Computed Tomography Guided Fine Needle Aspiration Cytology of Lung and Mediastinal Lesions

Gadodiya, Khushabu; Patil, Rekha Narendra; Kumbhalkar, Dinkar T; Raut, Waman K

doi:10.21276/ijcmr.2019.6.2.17

Cited by 5 publications

(10 citation statements)

References 8 publications

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“…In this study mean age of the patients was in concordance with study by Gangopadhyay et al, 4 Dharmaraj et al, 5 Ahmed et al, 6 Gupta et al, 7 Indiranarayan et al, 8 Saha et al, 9 Singh et al, 10 while it was contrary to study done by Mundal et al 11 and Mukherjee et al 12 In the present study there were 75 % male patients out of 100 patient. That result is similar to findings of Gangopadhyay et al, 4 Gadodiya et al 13 and Saha et al, 9 while in some studies 5,7,8 the preponderance is very high ie more than 80 % were male patients. In this study 61 % of males and 92 % of females were smokers.…”

Section: Discussionsupporting

confidence: 90%

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Of multidetector computed tomography (MDCT) in evaluation of lung nodule with histopathological correlation

Gupta¹,

Gupta²,

Chandra³

et al. 2021

Scripta Medica

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Background: Lung cancer is the most common and lethal cancer around the world. Computed tomography (CT) is an integral imaging technique for staging the lung cancer. Aim of this study was to correlate the multidetector CT (MDCT) findings of lung nodule with histopathological examination, as well as to assess the diagnostic accuracy of MDCT in evaluation of suspected lung nodule. Methods: One hundred patients with clinical or radiological suspicion of lung nodule referred for CT scan of thorax were included in the study. Histopathological analysis was performed. The location of the lesion was analysed and nodules were classified. Fine needle aspiration cytology (FNAC) was done with spinal needle under all aseptic precautions. The results obtained by MDCT were analysed and compared with histopathological findings done by CT guided FNAC. Results: Average age of patients was 65 years, 25 % were females and 75 % were males. Among all the patients 66 % of lesions were located in right side lung and 34 % of lesions were left in location. Of all, 2 % patients had lesions less than 3 cm, 11 % patients had lesion between 3-4 cm, 19 % patients had lesion between 4-5 cm, 26 % patients had lesion between 5-7 cm and 42 % patients had lesion greater than 7 cm. Many of these patients also presented with enlarged lymph nodes, most commonly mediastinal (73 %) followed by subcarinal (51 %), hilar (44 %) and supraclavicular (4 %) lymph nodes. The most common histological findings of lung nodules analysis were adenocarcinoma (41 %). Among the 100 patients 58 % had lesions located peripherally while 42 % had central lesions. CT was a highly sensitive (95.45 %) and moderately specific (75 %) test and also had a high positive predictive value (96 %) to diagnose malignant lung nodule. Conclusion: CT guided FNAC of lung nodule is a safe, minimal invasive procedure with a high diagnostic accuracy. The use of CT-guided FNAC in hilar and mediastinal nodules can avoid unnecessary exploratory surgery for staging and also diagnosis could be made with lesser cost.

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Section: Discussionsupporting

confidence: 90%

“…Similar findings were found in literature. 7,9,12,13 Patients with lung nodules also had various types of lymphadenopathy. Out of all patients 73 % patient had enlarged mediastinal lymph nodes, 51 % had subcarinal and 44 % had hilar lymph node involvement.…”

Section: Discussionmentioning

confidence: 99%

Of multidetector computed tomography (MDCT) in evaluation of lung nodule with histopathological correlation

Gupta¹,

Gupta²,

Chandra³

et al. 2021

Scripta Medica

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“…Introduced by Leyden in 1883 and Menbriel in 1986, the diagnostic lung puncture technique has long been used for the identification of infections and malignancy with high accuracy [1,9,10] . Following various advances in radiology, USG /CT guided FNAC of lung lesions is very helpful to arrive at a definitive diagnosis in infectious and neoplastic lesions though it is of utmost importance in diagnosis of malignancy [2,5,6,11] .…”

Section: Discussionmentioning

confidence: 99%

“…Patients present with a wide variety of symptoms which include cough, fever, shortness of breath, chest pain, loss of weight and haemoptysis. Rarely hoarseness of voice may also be observed [3,4,9] . In the present study in most common clinical symptom observed was breathlessness followed by fever and cough.…”

Section: Discussionmentioning

confidence: 99%

“…Various sampling techniques available include exfoliative and abrasive cytology, fine needle aspiration cytology (FNAC) and cell block preparations [3,4,5,6] . Ultrasound guided (USG) / Computerized tomography(CT) guided fine needle aspiration biopsy (FNAB) play a very important role in initial diagnosis [7,8,9] . FNAB in many cases proves to be the only diagnostic specimen available for definitive diagnosis, sub classification, including molecular studies and guiding therapeutic decisions in lung cancer.…”

Section: Introductionmentioning

confidence: 99%

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Fine needle aspiration cytology and correlation with biopsy in lung lesions

Shivamurthy¹,

Kudva²

2020

Int. J. Clin. Diagn. Pathol.

