Computational Study on Hemoglobin Protein Family

Long-Range Correlation in Atomic Vibration οf Chicken Lysozyme Backbone

“…The results presented in this study are in good agreement with published data concerning similar studies on other proteins [10][11][12][13][14][15][16][17][18][19][20][21] and they underline the sustainability of the hypothesis that the long-range correlation in both physicochemical and dynamical properties along the chain could be a general property of proteins. It means that analysis concerning conformational changes in the protein chain in relation to the active site must take into account that the local flexibility/rigidity is strongly correlated with the flexibility or rigidity of the entire protein.…”

“…Also, the values of exponents obtained in the present study are quite higher than those obtained for the series of the B-factors values for CA atoms of CaBPs and other investigated proteins [14]. This result is not surprising because CA atoms of the constitutive amino acids of protein are not directly connected in the chain as the N, CA, C and O atoms are.…”

“…If we compare the values of the spectral and scaling exponents obtained within this study with their values obtained in the case of correlation in the flexibility and hydrophobicity/hydrophilicity along the calcium binding proteins (CaBPs) and hydrolases chains [14,15], we notice almost similar values for the spectral exponent but higher values for scaling exponent. The similarity of the spectral coefficients for the two studies are due to the fact that SA method does not allow the elimination of the non-stationary contribution within series of data.…”

“…Other studies refer to the fractal aspects of lysozymes structures regarding their surfaces [6] and backbones [7], respective the fractal structure of lysozymes aggregates [8,9]. Non-linear dynamics has been proven to apply for studies concerning the randomness of protein sequences [10][11][12][13][14][15], respective to protein folding and their conformational changes [16][17][18][19][20][21]. * corresponding author; e-mail: craciundana@gmail.com Within this study we analyze the correlation of atomic vibrations in the lysozymes main chain when it binds some ligands because this binding strongly affects the mobility of protein.…”