Computed tomographic colonography in the diagnosis of colorectal cancer

Sabanli, M; Balasingam, Adrian; Bailey, W; Eglinton, Timothy; Hider, Phil; Frizelle, Frank

doi:10.1002/bjs.7098

Cited by 26 publications

(23 citation statements)

References 17 publications

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“…This has been established by a number of studies 22,23 . Although only 70·2 per cent of the study population underwent subsequent colonic evaluation by either CT colonography or colonoscopy, the effect of incomplete follow-up was minimized by cross-checking the national cancer registry for colorectal cancer diagnoses.…”

Section: Discussionmentioning

confidence: 99%

Routine colonoscopy following acute uncomplicated diverticulitis

Westwood

Eglinton

Frizelle

2011

British Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Routine colonoscopy following acute uncomplicated diverticulitis

Westwood

Eglinton

Frizelle

2011

British Journal of Surgery

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“…The sensitivity of CT colonography for the detection of CRC is approximately 95% which compares very favorably with that of barium enema (94%) and optical colonoscopy (92%) [7]. PET-CT colonography, while being an intriguing prospect, may have too great a radiation load for a screening study but may yet prove appropriate for selected indications [8].…”

Section: Pet-ct For the Initial Diagnosis Of Crcmentioning

confidence: 99%

The Use of PET-CT in the Assessment of Patients with Colorectal Carcinoma

O’Connor

McDermott

Slattery

et al. 2011

International Journal of Surgical Oncology

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Colorectal cancer is the third most commonly diagnosed cancer, accounting for 53,219 deaths in 2007 and an estimated 146,970 new cases in the USA during 2009. The combination of FDG PET and CT has proven to be of great benefit for the assessment of colorectal cancer. This is most evident in the detection of occult metastases, particularly intra- or extrahepatic sites of disease, that would preclude a curative procedure or in the detection of local recurrence. FDG PET is generally not used for the diagnosis of colorectal cancer although there are circumstances where PET-CT may make the initial diagnosis, particularly with its more widespread use. In addition, precancerous adenomatous polyps can also be detected incidentally on whole-body images performed for other indications; sensitivity increases with increasing polyp size. False-negative FDG PET findings have been reported with mucinous adenocarcinoma, and false-positive findings have been reported due to inflammatory conditions such as diverticulitis, colitis, and postoperative scarring. Therefore, detailed evaluation of the CT component of a PET/CT exam, including assessment of the entire colon, is essential.

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“…However, reports in the clinical literature commonly diminish its value due to the facts that it is not as accurate as colonoscopy and cannot perform biopsy . Also like double‐contrast BE, CT colonography has been included in the screening guidelines, but it has not been widely used for colon cancer screening . On the other hand, the FOBT is a simple and cheap test, but it has less than ideal clinical specificity .…”

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A plasma microRNA panel for early detection of colorectal cancer

et al. 2014

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Colonoscopy remains the standard screening method for detecting colorectal cancer (CRC) at an early stage. However, many people avoid having a colonoscopy because of the fear for its potential complications. Our study aimed to identify plasma microRNAs for preliminarily screening CRC in general population, so that some unnecessary colonoscopies can be avoided. We investigated plasma microRNA expression in three independent cohorts including the discovery (n 5 80), training (n 5 112), and validation (n 5 49) phases recruited at two medical centers. Microarrays were used for screening 723 microRNAs in 80 plasma samples to identify candidate microRNAs. Quantitative reverse-transcriptase PCR was performed on the 161 training and validation plasma samples to evaluate the candidate microRNAs discovered from microarrays. A logistic regression model was constructed based on the training cohort and then verified by using the validation dataset. Area under the receiver operating characteristic curve (AUC) was used to evaluate the diagnostic accuracy. We identified a panel of miR-409-3p, miR-7, and miR-93 that yielded high diagnostic accuracy in discriminating CRC from healthy group (AUC: 0.866 and 0.897 for training and validation dataset, respectively). Moreover, the diagnostic performance of the microRNA panel persisted in nonmetastasis CRC stages (Dukes' A-B, AUC: 0.809 and 0.892 for training and validation dataset, respectively) and in metastasis CRC stages (Dukes' C-D, AUC: 0.917 and 0.865 for training and validation dataset, respectively). In conclusion, our study reveals a plasma microRNA panel that has potential clinical value in early CRC detection and would play a critical role on preliminarily screening CRC in general population.

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Computed tomographic colonography in the diagnosis of colorectal cancer

Abstract: The sensitivity of 95 per cent for CTC in the diagnosis of colorectal cancer compares favourably with that of double-contrast barium enema (92 per cent) and colonoscopy (94 per cent).

Cited by 26 publications

References 17 publications

Routine colonoscopy following acute uncomplicated diverticulitis

Routine colonoscopy following acute uncomplicated diverticulitis

The Use of PET-CT in the Assessment of Patients with Colorectal Carcinoma

A plasma microRNA panel for early detection of colorectal cancer

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