Computed tomography of diffuse lung disease: functional correlates

Hansell, David M.

doi:10.1007/s003300100880

Cited by 19 publications

(11 citation statements)

References 40 publications

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“…Per esempio, i nostri intervalli di densità non tengono in considerazione lo spazio cistico dell'honeycombing ("spazi morti"), e questo potrebbe spiegare la mancanza di correlazione con gli indici funzionali. Le dimensioni degli "spazi morti" cistici (honey-combing alla TC), contribuiscono alla mancanza di perfusione del polmone fibrotico e sono correlate alla riduzione del DL CO e meno agli indici volumetrici PFR [26][27][28]. L'indice fibrotico nel Hounsfield units due to several factors.…”

Section: Discussionunclassified

Visual score and quantitative CT indices in pulmonary fibrosis: Relationship with physiologic impairment

et al. 2007

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Section: Discussionunclassified

Visual score and quantitative CT indices in pulmonary fibrosis: Relationship with physiologic impairment

et al. 2007

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“…In most diffuse lung diseases, imaging and functional abnormalities are central to clinical evaluation [18]. None of the workers had significant abnormalities on chest radiographs, indicating that there was no subject with established ILD or fibrosis.…”

Section: Discussionmentioning

confidence: 99%

The respiratory effects of occupational polypropylene flock exposure

Atış

Tutluoğlu²,

Levent³

et al. 2005

European Respiratory Journal

113

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The present study evaluated the possible effects of exposure to polypropylene flock on respiratory health and serum cytokines in a cross-sectional study of workers from a plant in Turkey.A total of 50 polypropylene flocking workers were compared to a control group of 45 subjects. All subjects filled out a respiratory questionnaire and underwent a physical examination, a chest radiograph and pulmonary function testing, including single breath carbon monoxide diffusing capacity (DL,CO). Serum interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-a) were measured. Additionally, high resolution computed tomography (HRCT) of the chest was performed in 10 exposed workers with low DL,CO.Work-related respiratory symptoms were reported in 26% of the exposed subjects and in 13.3% of the controls. Logistic regression analysis showed that the risk of respiratory symptoms increased 3.6 fold in polypropylene flocking workers when compared to controls. Parameters of the study group, including per cent predicted: forced vital capacity, forced expiratory volume in one second, forced mid-expiratory flow 25-75% and DL,CO, were significantly lower than in controls. Multivariate analyses showed that being a polypropylene flocking worker was a predictive factor for impairment of pulmonary function. Serum IL-8 and TNF-a levels were increased in the study group compared with the controls. HRCT revealed peribronchial thickening and diffuse ground glass attenuation in some subjects.The present study suggests the presence of subtle or the beginning of interstitial lung disease in these polypropylene flocking workers.

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“…Recently, these approaches have been reviewed in depth [48], but it is beyond the scope of this article to integrate all the information.…”

Section: Lungmentioning

confidence: 99%

Radiological imaging as the basis for a simulation software of ventilation in the tracheo-bronchial tree

et al. 2002

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The inhaled route is a promising new way for administering drugs to the human body. Flow and particle deposition in the human respiratory tract depends on the individual's anatomy as well as on the drug composition. A European Framework V Program supported project is currently developing a simulation tool for assessment of drug distribution and deposition. This tool relies heavily on the input of radiological data sets, which are obtained in humans. Both high temporal and spatial resolutions are required, and CT and MRI (including hyperpolarized helium-3 MRI) are applied. The radiological data are integrated into computation fluid dynamics software, which is capable of assessing air-flow profiles and compartmental behaviours. This is complemented by pharmacokinetic models, which should result in a simulation tool that will be of use for the theoretical design of new inhaled therapies. This article describes the special imaging requirements of each region of the respiratory tract and the feasibility of these sophisticated radiological techniques with a view of using these data in a simulation model of the lung.

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Computed tomography of diffuse lung disease: functional correlates

Cited by 19 publications

References 40 publications

Visual score and quantitative CT indices in pulmonary fibrosis: Relationship with physiologic impairment

Visual score and quantitative CT indices in pulmonary fibrosis: Relationship with physiologic impairment

The respiratory effects of occupational polypropylene flock exposure

Radiological imaging as the basis for a simulation software of ventilation in the tracheo-bronchial tree

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