Computed tomography attenuation predicts the growth of pure ground-glass nodules

Eguchi, Takashi; Kondo, Ryoichi; Kawakami, Satoshi; Matsushita, Mina; Yoshizawa, Akihiko; Hara, Daisuke; Matsuoka, Shunichiro; Takeda, Teiji; Miura, Kentaro; Agatsuma, Hiroyuki; Sakaizawa, Takao; Tominaga, Yoshiaki; Saito, Gaku; Toishi, Masayuki; Hamanaka, Kazutoshi; Hashizume, Masahiro; Shiina, Takayuki; Amano, Jun; Koizumi, Tomonobu; Yoshida, Kazuo

doi:10.1016/j.lungcan.2014.03.009

Cited by 42 publications

(74 citation statements)

References 23 publications

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“…However, (which reflects the product of size and attenuation) rather than the size of pulmonary nodules (6). CT attenuation has also been used to assess growth of part-solid and nonsolid pulmonary nodules (36,37). Both overall attenuation and characteristics of the attenuation distribution within nodules have In such cases, measurements should be performed on the sections that display the largest overall nodule diameter and the largest diameter of the solid component, respectively, and these sections should be identified in the radiologic report (Fig 13).…”

Section: Ct Section Thicknessmentioning

confidence: 99%

Recommendations for Measuring Pulmonary Nodules at CT: A Statement from the Fleischner Society

Bankier¹,

MacMahon²,

Goo³

et al. 2017

Radiology

263

188

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These recommendations for measuring pulmonary nodules at computed tomography (CT) are a statement from the Fleischner Society and, as such, incorporate the opinions of a multidisciplinary international group of thoracic radiologists, pulmonologists, surgeons, pathologists, and other specialists. The recommendations address nodule size measurements at CT, which is a topic of importance, given that all available guidelines for nodule management are essentially based on nodule size or changes thereof. The recommendations are organized according to practical questions that commonly arise when nodules are measured in routine clinical practice and are, together with their answers, summarized in a table. The recommendations include technical requirements for accurate nodule measurement, directions on how to accurately measure the size of nodules at the workstation, and directions on how to report nodule size and changes in size. The recommendations are designed to provide practical advice based on the available evidence from the literature; however, areas of uncertainty are also discussed, and topics needing future research are highlighted. RSNA, 2017 Online supplemental material is available for this article.

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Section: Ct Section Thicknessmentioning

confidence: 99%

Recommendations for Measuring Pulmonary Nodules at CT: A Statement from the Fleischner Society

Bankier¹,

MacMahon²,

Goo³

et al. 2017

Radiology

263

188

View full text Add to dashboard Cite

show abstract

“…Eight of ten studies examined a sex ratio of patients, and the other two (13, 21) examined a sex ratio of nodules ( Table 1). The number of nodules was equal to the number of patients in two of the studies (14,18). In the study conducted by Kobayashi et al (20), the number of nodules is 120, which is about twice the number of patients.…”

Section: Subjectsmentioning

confidence: 99%

The Natural Growth of Subsolid Nodules Predicted by Quantitative Initial CT Features: A Systematic Review

Gao

Kong

et al. 2020

Front. Oncol.

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Background: The detection rate for pulmonary nodules, particularly subsolid nodules (SSNs), has been significantly improved. The purpose of this review is to summarize the relationship between quantitative features of initial CT imaging and the subsequent natural growth of SSNs to explore potential reasons for these findings. Methods: Relevant studies were collected from a literature search of PubMed, Embase, Web of Science, and Cochrane. Data extraction was performed on the patients' basic information, CT methods, and acquisition methods, including quantitative CT features, and statistical methods. Results: A total of 10 relevant articles were included in our review, which included 850 patients with 1,026 SSNs. Overall, the results were variable, and the key findings were as follows. Seven studies looked at the relationship between the diameter and growth of SSNs, showing that SSNs with larger diameters were associated with increased growth. An additional three studies which focused on the relationship between CT attenuation and the growth of SSNs showed that SSNs with a high CT attenuation were associated with increased growth. Conclusion: CT attenuation may be useful in predicting the natural growth of SSNs, and mean CT attenuation may be more useful in predicting the natural growth of pure ground glass nodules (GGNs) than part-solid GGNs. While evaluation by diameter did have some limitations, it demonstrates value in predicting the growth of SSNs.

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“…This is an already well known and extensively reported parameter [11, 16, 20, 22] together with initial lesion size [11, 12, 16, 20, 22, 23], which is fundamental for the current management guidelines. We feel that the failure to reproduce other previously reported predictors of progression is likely due to our study population characteristics and relatively small study size.…”

Section: Discussionmentioning

confidence: 99%

Subsolid pulmonary nodule morphology and associated patient characteristics in a routine clinical population

et al. 2016

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ObjectivesTo determine the presence and morphology of subsolid pulmonary nodules (SSNs) in a non-screening setting and relate them to clinical and patient characteristics.MethodsA total of 16,890 reports of clinically obtained chest CT (06/2011 to 11/2014, single-centre) were searched describing an SSN. Subjects with a visually confirmed SSN and at least two thin-slice CTs were included. Nodule volumes were measured. Progression was defined as volume increase exceeding the software interscan variation. Nodule morphology, location, and patient characteristics were evaluated.ResultsFifteen transient and 74 persistent SSNs were included (median follow-up 19.6 [8.3–36.8] months). Subjects with an SSN were slightly older than those without (62 vs. 58 years; p = 0.01), but no gender predilection was found. SSNs were mostly located in the upper lobes. Women showed significantly more often persistent lesions than men (94 % vs. 69 %; p = 0.002). Part-solid lesions were larger (1638 vs. 383 mm3; p < 0.001) and more often progressive (68 % vs. 38 %; p = 0.02), compared to pure ground-glass nodules. Progressive SSNs were rare under the age of 50 years. Logistic regression analysis did not identify additional nodule parameters of future progression, apart from part-solid nature.ConclusionsThis study confirms previously reported characteristics of SSNs and associated factors in a European, routine clinical population.Key Points• SSNs in women are significantly more often persistent compared to men.• SSN persistence is not associated with age or prior malignancy.• The majority of (persistent) SSNs are located in the upper lung lobes.• A part-solid nature is associated with future nodule growth.• Progressive solitary SSNs are rare under the age of 50 years.

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Computed tomography attenuation predicts the growth of pure ground-glass nodules

Cited by 42 publications

References 23 publications

Recommendations for Measuring Pulmonary Nodules at CT: A Statement from the Fleischner Society

Recommendations for Measuring Pulmonary Nodules at CT: A Statement from the Fleischner Society

The Natural Growth of Subsolid Nodules Predicted by Quantitative Initial CT Features: A Systematic Review

Subsolid pulmonary nodule morphology and associated patient characteristics in a routine clinical population

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