Computational prediction of Escherichia coli proteins host subcellular targeting and their implications in colorectal cancer etiology

Khan, Abdul Arif; Khan, Zakir; Malik, Abdul; Shrivastava, Abhinav; Jain, Shubha; Alshamsan, Aws

doi:10.1016/j.canlet.2015.04.024

Cited by 12 publications

(11 citation statements)

References 58 publications

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“…However, it is unclear whether EspF acts directly on MLH1 and MSH2 or indirectly inducing activation of some transcription factors, which down-regulate MLH1 and MSH2 expression. This hypothesis is supported by previous in vitro and in silico assays, where some nuclear targets for E. coli proteins were described (64,65). Hence, bacterial proteins could enter to cell nucleus and attach to target genes.…”

Section: Entero Pathogenic Escherichia Coli and Colon Cancersupporting

confidence: 63%

The Role of Escherichia coli in the Development and Progression of Cancer

Hernández-Luna¹,

Lagunes-Servin²,

López-Briones³

2017

ARC Journal of Cancer Science

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Section: Entero Pathogenic Escherichia Coli and Colon Cancersupporting

confidence: 63%

The Role of Escherichia coli in the Development and Progression of Cancer

Hernández-Luna¹,

Lagunes-Servin²,

López-Briones³

2017

ARC Journal of Cancer Science

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“…126 Computational prediction models suggest that 87 E. coli proteins target host cell mitochondria that contribute to the etiology of CRC. 127 SCFAs exhibit anti-tumorigenic properties in colon epithelial cells through homeostasis of mitochondrial metabolism and cell proliferation. 128 Gut bacteria have been shown to generate mutations of mtDNA and to modulate DNA repair pathways of the mitochondria.…”

Section: Gut Microbiome Signaling To Mitochondria -Ibdmentioning

confidence: 99%

Gut bacteria signaling to mitochondria in intestinal inflammation and cancer

2019

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The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the intestine as well as in the pathophysiology of diseases including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Emerging evidence suggests that gut microbiota signal to the mitochondria of mucosal cells, including epithelial cells and immune cells. Gut microbiota signaling to mitochondria has been shown to alter mitochondrial metabolism, activate immune cells, induce inflammasome signaling, and alter epithelial barrier function. Both dysbiosis of the gut microbiota and mitochondrial dysfunction are associated with chronic intestinal inflammation and CRC. This review discusses mitochondrial metabolism of gut mucosal cells, mitochondrial dysfunction, and known gut microbiota-mediated mitochondrial alterations during IBD and CRC.

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“…Previously cNLS mapper has used for the analysis of E. coli proteins targeting in mitochondria and cytoplasm of the host cells and their important role in development of colorectal cancer [ 85 ]. We utilized cNLS mapper for the analysis of nuclear localization signal (NLS) in the query protein sequence of M. hominis [ 86 ].…”

Section: Methodsmentioning

confidence: 99%

“…Recently BaCelLo ( Ba lanced Sub cel lular Lo calization) predictor has used for the prediction of E. coli proteins targeting in mitochondria and cytoplasm of the host cells and their implication in development of colorectal cancer [ 85 ]. Subcellular targeting of M. hominis proteins in the host cell was analysed by BaCelLo.…”

Section: Methodsmentioning

confidence: 99%

Prediction of mycoplasma hominis proteins targeting in mitochondria and cytoplasm of host cells and their implication in prostate cancer etiology

et al. 2016

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Although the idea of bacteria causing different types of cancer has exploded about century ago, the potential mechanisms of carcinogenesis is still not well established. Many reports showed the involvement of M. hominis in the development of prostate cancer, however, mechanistic approach for growth and development of prostate cancer has been poorly understood. In the current study, we predicted M. hominis proteins targeting in the mitochondria and cytoplasm of host cells and their implication in prostate cancer. A total of 77 and 320 proteins from M. hominis proteome were predicted to target in the mitochondria and cytoplasm of host cells respectively. In particular, various targeted proteins may interfere with normal growth behaviour of host cells, thereby altering the decision of programmed cell death. Furthermore, we investigated possible mechanisms of the mitochondrial and cytoplasmic targeted proteins of M. hominis in etiology of prostate cancer by screening the whole proteome.

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Computational prediction of Escherichia coli proteins host subcellular targeting and their implications in colorectal cancer etiology

Cited by 12 publications

References 58 publications

The Role of Escherichia coli in the Development and Progression of Cancer

The Role of Escherichia coli in the Development and Progression of Cancer

Gut bacteria signaling to mitochondria in intestinal inflammation and cancer

Prediction of mycoplasma hominis proteins targeting in mitochondria and cytoplasm of host cells and their implication in prostate cancer etiology

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