Computed tomography in the diagnosis of fatty liver: Total lipid content and computed tomography number.

Yajima, Yoshiaki; Narui, Takashi; Ishii, Motoyasu; Abe, Ryuzo; Ohtsuki, Masao; Gotō, Yoshio; Endo, Satoshi; Yamada, Kenji; Ito, Masako

doi:10.1620/tjem.136.337

Cited by 53 publications

(36 citation statements)

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“…According to this method, the lower the number of HUs, the lower the tissue density and therefore the greater the fat content [14]. Assessment was carried out by a single investigator who was blinded to subjects' status (i.e.…”

Section: Computed Tomography Scanningmentioning

confidence: 99%

Sleep apnoea and visceral adiposity in middle-aged male and female subjects

et al. 2012

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In obese male subjects, visceral adiposity has been associated with obstructive sleep apnoea (OSA), while studies in overweight males and females are limited. Our goal was to examine the association between OSA and visceral fat in a relatively nonobese population and assess the effects of 2 months placebo-controlled continuous positive airway pressure (CPAP) use on abdominal fat.81 subjects, 22 middle-aged males and 20 post-menopausal females with OSA, and 19 male and 20 female controls were studied in the sleep laboratory for four nights. Abdominal (visceral (VAT) and subcutaneous (SAT) adipose tissue) and liver fat were assessed with computed tomography. OSA patients were re-assessed post-CPAP and post sham-CPAP.Apnoeic males had significantly higher VAT than controls, while apnoeic females had higher SAT than controls. In both sexes, OSA was associated with increased liver fat. In males, apnoea was associated with VAT whereas in females it was associated with subcutaneous, visceral and total fat. CPAP did not affect abdominal and liver fat.In overweight males, visceral adiposity is associated with OSA whereas in females it is associated with global adiposity. In overweight males, our therapeutic goal should be the reduction of visceral adiposity and its metabolic correlates, whereas, in females, weight loss may be sufficient. Shortterm CPAP treatment does not affect general, abdominal or intra-hepatic adiposity.

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Section: Computed Tomography Scanningmentioning

confidence: 99%

Sleep apnoea and visceral adiposity in middle-aged male and female subjects

et al. 2012

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“…CT has been applied for evaluation of various liver diseases in human, including diagnosis of fatty liver [6]. In this study, we investigated the usefulness of CT for the diagnosis of FHL.…”

mentioning

confidence: 99%

Clinical Application of Computed Tomography for the Diagnosis of Feline Hepatic Lipidosis

Nakamura

Chen

Momoi

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. The usefulness of computed tomography (CT) for the diagnosis of feline hepatic lipidosis (FHL) was evaluated. Liver CT number was 54.7 ± 5.6 HU (mean ± SD) in 26 healthy cats. We fast 6 healthy cats for 72 hr to induced FHL experimentally and the cats were assessed by CT and serum biochemical analysis. Liver CT number of the six cats was 53.8 ± 3.0 HU before fasting, 46.8 ± 2.4 HU after fasting, and 50.2 ± 3.6 HU two weeks after restarted feeding. The decreased CT number was associated with the elevation of serum non-esterified fatty acid (NEFA) and β-hydroxybutyrate levels. These results indicate that measurement of CT number of the liver is an effective procedure for the diagnosis of FHL. KEY WORDS: computed tomography, feline hepatic lipidosis.J. Vet. Med. Sci. 67(11): 1163-1165, 2005 Feline hepatic lipidosis (FHL) is a metabolic disorder caused by excessive accumulation of triglycerides in hepatocytes that ultimately impairs liver function. Though, global surveys of feline hepatobiliary diseases have not been done, it is generally agreed that FHL is the most common liver disease in cats [7]. Diagnosis of FHL is based on cytology or histopathologic evaluation of liver specimen [5]. Hepatic biopsy can be performed by percutaneous fine-needle aspiration (FNA), but it lacks histopathological information, and regarded as least accurate diagnostic procedure for liver diseases [3,5]. In contrast, tissue biopsy with core needles, laparoscopy or laparotomy is more invasive and sometimes requires sedation or anesthesia. Moreover, histopathological estimation of fatty droplets accumulation in the hepatic tissue seems subjective.Fat is relatively radiolucent, so that objects rich in fat component are described as lower attenuation by Computed Tomography (CT) [4]. CT has been applied for evaluation of various liver diseases in human, including diagnosis of fatty liver [6]. In this study, we investigated the usefulness of CT for the diagnosis of FHL.Twenty-six clinical healthy cats and two cats with suspected lipidosis were investigated. Control cats were kept in our laboratory (n=6) or provided by the owner (n=20). These cats have normal plasma levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), asparate aminotransferase (AST) and bilirubin. CT scan was performed with multislice helical CT (Siemens Somatom 2, Siemens, Munich, Germany) at 130 kV, 60 mAs, and 5 mm slice thickness without contrast enhancement. Sedation with medetomidine-HCl (Domitor, Meiji seika, Tokyo,Japan) was performed if necessary. A transverse section image of liver was obtained at just caudal to the xiphoid process. Area of liver parenchyma was selected manually from the image to avoid blood vessels and area of inhomogeneity. The mean CT number and the standard deviation of the area were calculated with computer assisted image analyzer and expressed in Hounsfield unit (HU).CT number in control cats was 54.7 ± 5.6 HU (mean ± SD), ranged from 42.6 to 64.8 HU (Fig. 1) without significant difference between male and female cat...

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“…But there was a reversal of computed tomography (CT) number between the liver (4511) and the spleen (53H). Accordingly CT findings also suggested a fatty change of about 50% of the area in the hepatic lobules (Scherer et al 1979;Yajima et al 1982a) (Fig. 2).…”

Section: Computed Tomography Findingsmentioning

confidence: 89%

“…On the other hand, Tada et al (1979) investigated CT numbers of various diffuse liver diseases and found that a reversal of the normally higher density of the liver than the spleen could suggest the presence of fatty liver. We (Yajima et al 1982a) tried to make a strict approach in adopting biochemical measurement of total lipid content and demonstrated a better correlation between total lipid content and CT numbers than those of previous reports. Subsequently, diagnostic criteria expressed as a CT numbers were estimated from the regression formula and the result confirmed diagnostic criteria of Tada et al (1979).…”

Section: Liver Histologymentioning

confidence: 94%