Computed tomography of the anterior mediastinum in myasthenia gravis. A radiologic-pathologic correlative study.

Fon, Gerald T.; Bein, ME; Mancuso, A A; Keesey, John; Lupetin, Anthony R.; Wong, Winstan

doi:10.1148/radiology.142.1.7053523

Cited by 45 publications

(9 citation statements)

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“…However CT scan displayed only a small advantage over CXR or tomography at the hilum as has been found for other tumours within the chest (Fong et al, 1982;Muhm et al, 1979;Osbourne et al, 1982;Underwood et al, 1979;Baron et al, 1981). The low incidence of pericardial and pleural infiltration reflects the early stage in the disease at which most of these patients had been diagnosed.…”

Section: Resultsmentioning

confidence: 90%

“…CT has been found to detect more mediastinal and pulmonary disease (Fong et al, 1982;Muhm et al, 1979;Osbourne et al, 1982;Underwood et al, 1979) in patients with thymoma and bronchial carcinoma, and it has been suggested that it may improve the staging of intrathoracic lymphoma (Ellert & Kreel, 1980). Comparison has not previously been made with conventional radiography, therefore a prospective study was undertaken to determine the role of thoracic CT in the management of patients with lymphoma.…”

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confidence: 99%

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The role of computed tomography in the detection of intrathoracic lymphoma

Gallagher¹,

White²,

Tucker³

et al. 1984

Br J Cancer

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Computed tomographic scanning of the chest in 100 patients with newly diagnosed malignant lymphoma detected mediastinal lymphadenopathy (39%) and parenchymal deposits (15%) with a significantly greater sensitivity and specificity than conventional radiological techniques. This principally affected the staging and treatment of patients with limited stage disease. The stage was changed in 10/61 patients (16%) with Stages I-III prior to CT scan and treatment was altered in 11/29 (38%) patients for whom radiation was the treatment of choice. Complete remissions as defined by CT scan have been more durable than those defined by CXR alone. Images Figure 1 Figure 2 Figure 3 Figure 4

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Section: Resultsmentioning

confidence: 90%

mentioning

confidence: 99%

The role of computed tomography in the detection of intrathoracic lymphoma

Gallagher¹,

White²,

Tucker³

et al. 1984

Br J Cancer

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“…Pathologically, thymoma can be classified as Non-invasive (benign) or invasive (malignant) thymoma. Only about one-third of thymoma is malignant which is characterized by invasion of tumor into mediastinal fat and mediastinal structures rather than the basis of histological 9 . On CT scan, Thymoma can be visualized as a well-defined homogenous or heterogeneous attenuation depending on the presence of hemorrhage, necrosis or cyst formation 10 .…”

Section: Discussionmentioning

confidence: 99%

Computed Tomography Differential Features of Anterior Mediastinal Thymoma and Lymphoma

Thapa

Wen

et al. 2017

Int. j. endorsing health sci. res.

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Background To identify the CT features of anterior mediastinal thymoma and lymphoma and evaluate CT findings that may help in suggesting specific diagnosis among these tumors. Method A total of fifty-eight chest CT scan studies with pathological diagnosis of thymoma (n = 30) and lymphoma (n =28) were retrospectively reviewed by two radiologists who were blind to the pathological results. The CT features showing cyst and calcification within the lesion, contrast enhancement, relation with pleura and adjacent vessels, bone invasion and lymph node enlargement were evaluated. Results In lymphoma (67.9%), the presence of associated mediastinal lymphadenopathy was significantly compared to thymoma. (P < 0.05). The presence of calcification within the lesion was significantly found in thymoma than the lymphoma (p <0.05). The presence of adjacent vessels relationship within the lesion was higher in lymphoma than the thymoma. (p <0.05) The remaining CT findings showed no significant difference among these diseases (p > 0.05). Conclusion In conclusion age, lymph nodes involvement, calcification and relationship to adjacent vessels on CT scan will be helpful to give specific diagnosis on anterior mediastinum lymphoma and thymoma. .

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“…Studies assessing the thymus often included patients with thymic hyperplasia or thymic carcinoma and did not provide statistical analysis for the thymoma patients alone; they usually compared these tumors by the WHO classification system rather than by the Masaoka-Koga staging system used in the clinical setting. [33][34][35][36][37][38] To improve our preoperative staging of thymoma, there have been attempts to study the morphology of the primary tumor as it compares with Masaoka staging. [39][40][41] In 2 retrospective studies assessing 50 and 58 patients with thymoma, 40,41 the authors tried to distinguish stage I thymoma from more advanced disease (stages II to IV) and found that partial or complete obliteration of fat planes around the tumor was not helpful in distinguishing stage I from higher stages.…”

Section: Ctmentioning

confidence: 99%

Advances in Thymoma Imaging

Marom

2013

Journal of Thoracic Imaging

103

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Thymoma is the most common primary neoplasm of the anterior mediastinum, but it accounts for <1% of all adult malignancies. It is the most common of the thymic epithelial neoplasms, which, in addition to thymoma, include thymic carcinoma and thymic carcinoid. Because of the rarity of thymoma, it has not been studied thoroughly. Over the last half decade, there has been increased interest in this disease, with greater international collaboration and dedicated thymic malignancy work groups; this has culminated in the formation of the International Thymic Malignancy Interest Group, instituted to provide a scientific infrastructure for the study of these lesions and foster collaborative research. Imaging plays a major role in the identification and staging of thymoma, as well as in the follow-up monitoring for its recurrence. Currently, imaging is predominantly carried out with computed tomography (CT). In selected cases, there is a role for magnetic resonance imaging and F-fluorodeoxyglucose positron emission tomography in the investigation of an anterior mediastinal mass suspected to be thymoma. Because patients with advanced thymoma receive neoadjuvant chemotherapy, radiologists should be familiar with the staging system of thymoma and the imaging features of advanced-stage thymoma to identify such patients before surgery. This review serves as an update of the recent imaging studies on thymoma, which may help in tailoring the approach to the patient with a biopsy-proven or suspected thymoma.

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Computed tomography of the anterior mediastinum in myasthenia gravis. A radiologic-pathologic correlative study.

Cited by 45 publications

References 0 publications

The role of computed tomography in the detection of intrathoracic lymphoma

The role of computed tomography in the detection of intrathoracic lymphoma

Computed Tomography Differential Features of Anterior Mediastinal Thymoma and Lymphoma

Advances in Thymoma Imaging

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