Computed tomography and magnetic resonance imaging evaluation of lymph node metastasis in early colorectal cancer

Choi, Joonsung; Oh, Soon Nam; Yeo, Dong-Myung; Kang, Won Kyung; Jung, Chan Kwon; Kim, Sang Woo; Park, Michael Yong

doi:10.3748/wjg.v21.i2.556

Cited by 35 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An important independent predictor is the number of invaded lymph nodes (LNs) (7)(8)(9). The accurate identification of metastatic LNs (LN+) contributes to pre-operative cancer staging and influences treatment selection in clinical practice such as endoscopic resection or surgery, preoperative neoadjuvant chemotherapy (10).…”

Section: Introductionmentioning

confidence: 99%

Contrast‑enhanced CT imaging for the assessment of lymph node status in patients with colorectal cancer

Miao

Chen

et al. 2020

Oncol Lett

View full text Add to dashboard Cite

The aim of the present study was to identify a novel strategy that predicts the metastatic status of lymph nodes (LNs) in patients diagnosed with colorectal cancer, using detailed characteristics of contrast-enhanced CT scan images. A total of 284 preoperative CT scans derived from patients diagnosed with colorectal cancer at Second Affiliated Hospital, Zhejiang University School of Medicine between January 2013 and July 2018 were retrospectively reviewed. A total of 794 LNs were assessed for size, margins, morphology and subtle internal enhancements in the equilibrium phase. Imaging features were analyzed by two abdominal radiologists

show abstract

Section: Introductionmentioning

confidence: 99%

Contrast‑enhanced CT imaging for the assessment of lymph node status in patients with colorectal cancer

Miao

Chen

et al. 2020

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…Currently, no intraoperative imaging technique allows the detection of metastatic LNs during surgery performed for the resection of limited intraabdominal metastatic disease of colorectal origin such as peritoneal carcinomatosis (PC), and/or retroperitoneal LN metastases. In fact, planned surgery is essentially based on preoperative morphologic and/ or metabolic imaging [1,2].…”

Section: Introductionmentioning

confidence: 99%

Ex vivo detection of tumoral lymph nodes of colorectal origin with fluorescence imaging after intraoperative intravenous injection of indocyanine green

Liberale

Galdón

Moreau

et al. 2016

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…In a previous trial using both CT and MRI regarding lymph node metastases in early colorectal cancer with submucosal invasion, a sensitivity of 79% and specificity of 75% were achieved when using size criteria for metastasis of 4.1 mm in short diameter of the lymph node. The authors point out to pay more attention to small nodes in early cancer because it is more likely to be malignant than reactive as in more advanced cancers [20].…”

Section: Discussionmentioning

confidence: 99%

Morphological predictors for lymph node metastases on computed tomography in colon cancer

et al. 2019

View full text Add to dashboard Cite

Introduction/Background The aim of the study was to assess morphological predictors for lymph node metastases (Stage III disease) in colon cancer on computed tomography. Methods and materials Ninety-four patients with histology-proven colon cancer (adenocarcinoma) who underwent elective primary curative resection between the years 2012 and 2014 were included. Contrast-enhanced CT examinations were independently reviewed by two blinded observers regarding tumor location, depth of tumor invasion, and presence of lymph node metastases. Ocular presence of internal heterogeneity and presence of irregular outer border were used as morphological criteria for lymph node involvement. Protocol-based histopathology after curative surgery served as reference standard. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values, and accuracy for each morphological criterion for prediction of stage III disease were calculated. Inter-observer agreement was compared using Kappa statistics. Results According to histopathology, 59 patients were staged as I-II disease and 35 patients were staged as stage III disease. The presence of internal heterogeneity in a lymph node on CT resulted in moderate sensitivity (66-77%) but high specificity (95-95%) for prediction of Stage III disease by both observers. The presence of irregular outer border also resulted in poor sensitivity (49-54%) but high specificity (97-97%). The combination of either internal heterogeneity and/or irregular outer border per patient resulted in a moderate sensitivity (67-77%) and high specificity (95-95%), PPV (89-96%), and NPV (84-88%). Inter-observer agreement (Cohens Kappa) was 0.72. Consensus reading for the combined criteria resulted in sensitivity and specificity of 69% and 100%, respectively. Conclusion Using morphological criteria for lymph node metastases on CT examination in patients with colon cancer results in high specificity but moderate sensitivity in predicting stage III disease.

show abstract

Computed tomography and magnetic resonance imaging evaluation of lymph node metastasis in early colorectal cancer

Abstract: The short diameter size criterion of ≥ 4.1 mm for metastatic lymph nodes was optimal for nodal staging in early colorectal cancer.

Cited by 35 publications

References 25 publications

Contrast‑enhanced CT imaging for the assessment of lymph node status in patients with colorectal cancer

Contrast‑enhanced CT imaging for the assessment of lymph node status in patients with colorectal cancer

Ex vivo detection of tumoral lymph nodes of colorectal origin with fluorescence imaging after intraoperative intravenous injection of indocyanine green

Morphological predictors for lymph node metastases on computed tomography in colon cancer

Contact Info

Product

Resources

About