Computational study of cell adhesion and rolling in flow channel by meshfree method

Abstract

Tethering and rolling of circulating leukocytes on the surface of endothelium are critical steps during an inflammatory response. A soft solid cell model was proposed to study monocytes tethering and rolling behaviors on substrate surface in shear flow. The interactions between monocytes and micro-channel surface were modeled by a coarse-grained molecular adhesive potential. The computational model was implemented in a Lagrange-type meshfree Galerkin formulation to investigate the monocyte tethering and rolling process with different flow rates. From the simulation results, it was found that the flow rate has profound effects on the rolling velocity, contact area and effective stress of monocytes. As the flow rate increased, the rolling velocity would increase linearly, whereas the contact area and average effective stress in monocyte showed nonlinear increase.

Numerical investigation of the role of intercellular interactions on collective epithelial cell migration

“…All the stages of animal life, from its commencement to its end are associated with cell migration(Frascoli et al 2013; Li and Sun 2014; Lin and Zeng 2017). When cells migrate in loosely or closely associated groups, it can be referred to as collective cell migration (Li and Sun 2014; Rørth 2009 ).…”

Toward Chemotactic Supramolecular Nanoparticles: From Autonomous Surface Motion Following Specific Chemical Gradients to Multivalency-Controlled Disassembly

“…Molecular models and computer simulations are fundamental to reach this goal. Recent simulations using minimalistic coarse-grained (CG) models allowed the study of the adhesion and dynamics of nanoparticles/cells (represented as single spheres) onto ligand-functionalized surfaces. − These models permitted researchers to relate the number of interactions between the spherical nanoparticle (NP) and the surface receptors to the surface adhesion. , Similar CG models also allowed simulation and monitoring of the rolling of a deformable (soft) spherical cell model on surfaces under the presence of an external flow . Recently, the diffusion profiles of a NP (modeled as a single sphere) on a fully cross-linked membrane CG model have been largely investigated. − Specifically, variations of surface receptor density and multivalent interactions between the NPs and the gel-like membrane were observed to affect the diffusivity of the NPs, eventually inducing NP trapping in high-density regions. , Although these interesting studies provided evidence of autonomous NP movement on surfaces, finer-level molecular models are needed in the perspective of designing supramolecular assemblies ( e.g.…”

“…26,27 Similar CG models also allowed simulation and monitoring of the rolling of a deformable (soft) spherical cell model on surfaces under the presence of an external flow. 24 Recently, the diffusion profiles of a NP (modeled as a single sphere) on a fully crosslinked membrane CG model have been largely investigated. 27−29 Specifically, variations of surface receptor density and multivalent interactions between the NPs and the gel-like membrane were observed to affect the diffusivity of the NPs, eventually inducing NP trapping in high-density regions.…”

Towards Chemotactic Supramolecular Nanoparticles: From Autonomous Surface Motion Following Specific Chemical Gradients to Multivalency-Controlled Disassembly

“…Recent simulations using minimalistic coarse-grained (CG) models allowed to study the adhesion and dynamics of nanoparticles/cells (represented as single spheres) onto ligand-functionalized surfaces. [23][24][25][26] These models permitted to relate the number of interactions between the spherical nanoparticle (NP) and the surface receptors to the surface adhesion 26,27 . Similar CG models also allowed to simulate and monitor the rolling of a deformable (soft) spherical cell model on surfaces under the presence of an external flow.…”

“…Similar CG models also allowed to simulate and monitor the rolling of a deformable (soft) spherical cell model on surfaces under the presence of an external flow. 24 Recently, Debets et al simulated and analyzed the diffusion profile of a NP (modeled as a single sphere) on a fully cross-linked membrane CG model. Specifically, variations of surface receptor density and multivalent interactions between NP and gel-like membrane were observed to have remarkable effects on the diffusivity of the NP, eventually inducing NP trapping in high-density regions.…”