Computed Tomography in the Diagnosis of Myositis Ossificans – Case Report

Nitek, Żaneta; Czwojdziński, Adam; Wolf-Kuś, Alicja; Walecki, Jerzy

doi:10.12659/pjr.890511

Cited by 3 publications

(1 citation statement)

References 8 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnetic resonance imaging and computed tomography (CT) scans are other sensitive, high-resolution imaging modalities used to detect heterotopic bone formation. 32–34 Magnetic resonance imaging can be confidently used for the diagnosis of exclusively mature HO, since the signal associated with early HO lesions is heterogeneous. 35 Both contrast-enhanced and noncontrast CT scans are used to visualize HO, depending on the location of the ectopic bone and associated soft tissue inflammation.…”

Section: Diagnostics: Ct Raman Nir Ultrasoundmentioning

confidence: 99%

The traumatic bone: trauma-induced heterotopic ossification

Dey

Wheatley

Cholok

et al. 2017

Translational Research

106

108

View full text Add to dashboard Cite

Heterotopic ossification (HO) is a common occurrence after multiple forms of extensive trauma. These include arthroplasties, traumatic brain and spinal cord injuries, extensive burns in the civilian setting, and combat-related extremity injuries in the battlefield. Irrespective of the form of trauma, heterotopic bone is typically endochondral in structure and is laid down via a cartilaginous matrix. Once formed, the heterotopic bone typically needs to be excised surgically, which may result in wound healing complications, in addition to a risk of recurrence. Refinements of existing diagnostic modalities, like micro- and nano-CT are being adapted toward early intervention. Trauma-induced HO is a consequence of aberrant wound healing, systemic and local immune system activation, infections, extensive vascularization, and innervation. This intricate molecular crosstalk culminates in activation of stem cells that initiate heterotopic endochondral ossification. Development of animal models recapitulating the unique traumatic injuries has greatly facilitated the mechanistic understanding of trauma-induced HO. These same models also serve as powerful tools to test the efficacy of small molecules which specifically target the molecular pathways underlying ectopic ossification. This review summarizes the recent advances in the molecular understanding, diagnostic and treatment modalities in the field of trauma-induced HO.

show abstract

Section: Diagnostics: Ct Raman Nir Ultrasoundmentioning

confidence: 99%

The traumatic bone: trauma-induced heterotopic ossification

Dey

Wheatley

Cholok

et al. 2017

Translational Research

106

108

View full text Add to dashboard Cite

show abstract

Abdominis rectus intramuscular myositis ossificans

Horng

Chien

2016

Formosan Journal of Surgery

View full text Add to dashboard Cite

Fibrodysplasia Ossificans Progressiva

Acosta

Fernández²

2021

J Clin Rheumatol

View full text Add to dashboard Cite

I n 2006, researchers at the University of Pennsylvania 1 mapped to chromosome 2q23-24, and a recurrent mutation in the activin receptor type 1 (ACVR1), a bone morphogenetic protein for fibrodysplasia ossificans progressiva (FOP), was identified. The FOP is a rare autosomal dominant disease that affects 1 in 2 million individuals. The diagnosis of FOP is made by the association of progressive ossifying soft tissue swellings and great toe malformations. In this sense, Kaplan et al. 2 described the plain film characteristic findings of FOP including ectopic ossifications within soft tissues, deformed shortened great toes, or prominent calcaneal spur. Osseous bridging might be seen, and computed tomography (CT) scan can provide important information about these. 3 The most common cause of death is cardiorespiratory failure as a result of thoracic insufficiency syndrome. 4 We present the case of a 22-year-old woman who presented to the emergency with worsening of her usual dyspnea associated to sore throat and cough. On examination, she presented limitation of the thoracic movements and musculoskeletal deformities. A chest radiograph revealed multiple heterotopic ossifications of soft tissue without pulmonary infiltrates (Fig. , A). In CT scan, osseous bridging is present (Fig. , B). In this patient, antibiotic treatment was started for respiratory tract symptoms and history of intermittent corticosteroid therapy for FOP. As is demonstrated in this case, radiographic findings are important as a detection method for this disease. There is no effective treatment, although bisphosphonates or corticosteroids could improve symptoms. 5 Currently, there is an increasing consensus about the necessity for further treatment research.

show abstract

Computed Tomography in the Diagnosis of Myositis Ossificans – Case Report

Cited by 3 publications

References 8 publications

The traumatic bone: trauma-induced heterotopic ossification

The traumatic bone: trauma-induced heterotopic ossification

Abdominis rectus intramuscular myositis ossificans

Fibrodysplasia Ossificans Progressiva

Contact Info

Product

Resources

About