Computationally expanding infinium HumanMethylation450 BeadChip array data to reveal distinct DNA methylation patterns of rheumatoid arthritis

Fan, Shicai; Li, Chengzhe; Ai, Rizi; Wang, Mengchi; Firestein, Gary S.; Wang, Wei

doi:10.1093/bioinformatics/btw089

Cited by 26 publications

(31 citation statements)

References 39 publications

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“…Methylation levels of cg23700278, cg27427581, cg04334751, cg26764200 are found increased significantly after MTX treatment (Nair et al, 2019). In addition, DNA methylation of LBH, CASP8, OLIG3, IRF5, HLA-G, ELMO1, TRHDE, SLCO1C1, PLD4, AIRE and HLA-DQA1 are demonstrated involved in pathogenesis of RA and then are recommended as promising therapeutic markers (Fan et al, 2016). AZU1, LTBR, RTEL1 are hypomethylated and related to the trigger of autoimmune signaling cascade indicating the potential roles as epigenetic susceptibility markers (Wang et al, 2018).…”

Section: Dna Methylation Mediated Disease Risk Disease Activity and mentioning

confidence: 97%

Epigenetic Regulation Mediated by Methylation in the Pathogenesis and Precision Medicine of Rheumatoid Arthritis

Guo

Chang

et al. 2020

Preprint

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Rheumatoid arthritis (RA) as a complex disease is thought triggered by interaction between genetics and environment, especially the shared epitope (SE) and cell surface calreticulin (CSC) theory. However, all the evidence shows genetic diversity and environment exposure cannot explain all the clinical characteristics heterogeneity of rheumatoid arthritis. In contrast, recent studies demonstrate that epigenetics play important roles in the pathogenesis of rheumatoid arthritis, especially DNA methylation and histone modification. DNA methylation and histone methylation are involved in innate and adoptive immune cell differentiation and the migration, proliferation, apoptosis, and mesenchymal characteristics of fibroblast-like synoviocytes (FLS). Epigenetic mediated regulation to immune genes and inflammation pathway provides well explanation to dynamic expression network of rheumatoid arthritis. In this review, we summarized the comprehensive evidence to show methylation modification occurred in DNA and histone are significantly involved in the pathogenesis of rheumatoid arthritis and could be applied as the promising biomarker in the disease activity and drug response prediction. We also explained the opportunity and challenge of the current epigenetics research in rheumatoid arthritis. In summary, epigenetic modules provide possible interface through which genetic and environmental risk factors connect together to contribute to the susceptibility and pathogenesis of RA. Meanwhile epigenetic regulators provided promising drug targets to develop novel therapeutic drugs for rheumatoid arthritis. Finally, DNA methylation and histone modification will be important features to provide better rheumatoid arthritis subtype identification to accelerate personalized treatment and precision medicine.

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Section: Dna Methylation Mediated Disease Risk Disease Activity and mentioning

confidence: 97%

Epigenetic Regulation Mediated by Methylation in the Pathogenesis and Precision Medicine of Rheumatoid Arthritis

Guo

Chang

et al. 2020

Preprint

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“…Tyrosinase acts as an enzyme meant to control melanogenesis. With the widespread presence of melanoma, it is seen that there is an overexpression of tyrosinase [33][34][35][36][37][38][39][40] . This has led to the growth of dopamine which in turn produces dopamine quinone and dopaquinone 5 .…”

Section: Inhibitors For Melanomamentioning

confidence: 99%

Role of Inhibitors in Controlling the Diseases

Zhu¹

2019

J. Drug Delivery Ther.

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Inhibitors are those particular molecules that have unique properties to control the function of a disease-causing agent. The review sheet discusses the list of inhibitors for every disease and the ideal mechanism to excite the same for a better application and impact. Most of the inhibitors in this report are noncompetitive which means that they can survive and give an efficient result to the disease on its own without the need for an external inhibitor. Keywords: Inhibitors, disease-causing agent, enzymes activity

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“…The process of antipsychotic delivery is not researched in depth. However, nanoparticle-based administration to the treatment of psychotic problems tends to enhance the life of the affected individual and prove biocompatibility [33][34][35][36][37][38] For the brain tumor, it is a severe case though nanoparticles are available in abundance in the market. The problem is the absence of a substance that can control brain tumor-like glioblastoma at an earlier stage.…”

Section: Impact Of Nanoparticles On Brain Problemsmentioning

confidence: 99%

Application of Nanoparticles for Brain and Lung Cancer Therapeutics

Chen

2019

J. Drug Delivery Ther.

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Nanotechnology is and will be the future of several fields and medicine is one of them. The use of nanoparticles in the treatment of psychotic and cancer problems is analyzed in this report. Psychotic treatment has been effective due to specific nanoparticles like haloperidol and RISP, and these combinations are linked with other nanoparticles to treat other diseases. Nanoparticles have extended applications with a high degree of effectiveness to treat cancer cells due to the quick delivery, and targeted process and the same is detailed in the review sheet. Oligonucleotides combined with nanoparticles have greater efficiencies. Keywords: Nanotechnology, drug targeting, cancer treatment

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Computationally expanding infinium HumanMethylation450 BeadChip array data to reveal distinct DNA methylation patterns of rheumatoid arthritis

Abstract: Supplementary data are available at Bioinformatics online.

Cited by 26 publications

References 39 publications

Epigenetic Regulation Mediated by Methylation in the Pathogenesis and Precision Medicine of Rheumatoid Arthritis

Epigenetic Regulation Mediated by Methylation in the Pathogenesis and Precision Medicine of Rheumatoid Arthritis

Role of Inhibitors in Controlling the Diseases

Application of Nanoparticles for Brain and Lung Cancer Therapeutics

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