Computed Tomography–Based Distribution of Involved Lymph Nodes in Patients with Upper Esophageal Cancer

Li, M.; Liu, Y.; Xu, Liang; Huang, Yong; Li, W.; J, Yu; Kong, Li

doi:10.3747/co.22.2365

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…In our study, the lymph node group with a probability of 10% or more (an empirical cutoff value) of being involved was recommended containing in the CTVn. [ 12 , 14 ] On the basis of on our findings, 94.4 % (84 of 89 patients) occured the LNM in subgroup II and/or subgroup III region. The anatomic distribution of the 151 LNs indicated that more than 95% of the metastatic LNs was located in the group II and III region.…”

Section: Resultsmentioning

confidence: 57%

“…[12, 14] On the basis of on our findings, 94.4 % (84 of 89 patients) occured the LNM in subgroup II and/or subgroup III region. The anatomic distribution of the 151 LNs indicated that more than 95% of the metastatic LNs was located in the group II and III region.…”

Section: Resultsmentioning

confidence: 82%

“…Features supporting a consideration for clinical metastasis included lymph nodes with a short-axis diameter greater than 10 mm; a lymph node with a short axis less than 10 mm combined with hoarseness or vocal cord paralysis; the presence of an infiltrative margin, necrosis, inhomogeneous enhancement; at locations uncommon for reactive nodes; fluorodeoxyglucose-avid (if used). [ 12 , 24 , 25 ]…”

Section: Methodsmentioning

confidence: 99%

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Identification of risk factors and the pattern of lower cervical lymph node metastasis in esophageal cancer: implications for radiotherapy target delineation

et al. 2017

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Radiotherapy remains the important therapeutic strategy for patients with esophageal cancer (EC). At present, there is no uniform opinion or standard care on the range of radiotherapy in the treatment of EC patients. This study aimed to investigate the risk factors associated with lower cervical lymph node metastasis (LNM) and to explore the distribution pattern of lower cervical metastatic lymph nodes. It could provide useful information regarding accurate target volume delineation for EC. We identified 239 patients who initial diagnosed with esophageal squamous cell carcinoma. The clinicopathological factors related to LNM were analyzed and the locations of the lower cervical metastatic lymph nodes were transferred onto computed tomography images. The lower cervical area was further divided into four subgroups areas. The results showed that the incidence of lower cervical LNM was 37.2 % (89 of 239) and 94.4 % (84 of 89 patients) patients had subgroup II and/or subgroup III region LNM. Of those patients, 151 nodes were considered to be clinical metastatic in the lower cervical region and 96% nodes were located in group II and group III. Based on the present study, prophylactic irradiating to lower cervical areas is recommended for patients with deeper tumor invasion, the mediastinal level 1, 2, and 4 station LNM and the more number of LNM. The atlas showed that, for the lower cervical area, the subgroup II and III region should be precisely covered in the target volume and the subgroup I and IV may be spared for minimizing the toxicity.

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Section: Resultsmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 82%

Section: Methodsmentioning

confidence: 99%

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Identification of risk factors and the pattern of lower cervical lymph node metastasis in esophageal cancer: implications for radiotherapy target delineation

et al. 2017

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“…Similarly, Li et al demonstrated that for cervical and upper thoracic lesions, the most common site of nodal metastasis is the neck (39.2% and 21.8%, respectively), and proposed that the supraclavicular lymph nodes should be included at the superior border of the target volume. 9 Guidelines from the US National Comprehensive Cancer Network recommend that for cervical EC, the supraclavicular nodes and even the higher echelon cervical nodes should be subjected to elective treatment. 10…”

Section: Introductionmentioning

confidence: 99%

Anatomic distribution of supraclavicular lymph node in patients with esophageal cancer

Xing

Luo

Wang

et al. 2016

OTT

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PurposeDefinitive chemoradiation therapy remains the standard of care for patients with localized esophageal carcinoma who choose nonsurgical management. However, there is no consensus regarding delineation of the nodal clinical target volume (CTVn), especially for lower cervical lymph nodes. This study aimed to map the location of metastatic supraclavicular lymph nodes in thoracic esophageal carcinoma patients with supraclavicular node involvement and generate an atlas to delineate the CTVn for elective nodal radiation of esophageal squamous cell carcinoma.Patients and methodsIn this study, the supraclavicular regional lymph node was further divided into four subgroups. The locations of the involved supraclavicular nodes for all patients were then transferred onto a template computed tomography (CT) image. A volume probability map was then generated with nodal volumes, and was displayed on the template CT to provide a visual impression of nodal frequencies and anatomic distribution.ResultsWe identified 154 supraclavicular nodal metastases based on CT image in 96 patients. Of these, 29.2% were located in group I region, 59.7% in group II region, 10.4% in group III region, and 0.7% in group IV region.ConclusionOn the basis of our study, we suggest that the appropriate radiation field of CTVn should include the group I and II regions and the CTVn exterior margin along the lateral side of the internal jugular vein may be suitable.

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“…Li et al reported that the shortest diameter for the diagnostic criterion of LNs in esophageal cancer could be <10 mm on CT (14). As for radiotherapy, a CTbased study suggested that regional LN groups should be electively included in the clinical target volume for precise radiation administration (15).…”

Section: Introductionmentioning

confidence: 99%

Modified method to improve the diagnostic efficiency of 18F-FDG PET/CT in regional lymph node metastasis of esophageal squamous cell carcinoma

Liao¹,

Wei²,

Zhang³

et al. 2021

Ann Transl Med

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Computed Tomography–Based Distribution of Involved Lymph Nodes in Patients with Upper Esophageal Cancer

Abstract: Background Delineating the nodal clinical target volume (ctvn) remains a challenging task in patients with cervical

Cited by 10 publications

References 20 publications

Identification of risk factors and the pattern of lower cervical lymph node metastasis in esophageal cancer: implications for radiotherapy target delineation

Identification of risk factors and the pattern of lower cervical lymph node metastasis in esophageal cancer: implications for radiotherapy target delineation

Anatomic distribution of supraclavicular lymph node in patients with esophageal cancer

Modified method to improve the diagnostic efficiency of 18F-FDG PET/CT in regional lymph node metastasis of esophageal squamous cell carcinoma

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