Computed tomographic mammography (CTM)

Gisvold, JJ; Reese, David F.; Karsell, PR

doi:10.2214/ajr.133.6.1143

Cited by 42 publications

(19 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 However, little progress was made due to the limitation of image quality and the exposure of the x-ray radiation dose. Although computed tomographic mam-mography ͑CTM͒ was studied in the late 1970s, [8][9][10] this modality was has been largely dismissed due to concerns about radiation dose and cost effectiveness. We and other investigators have been studying the feasibility of using a pendant geometry cone beam CT ͑CBCT͒ scanner for breast cancer imaging.…”

Section: Introductionmentioning

confidence: 99%

Dual resolution cone beam breast CT: A feasibility study

et al. 2009

View full text Add to dashboard Cite

Purpose: In this study, the authors investigated the feasibility of a dual resolution volume-ofinterest ͑VOI͒ cone beam breast CT technique and compared two implementation approaches in terms of dose saving and scatter reduction. Methods: With this technique, a lead VOI mask with an opening is inserted between the x-ray source and the breast to deliver x-ray exposure to the VOI while blocking x rays outside the VOI. A CCD detector is used to collect the high resolution projection data of the VOI. Low resolution cone beam CT ͑CBCT͒ images of the entire breast, acquired with a flat panel ͑FP͒ detector, were used to calculate the projection data outside the VOI with the ray-tracing reprojection method. The Feldkamp-Davis-Kress filtered backprojection algorithm was used to reconstruct the dual resolution 3D images. Breast phantoms with 180 m and smaller microcalcifications ͑MCs͒ were imaged with both FP and FP-CCD dual resolution CBCT systems, respectively. Two approaches of implementing the dual resolution technique, breast-centered approach and VOI-centered approach, were investigated and evaluated for dose saving and scatter reduction with Monte Carlo simulation using a GEANT4 package. Results:The results showed that the breast-centered approach saved more breast absorbed dose than did VOI-centered approach with similar scatter reduction. The MCs in fatty breast phantom, which were invisible with FP CBCT scan, became visible with the FP-CCD dual resolution CBCT scan. Conclusions:These results indicate potential improvement of the image quality inside the VOI with reduced breast dose both inside and outside the VOI.

show abstract

Section: Introductionmentioning

confidence: 99%

Dual resolution cone beam breast CT: A feasibility study

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Cone-beam CT, on the other hand, can provide true 3D breast images with isotropic resolution (145 μm or smaller) and radiation dose comparable to two-view mammography [2]. Conventional fan-beam CT applied to breast cancer imaging in the 1970s suffered from limitations including high patient dose, low spatial resolution, long scanning time, large slice thickness, and cardiac and respiratory motion [3,4]. The advantages of cone-beam CT include a flatpanel digital detector, true 3D images with isotropic resolution, reduced motion artifacts, breast-only exposure to radiation, greater efficiency in use of the X-ray beam, no overlapping structures in the breast, and high contrast resolution.…”

Section: Introductionmentioning

confidence: 99%

Dedicated Cone-Beam Breast CT: Feasibility Study with Surgical Mastectomy Specimens

