Computationally Guided DIW Technology to Enable Robust Printing of Inks with Evolving Rheological Properties (Adv. Mater. Technol. 3/2023)

López-Donaire, María Luisa; Aranda‐Izuzquiza, Gonzalo de; Garzon-Hernandez, S.; Crespo-Miguel, J.; Torre, Miguel Fernandez‐de la; Velasco, Diego; Garcia‐Gonzalez, Daniel

doi:10.1002/admt.202370012

Cited by 2 publications

(3 citation statements)

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“…Previously, the opacity of the magnetic particles constrained the use of the system to upright fluorescence microscopes. Here, we implement our recently developed direct ink writing (DIW) printer [ 26 ] to design multicompartment active substrates that can transmit different heterogeneous forces to an inner magnetically inert region (Figure 2). The absence of magnetic particles in the internal region makes it transparent to allow the integration of the device with different imaging systems without compromising the force transmission (Figure , Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

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Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto‐Active Substrates

Gomez‐Cruz,

Fernandez‐de la Torre,

Lachowski

et al. 2024

Advanced Materials

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This work introduces NeoMag, a system designed to enhance cell mechanics assays in substrate deformation studies. NeoMag uses multidomain magneto‐active materials to mechanically actuate the substrate, transmitting reversible mechanical cues to cells. The system boasts full flexibility in alternating loading substrate deformation modes, seamlessly adapting to both upright and inverted microscopes. The multidomain substrates facilitate mechanobiology assays on 2D and 3D cultures. The integration of the system with nanoindenters allows for precise evaluation of cellular mechanical properties under varying substrate deformation modes. The system was used to study the impact of substrate deformation on astrocytes, simulating mechanical conditions akin to traumatic brain injury and ischemic stroke. The results reveal local heterogeneous changes in astrocyte stiffness, influenced by the orientation of subcellular regions relative to substrate strain. These stiffness variations, exceeding 50% in stiffening and softening, and local deformations significantly alter calcium dynamics. Furthermore, sustained deformations induce actin network reorganisation and activate Piezo1 channels, leading to an initial increase followed by a long‐term inhibition of calcium events. Conversely, fast and dynamic deformations transiently activate Piezo1 channels and disrupt the actin network, causing long‐term cell softening. These findings unveil mechanical and functional alterations in astrocytes during substrate deformation, illustrating the multiple opportunities this technology offers.

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Section: Resultsmentioning

confidence: 99%

“…The resulting inks were loaded into two syringes equipped in the in‐house 3D printer. [ 26 ] This technology allows for printing multicompartment MREs using time‐varying functional materials. MRE cylinders 20 mm in diameter and 4mm in height were printed, incorporating an inner hole of 8 mm in diameter with PDMS without particles.…”

Section: Methodsmentioning

confidence: 99%

Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto‐Active Substrates

Gomez‐Cruz,

Fernandez‐de la Torre,

Lachowski

et al. 2024

Advanced Materials

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“…[ 12–16 ] The multi‐material approach brings magnetorheological elastomers to the engineering application of multi‐functional mechanical sensor or actuator as a response to multiple physical stimuli. [ 17,18 ] Composites designed by inserting permanent magnets into a 2D elastic network (a mass‐spring representation of elastomeric materials) [ 19–22 ] offer potential to enhance protective materials performance by limiting stress‐transfer through the medium. [ 23 ] In a related context, wave propagation in such magneto‐elastic lattices has been widely studied to understand acoustic bandgaps and cloaking capabilities.…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembled Robust 2D Networks from Magneto‐Elastic Bars

Yang

Leng

Sun

et al. 2023

Adv Materials Technologies

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Magneto‐elastic materials facilitate features such as shape programmability, adaptive stiffness, and tunable strength, which are critical for advances in structural and robotic materials. Magneto‐elastic networks are commonly fabricated by employing hard magnets embedded in soft matrices to constitute a monolithic body. These architected network materials have excellent mechanical properties but damage incurred in extreme loading scenarios are permanent. To overcome this limitation, we present a novel design for elastic bars with permanent fixed dipole magnets at their ends and demonstrate their ability to self‐assemble into magneto‐elastic networks under random vibrations. The magneto‐elastic unit configuration, most notably the orientation of end dipoles, is shown to dictate the self‐assembled network topology, which can range from quasi‐ordered triangular lattices to stacks or strings of particles. Network mechanics are probed with uniaxial tensile tests and design criteria for forming stable lightweight 2D networks are established. It is shown that these magneto‐elastic networks rearrange and break gracefully at their magnetic nodes under large excitations and yet recover their original structure at moderate random excitations. This work paves the way for structural materials that can be self‐assembled and repaired on‐the‐fly with random vibrations, and broadens the applications of magneto‐elastic soft materials.

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Computationally Guided DIW Technology to Enable Robust Printing of Inks with Evolving Rheological Properties (Adv. Mater. Technol. 3/2023)

Cited by 2 publications

References 0 publications

Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto‐Active Substrates

Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto‐Active Substrates

Self‐Assembled Robust 2D Networks from Magneto‐Elastic Bars

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