Computed Tomography and Magnetic Resonance Imaging of Adult Renal Cell Carcinoma Associated With Xp11.2 Translocation

Dang, Trien T.; Ziv, Etay; Weinstein, Stefanie; Meng, Maxwell V.; Wang, Zhen; Coakley, Fergus V.

doi:10.1097/rct.0b013e3182680182

Cited by 16 publications

(16 citation statements)

References 21 publications

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“…The clinical pictures of Xp11.2 RCC described above were generally consistent with our findings. Additionally, CT and MR features of this rare disease had also been described [27][28][29], and we found that Xp11.2 RCCs showed large, well-defined and cystic-solid masses, often containing hemorrhage and circular calcifications on the CT, with hetero geneous, moderately prolonged enhancement after intravenous injection of contrast media [30].…”

Section: Resultsmentioning

confidence: 73%

Renal Cell Carcinoma Associated with Xp11.2 Translocation/ TFE3 gene fusions: clinical experience and literature review

Chen

Gan

et al. 2015

Future Oncol.

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Section: Resultsmentioning

confidence: 73%

Renal Cell Carcinoma Associated with Xp11.2 Translocation/ TFE3 gene fusions: clinical experience and literature review

Chen

Gan

et al. 2015

Future Oncol.

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“…However, due to the rarity of XP11.2 translocation RCC, only a few case reports focusing on its imaging features are available [11], [13]–[17]. MRI is suggested to be superior to CT due to the increased soft-tissue contrast and multiple imaging weights of MRI, which better reveal the heterogeneous composition (such as hemorrhage or necrosis) of this type of tumor [18].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging and Computed Tomography Characteristics of Renal Cell Carcinoma Associated with Xp11.2 Translocation/TFE3 Gene Fusion

Wang

Ding

et al. 2014

PLoS ONE

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PurposeTo characterize Xp11.2 translocation renal cell carcinoma (RCC) using magnetic resonance imaging (MRI) and computed tomography (CT).MethodsThis study retrospectively collected the MRI and CT data of twelve patients with Xp11.2 translocation RCC confirmed by pathology. Nine cases underwent dynamic contrast-enhanced MRI (DCE-MRI) and 6 cases underwent CT, of which 3 cases underwent MRI and CT simultaneously. The MRI and CT findings were analyzed in regard to tumor position, size, hemorrhagic, cystic or necrotic components, calcification, tumor density, signal intensity and enhancement features.ResultsThe age of the 12 patients ranged from 13 to 46 years (mean age: 23 years). T2WI revealed heterogeneous intensity, hyper-intensity, and slight hypo-intensity in 6 cases, 2 cases, and 1 case, respectively. On DCE-MR images, mild, moderate, and marked rim enhancement of the tumor in the corticomedullary phase (CMP) were observed in 1, 6, and 2 cases, respectively. The tumor parenchyma showed iso-attenuation (n = 4) or slight hyper-attenuation (n = 1) compared to the normal renal cortex on non-contrast CT images. Imaging findings were suggestive of hemorrhage (n = 4) or necrosis (n = 8) in the tumors, and there was evidence of calcification in 8 cases by CT (n = 3) and pathology (n = 8). On dynamic contrast-enhanced CT images, 3 cases and 1 case manifested moderate and strong CMP enhancement, respectively. Nine tumors by MRI and 4 tumors by CT showed prolonged enhancement. Three neoplasms presented at stage I, 2 at stage II, 3 at stage III, and 4 at stage IV according the 2010 AJCC staging criteria.ConclusionsXP11.2 translocation RCC should be considered when a child or young adult patient presents with a renal tumor with heterogeneous features such as hemorrhage, necrosis, cystic changes, and calcification on CT and MRI and/or is accompanied by metastatic evidence.

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“…Compared with other RCCs, its clinical process is more invasive with a poorer prognosis (10). Furthermore, the imaging manifestations of Xp11.2 translocation RCC are diverse, including hemorrhage, necrosis, cystic degeneration and calcification (8,(11)(12)(13)(14)(15). Therefore, the pre-operative diagnosis of this entity is occasionally difficult, as in the present case.…”

Section: Discussionmentioning

confidence: 69%

Xp11.2 translocation renal cell carcinoma with egg-shell calcification mimicking a benign renal tumour: A case report

Liang

2015

Oncology Letters

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Abstract. The present study reports the case of a 20-year-old female who was identified to have a left renal angiomyolipoma (AML) with hemorrhage. Following temporary conservative observation, the patient received continuous ultrasonic follow-up. Due to the rapid growth of the lesion, further examinations were performed. Computed tomography (CT) plain scans revealed a partly high-density mass with marginal egg-shell calcification. Enhanced CT revealed a solid tumor with a rich blood supply. Since no fats were detected, the possibility of a typical AML was excluded, but the diagnoses of epithelioid AML or renal cancer were considered. Finally, the left kidney was partially excised laparoscopically. The intraoperative frozen section indicated a diagnosis of renal cell carcinoma (RCC). The left kidney was subsequently radically excised. . Routine histopathological and immunohistochemical tests confirmed that the lesion was an RCC with an Xp11.2 translocation. The present study introduces the pitfalls in the diagnosis of Xp11.2 translocation RCC, which is a rare RCC subtype accompanied with uncommon imaging manifestations. The study suggests that when a rapidly-growing AML is detected by ultrasound, renal cancer with marginal calcification should be considered. Moreover, although egg-shell calcification mostly occurs in benign renal lesions, further examinations, such as enhanced CT, are recommended for identifying the nature of the masses and excluding the possibility of malignant tumors.

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Computed Tomography and Magnetic Resonance Imaging of Adult Renal Cell Carcinoma Associated With Xp11.2 Translocation

Abstract: The possibility of renal cell carcinoma associated with Xp11.2 translocation should be considered for a renal mass seen in a patient 45 years or younger, which demonstrates hemorrhage or necrosis or advanced stage disease at CT or MRI.

Cited by 16 publications

References 21 publications

Renal Cell Carcinoma Associated with Xp11.2 Translocation/ TFE3 gene fusions: clinical experience and literature review

Renal Cell Carcinoma Associated with Xp11.2 Translocation/ TFE3 gene fusions: clinical experience and literature review

Magnetic Resonance Imaging and Computed Tomography Characteristics of Renal Cell Carcinoma Associated with Xp11.2 Translocation/TFE3 Gene Fusion

Xp11.2 translocation renal cell carcinoma with egg-shell calcification mimicking a benign renal tumour: A case report

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