Yang

Çarkaci

Chen

et al. 2007

American Journal of Roentgenology

View full text Add to dashboard Cite

OBJECTIVE-The purpose of this study was to investigate the feasibility of diagnostic breast imaging using a flat-panel detector-based cone-beam CT system. CONCLUSION-Imaging of 12 mastectomy specimens was performed at 50-80 kVp with a voxel size of 145 or 290 μm. Our study shows that cone-beam breast CT images have exceptional tissue contrast and can potentially reduce examination time with comparable radiation dose.Keywords breast neoplasm; CT radiography; mastectomy; radiation dose; specimen radiography Mammography is an important tool for the screening, diagnosis, and management of breast cancers. The effectiveness of mammography is compromised by fundamental problems including radiation scatter, noise, and the over-lapping of cancers with breast anatomy. Tomosynthesis may partially overcome this limitation, but its image quality suffers from crude depth resolution and associated artifacts [1]. Cone-beam CT, on the other hand, can provide true 3D breast images with isotropic resolution (145 μm or smaller) and radiation dose comparable to two-view mammography [2]. Conventional fan-beam CT applied to breast cancer imaging in the 1970s suffered from limitations including high patient dose, low spatial resolution, long scanning time, large slice thickness, and cardiac and respiratory motion [3,4]. The advantages of cone-beam CT include a flatpanel digital detector, true 3D images with isotropic resolution, reduced motion artifacts, breast-only exposure to radiation, greater efficiency in use of the X-ray beam, no overlapping structures in the breast, and high contrast resolution. We constructed a flat-panel detector-based cone-beam CT system to investigate the feasibility for dedicated breast imaging [5]. Materials and MethodsThe experimental system consists of a general radiography tube pointing at a 30 × 40 cm amorphous silicon (a-Si/CsI) flat-panel digital detector (Paxscan 4030CB, Varian Medical Systems). A motor-driven rotation stage is used to position and rotate the specimen to simulate dedicated breast CT in which the patient would lie on a table in the prone position with one breast drawn downward through an opening to allow the X-ray tube and detector to rotate around and scan the breast beneath the table (Fig. 1).A total of 12 mastectomy specimens were acquired fresh from the pathology laboratory in our institution with institutional review board approval. Each specimen was placed in a receptacle formulated from an inverted soda bottle, and the holder was placed on the rotation stage. Scanning was performed at 50-80 kVp with reconstructed voxel size of 145 or 290 μm. The exposures in air at the isocenter of the cone-beam CT system were measured with a pencil-probe ion chamber, resulting in calculated dose levels equivalent to 6-24 mGy for the breast, which correspond to 1-4 times the mean glandular dose limits for two-view mammograms of a 5-cm-thick compressed breast. ResultsThe mean scanning time was 12 seconds for low-resolution (binning) mode, which was adequate for visualizing tissue struc...

show abstract

“…A dedicated fan beam CT mammography imaging scanner for research was previously constructed by GE (GE Medical System, Milwaukee, Wisconsin) in the 1970s and clinical trials on the system were performed [8][9]. Due to then-immature CT technology, long scanning time, relatively low spatial resolution, suboptimal detector and x-ray technique used, it was not conclusive from the results of those studies if fan beam CT mammography of that time was superior to the then-conventional mammography of that time [8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Due to then-immature CT technology, long scanning time, relatively low spatial resolution, suboptimal detector and x-ray technique used, it was not conclusive from the results of those studies if fan beam CT mammography of that time was superior to the then-conventional mammography of that time [8][9].…”

Section: Introductionmentioning

confidence: 99%

Flat-panel detector-based cone-beam volume CT breast imaging: preliminary phantom study

Ning

Chen

Conover

et al. 2001

Medical Imaging 2001: Physics of Medical Imaging

View full text Add to dashboard Cite

The clinical goal of breast imaging is to detect tumor masses when they are as small as possible, preferably less than 10 mm in diameter. Conventional film-screen mammography is the most effective tool for the early detection of breast cancer currently available. However, conventional mammography has relatively low sensitivity to detect small breast cancers (under several millimeters). Specificity and the positive predictive value of mammography remain limited owing to an overlap in the appearance of benign and malignant lesions, and surrounding structure. The limitations accompanying conventional mammography is to be addressed by incorporating a cone beam volume CT reconstruction technique with a recently developed flat panel detector. A computer simulation study has been performed to prove the feasibility of developing a flat panel detector-based cone beam volume CT breast imaging (FPD-CBVCTBI) technique. In this study, a preliminary phantom experiment is conducted to verify the findings in the computer simulation using a prototype flat panel detectorbased cone beam volume CT scanner. The results indicate that the FPD-CBVCTBI technique effectively removes structure overlap and significantly improves the detectability of small breast tumors. This suggests that FPD-CBVCTBI is a potentially powerful breast-imaging tool.

show abstract

Computed tomographic mammography (CTM)

Cited by 42 publications

References 7 publications

Dual resolution cone beam breast CT: A feasibility study

Dual resolution cone beam breast CT: A feasibility study

Dedicated Cone-Beam Breast CT: Feasibility Study with Surgical Mastectomy Specimens

Flat-panel detector-based cone-beam volume CT breast imaging: preliminary phantom study

Contact Info

Product

Resources

About