Computed Tomography Imaging Features of Malignant “Triton” Tumor for Its Clinical Diagnosis: Report of Two Cases

Li, Yuan; Zeng, Chun; Jiang, Ning; Molloy, David P.; Peng, Qiling; Zhang, Cheng; Shi, Haoming; Chen, Dan; Wu, Qing-Chen

doi:10.21203/rs.3.rs-42437/v1

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Articles have unveiled the relationship between KC associated genetic loci (VSX1, IL1A, IL1B, COL4A3 and COL4A4) and Chinese Han ethnicity [10][11][12] . However, epidemiological study of KC among Chinese population is kind of a blank, except a research from Singapore in which only 60.3% of their subjects were made up of Chinese in 2011 and a research that simply illustrated several clinical features of Chinese KC patients in 2005 13,14 . Consequently, confusions on the severity and epidemiological factors such as positive family history, eye rubbing and atopy among Chinese KC patients are still exist.…”

Section: Introductionmentioning

confidence: 99%

Risk factors and severity of keratoconus on the East Coast of China

et al. 2022

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Purpose: This study aims to investigate the characteristics, potential risk factors and associated severity of keratoconus on the east coast of China. Methods: In this prospective case-control study, patients diagnosed with keratoconus were invited to ll in the online electronic questionnaire designed with the help of the App named WenJuanXing. Several questions like, sex, age of diagnosis and eye care habits were administered to each subject through this e-questionnaire. Corneal topographies at diagnosis taken from Pentacam were also collected.Results: 391 Chinese keratoconus outpatients were enrolled in this study, among which 159 patients were newly diagnosed. Only 3 patients (0.77%) had a positive family history of keratoconus. Atopy could be identi ed in 66.0% of our patients. A total of 357 patients (91.3%) mentioned the habit of eye rubbing, with 191 patients (48.8%) rubbing their eyes frequently. Patients with younger age at onset (P=0.005), male sex (P=0.042), frequent eye rubbing (P=0.003) and smoke (P=0.002) were found signi cantly associated with increased risk of acute hydrops. In newly diagnosed patients, 79.9% had the maximum keratometry (Kmax) more than 52D, with males and patients aged 21-30 being even more serious (P=0.009; P=0.005). Besides, in patients aged over 21, frequent eye rubbing was signi cantly associated with steeper Kmax and more severe astigmatism (all P 0.05). Conclusion:Our results suggest that frequent eye rubbing is closely related to the severity of keratoconus in Chinese patients. Chinese keratoconus patients always had much serious disease condition at the time of diagnosis. Thus, increasing the publicity of keratoconus and advocating appropriate eye care habits are needed urgently in China.

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Section: Introductionmentioning

confidence: 99%

Risk factors and severity of keratoconus on the East Coast of China

et al. 2022

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Malignant triton tumor of the anterior mediastinum: a rare tumor in a rare location

Zain

Mirchia

Hussien

et al. 2021

Radiology Case Reports

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Malignant triton tumors are an extremely aggressive form of malignant peripheral nerve sheath tumor that display rhabdomyosarcomatous features. While these tumors are extremely rare, they have a much higher incidence in patients with neurofibromatosis-1. We present a case of a 64-year-old male with neurofibromatosis-1 who presented to the hospital with sudden worsening of shortness of breath and dysphagia to solids. Radiological examination revealed a large mass in the anterior mediastinum causing significant narrowing and displacement of the upper trachea and esophagus. Biopsy of the mass, done by interventional radiology, demonstrated features of an MTT. The mass was subsequently resected but without confirmation of tumor-free margins and the patient underwent adjuvant radiation therapy. Repeat radiological examination approximately four months later revealed growing malignancy and new metastases, which eventually contributed to the patient's death seven months after his presentation to the hospital.

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Risk Factors and Severity of Keratoconus on the East Coast of China

Mou¹,

Qin²,

Huang³

et al. 2021

Preprint

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Purpose: This study aims to investigate the characteristics, potential risk factors and associated severity of keratoconus on the east coast of China. Methods: In this prospective case-control study, patients diagnosed with keratoconus were invited to fill in the online electronic questionnaire designed with the help of the App named WenJuanXing. Several questions like, sex, age of diagnosis and eye care habits were administered to each subject through this e-questionnaire. Corneal topographies at diagnosis taken from Pentacam were also collected. Results: 391 Chinese keratoconus outpatients were enrolled in this study, among which 159 patients were newly diagnosed. Only 3 patients (0.77%) had a positive family history of keratoconus. Atopy could be identified in 66.0% of our patients. A total of 357 patients (91.3%) mentioned the habit of eye rubbing, with 191 patients (48.8%) rubbing their eyes frequently. Patients with younger age at onset (P=0.005), male sex (P=0.042), frequent eye rubbing (P=0.003) and smoke (P=0.002) were found significantly associated with increased risk of acute hydrops. In newly diagnosed patients, 79.9% had the maximum keratometry (Kmax) more than 52D, with males and patients aged 21-30 being even more serious (P=0.009; P=0.005). Besides, in patients aged over 21, frequent eye rubbing was significantly associated with steeper Kmax and more severe astigmatism (all P＜0.05). Conclusion: Our results suggest that frequent eye rubbing is closely related to the severity of keratoconus in Chinese patients. Chinese keratoconus patients always had much serious disease condition at the time of diagnosis. Thus, increasing the publicity of keratoconus and advocating appropriate eye care habits are needed urgently in China.

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Computed Tomography Imaging Features of Malignant “Triton” Tumor for Its Clinical Diagnosis: Report of Two Cases

Cited by 3 publications

References 19 publications

Risk factors and severity of keratoconus on the East Coast of China

Risk factors and severity of keratoconus on the East Coast of China

Malignant triton tumor of the anterior mediastinum: a rare tumor in a rare location

Risk Factors and Severity of Keratoconus on the East Coast of China

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