameter < or =5 cm and no extra-hepatic disease, the 5-year survival from the time of diagnosis was 30% and from the time of first thermal ablation was 26%. Given that the 5-year survival for operable patients is a median of 32%, our 5-year survival of 30% is promising.

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“…Studies in animal models have been performed using tumour-bearing rodents 27,54 and rabbits 55,56 , as well as in rodents 57,58 , dogs 17 and pigs 44,45,48,59±61 with normal livers. In the tumour models the cytotoxicity of ILC was studied; the normal-liver models allowed strategies to increase coagulation volume at human scale to be investigated.…”

Section: Studies In Experimental Animal Modelsmentioning

confidence: 99%

Interstitial laser coagulation for hepatic tumours

Heisterkamp¹,

Hillegersberg²,

Ijzermans³

1999

British Journal of Surgery

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Background: The potential role of interstitial laser coagulation (ILC) for patients with irresectable hepatic tumours is currently being investigated. Since its introduction in 1983 it has evolved into an innovative minimally invasive technique. Methods: On the basis of a Medline literature search and the authors' experience, the principles, current state and prospects of ILC for hepatic tumours are reviewed. Results: Animal studies and early clinical studies have shown the safety and feasibility of ILC. The site of interest can be approached at laparoscopy or percutaneously and treatment is easily repeatable. Recent advances include the use of fibres with a cylindrical diffusing light‐emitting tip, the length of which is adaptable to tumour diameter, water‐cooled fibre systems, simultaneous multiple fibre application, and hepatic inflow occlusion during laser treatment. ILC allows complete destruction of tumours up to 5 cm in diameter. Currently a limitation is the lack of reliable real‐time monitoring of laser‐induced effects but progress in magnetic resonance imaging techniques should allow accurate temperature measurements to be obtained rapidly during treatment. However, the actual benefit of ILC in terms of patient survival remains to be investigated. Conclusion: In terms of tools and experience, ILC has now been developed sufficiently to study its effect on survival of patients with irresectable hepatic tumours. © 1999 British Journal of Surgery Society Ltd

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Computed Tomography-Pathologic Assessment of Laser-Induced Necrosis in Rat Liver

Cited by 14 publications

References 0 publications

Rearrangement of a (Dithiolato)platinum(II) Complex Formed by Reaction of Cyclic Disulfide 7,8‐Dithiabicyclo[4.2.1]nona‐2,4‐diene with a Platinum(0) Complex: Oxidation of the Rearranged (Dithiolato)platinum(II) Complex

Rearrangement of a (Dithiolato)platinum(II) Complex Formed by Reaction of Cyclic Disulfide 7,8‐Dithiabicyclo[4.2.1]nona‐2,4‐diene with a Platinum(0) Complex: Oxidation of the Rearranged (Dithiolato)platinum(II) Complex

Radio-frequency ablation of colorectal liver metastases in 167 patients

Interstitial laser coagulation for hepatic tumours

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