Computed-Tomography of the Brain and Neuropsychological Assessment of Alcoholic Patients

Bergman, Hans; Borg, Stefan; Hindmarsh, T; Ideström, Carl-Magnus; Mützell, Sture

doi:10.1007/978-1-4684-3632-7_57

Cited by 34 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is supported by computed tomography (CT) findings demonstrating cerebral ventricular enlargement and cortical atrophy in alcoholic patients (6). Cortical atrophy seems to be present early in the dependency process, while ventricular changes increase gradually with age and drinking years (7,8).…”

mentioning

confidence: 75%

PET determination of regional cerebral glucose metabolism in alcohol‐dependent men and healthy controls using ¹¹C‐glucose

Wik

Borg

Sjögren

et al. 1988

Acta Psychiatr Scand

View full text Add to dashboard Cite

Regional brain glucose metabolism was determined in 9 male alcohol-dependent inpatients and 12 male healthy controls. All the patients were socially impaired by the alcohol abuse. All the subjects had abstained from alcohol and drugs for more than four weeks before entering the study. Brain glucose metabolism was determined by positron emission tomography (PET) with 11C-glucose as the tracer. Regions of interest were drawn on displayed computed tomographic (CT) images of the brain. Regions were transferred to corresponding PET slices, allowing the determination of regional glucose metabolism. In the healthy volunteers there was a reduction in glucose metabolism with age. In 11 of the 19 brain regions examined, the alcoholics had a 20% to 30% lower glucose metabolism than the controls. This was true for both cortical and subcortical structures. The distribution of relative regional metabolic rates indicated that parietal cortical areas were most affected. Atrophic changes as shown by CT were not correlated to the reduced metabolism in the alcohol-dependent patients.

show abstract

mentioning

confidence: 75%

PET determination of regional cerebral glucose metabolism in alcohol‐dependent men and healthy controls using ¹¹C‐glucose

Wik

Borg

Sjögren

et al. 1988

Acta Psychiatr Scand

View full text Add to dashboard Cite

show abstract

“…On neuropsychological tests, alcohol abusers without known head injury have shown a consistent pattern of diminished performance on tasks of memory and learning, visualspatial abilities, abstract reasoning, and problem solving, while performing at relatively normal levels on measures of immediate memory (Bergman et al, 1980;Bondi et al, 1998;Browning et al, 1992;Cala et al, 1978;Chick et al, 1989;Goldstein & Shelly, 1980;Jernigan et al, 1991b;Leckliter & Matarazzo, 1989;Mearns & Lees-Haley, 1993;Moss et al, 1994;Shear et al, 1992;Tarter et al, 1995). Similar deficits may be associated with polysubstance abuse (Ardila et al, 1991;Freilich & Byrne, 1992;Grant et al, 1978;Horner, 1997;Mittenberg & Motta, 1993;Moss et al, 1994;O'Malley et al, 1992;Purcell et al, 1995;Rosselli & Ardila, 1996;Sweeney et al, 1989).…”

Section: Performance On Neuropsychological Measuresmentioning

confidence: 90%

Polysubstance abuse and traumatic brain injury: Quantitative magnetic resonance imaging and neuropsychological outcome in older adolescents and young adults

Barker

Bigler

Johnson

et al. 1999

J Int Neuropsychol Soc

View full text Add to dashboard Cite

Few studies have examined the consequences of alcohol and drug abuse on TBI though they commonly co-occur. Both TBI and substance abuse independently result in neuropathological changes in the brain such as ventricular enlargement and cortical atrophy, thus it is reasonable to hypothesize that the combination of the two would result in more significant cerebral damage. In this study, 3 groups of patients-traumatically brain injured (TBI) with substance abuse~N 5 19), TBI without substance abuse~N 5 19), and substance abuse with no TBI~N 5 16)-were compared with normal controls~N 5 20) on several quantitative MRI (QMRI) measures. Since TBI most frequently occurs in older adolescents and young men, we examined only male participants between 16 and 30 years of age. Comparing young substance abusers to controls resulted in no QMRI differences. When controlling for head injury severity, the effects of substance abuse in combination with TBI resulted in greater atrophic changes than seen in any other group. TBI and substance abuse patients' neuropsychological test performances also were examined, and no differences were found among patient groups on any measures. These findings have implications for the deleterious interaction of substance abuse combining with TBI to result in greater neuropathological changes that can be detected by QMRI techniques. (JINS, 1999, 5, 593-608.)

show abstract

“…The reason for using this type of equipment was that the previous reference group was examined with this scanner and that experience in the analysis had been gathered. The size of the ventricles was measured as the transverse diameter of the anterior horns in relation to the largest transverse skull diameter, and the maximum width of the third ventricle (3,4). The measurements were carried out with Vernier calipers directly on Polaroid films.…”

Section: Methodsmentioning

confidence: 99%

Computed Tomography of the Brain in Cases with Venous Vasculitis Compared with an Age-Matched Reference Group

Hannerz¹,

Bergstrand²,

Berggren³

et al. 1988

Acta Radiol

View full text Add to dashboard Cite

Patients with a particular, steroid-sensitive headache and often characteristic pathology at orbital phlebography, have been suggested to suffer from venous vasculitis. Fifty such patients were examined with computed tomography (CT) of the brain. The findings were compared with those of an age-matched reference group selected at random to represent normal subjects. The CT examinations were analyzed with respect to size of lateral ventricles and signs of atrophy. In both groups, there was a significant increase of atrophy with age. There was also a significantly higher degree of atrophy in the patient group as compared with the reference group. The findings indicate that the supposedly underlying venous vasculitis is related to early aging and atrophy of the brain.

show abstract

Computed-Tomography of the Brain and Neuropsychological Assessment of Alcoholic Patients

Cited by 34 publications

References 8 publications

PET determination of regional cerebral glucose metabolism in alcohol‐dependent men and healthy controls using ¹¹C‐glucose

PET determination of regional cerebral glucose metabolism in alcohol‐dependent men and healthy controls using ¹¹C‐glucose

Polysubstance abuse and traumatic brain injury: Quantitative magnetic resonance imaging and neuropsychological outcome in older adolescents and young adults

Computed Tomography of the Brain in Cases with Venous Vasculitis Compared with an Age-Matched Reference Group

Contact Info

Product

Resources

About

Computed-Tomography of the Brain and Neuropsychological Assessment of Alcoholic Patients

Cited by 34 publications

References 8 publications

PET determination of regional cerebral glucose metabolism in alcohol‐dependent men and healthy controls using 11C‐glucose

PET determination of regional cerebral glucose metabolism in alcohol‐dependent men and healthy controls using 11C‐glucose

Polysubstance abuse and traumatic brain injury: Quantitative magnetic resonance imaging and neuropsychological outcome in older adolescents and young adults

Computed Tomography of the Brain in Cases with Venous Vasculitis Compared with an Age-Matched Reference Group

Contact Info

Product

Resources

About

PET determination of regional cerebral glucose metabolism in alcohol‐dependent men and healthy controls using ¹¹C‐glucose

PET determination of regional cerebral glucose metabolism in alcohol‐dependent men and healthy controls using ¹¹C‐glucose