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Introduction: Lung cancer is one of the leading cause of death worldwide. High mortality makes early diagnosis and treatment of utmost importance. Cytology plays an important role in the initial evaluation and diagnosis of these patients. Currently various sampling techniques are available to procure specimens for cytologic evaluation, which include exfoliative, abrasive cytology and fine needle aspiration cytology (FNAC). The aim of the study is to assess the role of CT/USG guided FNAC of lung and pleural lesions and correlate the findings with biopsy Methods: 82 patients with lung lesions were evaluated with USG/CT guided FNA and biopsy between January 2016 & July 2016. The findings of FNAC were correlated with the biopsy wherever available, in order to assess the reliability of a cytologic diagnosis of the various lung lesions on FNAC. The various differential diagnosis are also discussed. Results: The age group ranged from 19-84ys with a median age of 60 yrs, and a male predominance (92.6%). Majority of lesions involved the lung parenchyma. Benign, suspicious and malignant lesions accounted for 8.5%, 3.7% and 87.8% respectively. On classification, adenocarcinomas accounted for majority of the malignant lesions (34.1%) followed by squamous cell carcinomas (26.8%). 57 out of 82 patients underwent biopsy of the lung lesions. When the FNAC findings were correlated with the histopathological biopsy findings, 6.7 % (4) of cases did not correlate. Thus the sensitivity and specificity of the study were 84.2% and 100% respectively. Preoperative diagnosis of lung cancer detected by screening with CT could be reliably made by FNAC. Difficulty in classification occurs in carcinomas of high nuclear grade with prominent nucleoli, including poorly differentiated squamous cell carcinoma and large cell neuroendocrine carcinoma. Differentiating adenocarcinoma and squamous cell carcinomas could also be challenging at times. Conclusion: CT guided FNAC has emerged as a less invasive, cost effective, rapid and fairly accurate diagnostic aid in the evaluation of lung lesions. Correlation of the cytomorphologic features with the clinical presentation of the patient including radiologic imaging are absolutely critical in the accurate interpretations of respiratory cytology specimens.

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Computed Tomography- Guided Fine Needle Aspiration Cytology of Lung Mass- A 5 Years Study in a Tertiary Health Care Centre

Konjengbam¹,

Haobijam²

2020

jebmh

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BACKGROUNDLung cancer is the major cause of cancer related deaths all over the world. Computed Tomography (CT) -Guided Fine Needle Aspiration Cytology (FNAC) of a lung mass is an effective modality to diagnose lung cancer. FNAC is a rapidly emerging diagnostic modality to assess the nature of radiologically demonstrated lung mass lesions. We wanted to study the usefulness of CT-Guided FNAC in the evaluation of cytopathological spectrum in lung lesions. METHODSA cross-sectional study was carried out in a total of 150 cases for a period of 5 years from November 2014 to November 2019 on cases of lung mass lesions with a strong clinical suspicion of pulmonary neoplasm. CT-Guided transthoracic FNAC was performed and cytology smears were stained with May-Grunwald-Giemsa (MGG) stain, conventional Papanicolaou (Pap) stain and Ziehl Neelsen (ZN) stain. Smears were examined under microscope and broadly categorized into unsatisfactory, tubercular, benign and malignant lesions. RESULTSA total of 150 cases of lung mass lesions were studied, of which 85 were males (78.4%). The mean age of the patients was 67 years. Maximum cases of benign lesions were chronic non-specific suppurative lesions (17.3%, 26 cases) followed by tuberculosis (3.3%, 05 cases). Regarding the malignant categories, adenocarcinoma (22.7%; 34 cases) was the most common malignancy followed by non-small cell carcinoma not otherwise specified (NOS) (14.7%; 22 cases), squamous cell carcinoma (8.0%, 12 cases) and small cell carcinoma (6.7%; 10 cases) respectively. CONCLUSIONSCT guided FNAC is a simple, less expensive, and reliable method for diagnosis of pulmonary lesions.

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Computed Tomography Guided Fine Needle Aspiration Cytology of Lung and Mediastinal Lesions

Cited by 5 publications

References 8 publications

Of multidetector computed tomography (MDCT) in evaluation of lung nodule with histopathological correlation

Of multidetector computed tomography (MDCT) in evaluation of lung nodule with histopathological correlation

Fine needle aspiration cytology and correlation with biopsy in lung lesions

Computed Tomography- Guided Fine Needle Aspiration Cytology of Lung Mass- A 5 Years Study in a Tertiary Health Care Centre

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