“…Pigmented orthochromatic leukodystrophy (POLD), another variant of adult onset leukodystrophy, was defined by the presence of pigmented macrophages, myelin and axonal loss. Patients, with adult onset leukodystrophies, have presented with variable behavioral, cognitive and motor changes (1,8,9,16,17,22,26,27). There is considerable overlap in the morphologic findings of the published cases of HDLS and POLD (17,18).…”