Computed tomography‐based tissue‐engineered scaffolds in craniomaxillofacial surgery

Smith, Miller H.; Flanagan, Colleen L.; Kemppainen, Jessica M.; Sack, Jayson A.; Chung, Haseung; Das, Suman; Hollister, Scott J.; Feinberg, S. E.

doi:10.1002/rcs.143

Cited by 109 publications

(58 citation statements)

References 59 publications

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“…Thus, by combining both the macroscopic and architecture image design databases, it is possible to design scaffolds with anatomic form and fixation, while having effective mechanical and mass-transport properties that are designed based on 3D topology arrangement of materials and pore structures in 3D space. Smith et al [45] used this approach to design a scaffold for mandibular condyle reconstruction in Yucatan minipigs, starting from CT scans of the minipigs mandible.…”

Section: Scaffold Designmentioning

confidence: 99%

Scaffold Design and Manufacturing: From Concept to Clinic

Hollister¹

2009

Advanced Materials

361

243

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Since Robert Langer and colleagues pioneered the concept of reconstructing tissue using cells transplanted on synthetic polymer matrices in the early 1990s, research in the field of tissue engineering and regenerative medicine has exploded. This is especially true in the development of new materials and structures that serve as scaffolds for tissue reconstruction. The basic tenet of the last two decades holds scaffolds as degradable materials providing temporary function while enhancing tissue regeneration through the delivery of biologics. Although a number of new scaffolding materials and structures have been developed in research laboratories, the application of such materials practice even has been extremely limited. This paper argues that better integration of all these factors is needed to bring scaffolds from "concept to clinic". It reviews current work in all these areas and suggests where future work and funding is needed.

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Section: Scaffold Designmentioning

confidence: 99%

Scaffold Design and Manufacturing: From Concept to Clinic

Hollister¹

2009

Advanced Materials

361

243

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“…This method is particularly useful for tissue engineering since it allows a very good reproducibility and the production of almost any kind of structure within the limitations of each technique used. Using this technique, it is possible to design a structure that mimics the natural structure to be replaced (Van Cleynenbreugel et al 2002;Hutchmacher & Cool 2007;Smith et al 2007). …”

Section: Scaffold Designsmentioning

confidence: 99%

Computer-aided design and finite-element modelling of biomaterial scaffolds for bone tissue engineering

Lacroix

Planell

Prendergast

2009

Phil. Trans. R. Soc. A.

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Scaffold biomaterials for tissue engineering can be produced in many different ways depending on the applications and the materials used. Most research into new biomaterials is based on an experimental trial-and-error approach that limits the possibility of making many variations to a single material and studying its interaction with its surroundings. Instead, computer simulation applied to tissue engineering can offer a more exhaustive approach to test and screen out biomaterials. In this paper, a review of the current approach in biomaterials designed through computer-aided design (CAD) and through finite-element modelling is given. First we review the approach used in tissue engineering in the development of scaffolds and the interactions existing between biomaterials, cells and mechanical stimuli. Then, scaffold fabrication through CAD is presented and characterization of existing scaffolds through computed images is reviewed. Several case studies of finite-element studies in tissue engineering show the usefulness of computer simulations in determining the mechanical environment of cells when seeded into a scaffold and the proper design of the geometry and stiffness of the scaffold. This creates a need for more advanced studies that include aspects of mechanobiology in tissue engineering in order to be able to predict over time the growth and differentiation of tissues within scaffolds. Finally, current perspectives indicate that more efforts need to be put into the development of such advanced studies, with the removal of technical limitations such as computer power and the inclusion of more accurate biological and genetic processes into the developed algorithms.

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“…Biomaterials considered for tissue engineering scaffold fabricated via SLS include polycaprolactone (PCL) [12,[19][20][21][22][23][24], polyetheretherketone (PEEK) [17], polylactide acid (PLA) [25] and poly(lacticco-glycolide) (PLG) [26]. As these materials may not stimulate sufficient bone ingrowth on their own, bioactive components can be added to enhance bone ingrowth, cell attachment, etc.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffolds

et al. 2012

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In this paper, the use of the Selective Laser Sintering (SLS) process for the generation of bone tissue engineering scaffolds from PCL and PCL/TCP is explored. Different scaffold designs are generated and are assessed from the point of view of manufacturability, porosity and mechanical performance. Large scaffold specimens are generated, with a preferred design, and are assessed through an in vivo study in a critical size bone defect in the sheep tibia with subsequent microscopic, histological and mechanical evaluation. Further explorations are performed to generate scaffolds with increasing TCP contents.Scaffold fabrication from PCL and PCL/TCP mixtures with up to 50 mass-% TCP is shown to be possible. With increasing macroporosity the stiffness of the scaffolds is seen to drop, however, the stiffness can be increased by minor geometrical changes, such as the addition of a cage around the scaffold. In the animal study the selected scaffold for implantation did not perform as well as the TCP control in terms of new bone formation and the resulting mechanical performance of the defect area. A possible cause for this is presented.

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Computed tomography‐based tissue‐engineered scaffolds in craniomaxillofacial surgery

Abstract: Computationally designed scaffolds can support masticatory function in a large animal model as well as both osseous and cartilage regeneration. Our group is continuing to evaluate multiple implant designs in both young and mature Yucatan minipig animals.

Cited by 109 publications

References 59 publications

Scaffold Design and Manufacturing: From Concept to Clinic

Scaffold Design and Manufacturing: From Concept to Clinic

Computer-aided design and finite-element modelling of biomaterial scaffolds for bone tissue engineering

Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffolds

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