Computed tomography-guided transthoracic biopsy: Factors influencing diagnostic and complication rates

Görgülü, Feride Fatma; Öksüzler, Fatma Yasemin; Arslan, Süheyla Aytaç; Arslan, Mustafa; Özsoy, İ̇brahim Ethem; Görgülü, Orhan

doi:10.1177/0300060517698064

Cited by 11 publications

(12 citation statements)

References 23 publications

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“…TBLC associated with ENB could be the best option in the diagnosis of nodules smaller than 20 mm in diameter. CT-guided transthoracic needle biopsy is an alternative to assess peripheral lesions but is associated with a higher complication rate than endoscopy [15], especially in lesions smaller than 30 mm in diameter, in which the rate of pneumothorax reaches 32.3% [16]. In our study group, the rate of bleeding and pneumothorax was particularly low, rising the interest of TBLC associated with ENB in the particular setting of small-size nodules.…”

Section: Discussionmentioning

confidence: 72%

Diagnostic Yield of Combined Pulmonary Cryobiopsies and Electromagnetic Navigation in Small Pulmonary Nodules

et al. 2018

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Background An increasing number of pulmonary nodules of unknown nature are detected as a result of screening by CT in high lung cancer risk patients. Objectives The purposes of this study were to assess the diagnostic yield of electromagnetic navigation bronchoscopy (ENB) combined with transbronchial lung cryobiopsy (TBLC) and to compare it with standard transbronchial biopsy (TBB) in pulmonary nodules of less than 2 cm in diameter. Methods We prospectively included 32 patients (18 men and 14 women, mean age 68 ± 9 years) with nodules of less than 2 cm in diameter and no metastasis at 18FDG PET-CT. The nodule position was determined by ENB, radial endobronchial ultrasonography miniprobe, and fluoroscopy. Eight samples were obtained, six by TBB and two by TBLC. Results Nodule diameter averaged 16 ± 3 mm. Twenty-five nodules were malignant and 18 were surgically resected. Surgery was avoided in four patients as the biopsies revealed a benign disease. The samples obtained by TBLC were five times larger than those by TBB. The diagnostic yields of TBLC and TBB were 69% and 38%, respectively (p=0.017). Adverse events consisted in 15 mild or moderate bleedings and one pneumothorax. Conclusions In the setting of peripheral pulmonary lesions of less than 20 mm in diameter, ENB-combined TBLC is feasible and safe, provides larger samples, and has higher diagnostic yield than TBB.

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Section: Discussionmentioning

confidence: 72%

Diagnostic Yield of Combined Pulmonary Cryobiopsies and Electromagnetic Navigation in Small Pulmonary Nodules

et al. 2018

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“…Among the diagnostic techniques, image-guided transthoracic biopsy is less invasive and cost-effective when compared with other alternative methods. In current clinical practice, CT guidance still corresponds to the golden standard method and is widely acceptable for chest physicians (5). Given the advantages of nonradiative exposure, mobile machinery, real-time mode, and cost-effectiveness, US guidance is more preferable if the "target" lesion is adjacent to the thoracic wall or thoracic inlet and is adequately displayed by US (6).…”

Section: Introductionmentioning

confidence: 99%

Clinical value of contrast-enhanced ultrasound in transthoracic biopsy of malignant anterior mediastinal masses

Han¹,

Feng²,

Xu³

et al. 2019

J Thorac Dis

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Background: Given low incidence and high heterogeneity, the treatment strategies of anterior mediastinal masses (AMMs) are diverse based on pathology. The purpose of the study is to evaluate the usefulness of contrast-enhanced ultrasound (CEUS) in transthoracic biopsy of malignant AMMs when compared with that of ultrasound (US) alone and to screen lesions that are more suitable for CEUS evaluation and guidance. Methods: We reviewed all the US-and CEUS-guided transthoracic core needle biopsy (CNB) of AMMs

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“…T he leading cause of death in patients with cancer diagnosis is lung cancer. 1 Due to the increase in the usage and availability of imaging methods, especially computed tomography (CT), the number of CT detected lung lesions has increased. Even if patients with incidental lung nodules or tumors have no symptoms, histopathological analysis is needed to obtain a specific diagnosis.…”

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confidence: 99%

Molecular characterization of carbapenem-resistant Enterobacterales in thirteen tertiary care hospitals in Saudi Arabia

et al. 2021

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BACKGROUND: Carbapenems are the antibiotics of last-resort for the treatment of bacterial infections caused by multidrug-resistant organisms. The emergence of resistance is a critical and worrisome problem for clinicians and patients. Carbapenem-resistant Enterobacterales (CRE) are spreading globally, are associated with an increased frequency of reported outbreaks in many regions, and are becoming endemic in many others. OBJECTIVES: Determine the molecular epidemiology of CRE isolates from various regions of Saudi Arabia to identify the genes encoding resistance and their clones for a better understanding of the epidemio-logical origin and national spread. DESIGN: Multicenter, cross-sectional, laboratory-based study. SETTING: Samples were collected from 13 Ministry of Health tertiary-care hospitals from five different regions of Saudi Arabia. METHODS: Isolates were tested using the GeneXpert molecular platform to classify CRE. MAIN OUTCOME MEASURES: Prevalence of various types of CRE in Saudi Arabia. SAMPLE SIZE: 519 carbapenem-resistant isolates. RESULT: Of 519 isolates, 440 (84.7%) were positive for CRE, with Klebsiella pneumoniae (410/456, 90%) being the most commonly isolated pathogen. The distribution of the CRE-positive K pneumoniae resistance genes was as follows: OXA-48 (n=292, 71.2%), NDM-1 (n=85, 20.7%), and NDM+OXA-48 (n=33, 8%). The highest percentage of a single blaOXA-48 gene was detected in the central and eastern regions (77%), while the bla NDM -gene was the predominant type in the northern region (27%). The southern regions showed the lowest percentages for harboring both blaOXA-48 and bla NDM genes (4%), while the western region isolates showed the highest percentage of harboring both genes (14%). CONCLUSION: The results illustrate the importance of molecular characterization of CRE isolates for patient care and infection prevention and control. Larger multicenter studies are needed to critically evaluate the risk factors and trends over time to understand the dynamics of spread and effective methods of control. LIMITATIONS: Lack of phenotypic susceptibility and clinical data. CONFLICT OF INTEREST: None.

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Computed tomography-guided transthoracic biopsy: Factors influencing diagnostic and complication rates

Cited by 11 publications

References 23 publications

Diagnostic Yield of Combined Pulmonary Cryobiopsies and Electromagnetic Navigation in Small Pulmonary Nodules

Diagnostic Yield of Combined Pulmonary Cryobiopsies and Electromagnetic Navigation in Small Pulmonary Nodules

Clinical value of contrast-enhanced ultrasound in transthoracic biopsy of malignant anterior mediastinal masses

Molecular characterization of carbapenem-resistant Enterobacterales in thirteen tertiary care hospitals in Saudi Arabia

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