Computational optical coherence tomography [Invited]

Abstract

Optical coherence tomography (OCT) has become an important imaging modality with numerous biomedical applications. Challenges in high-speed, high-resolution, volumetric OCT imaging include managing dispersion, the trade-off between transverse resolution and depth-of-field, and correcting optical aberrations that are present in both the system and sample. Physics-based computational imaging techniques have proven to provide solutions to these limitations. This review aims to outline these computational imaging techniques within a general mathematical framework, summarize the historical progress, highlight the state-of-the-art achievements, and discuss the present challenges. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1(9), 970-972 (1995). 3. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276(5321), 2037-2039 (1997). 4. S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, "In vivo cellular optical coherence tomography imaging," Nat. Med. 4(7), 861-865 (1998). Sundaram, P. S. Ray, and S. A. Boppart, "Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery," Cancer Res. 75(18), 3706-3712 (2015). 9. J. G. Fujimoto and E. A. Swanson, "The development, commercialization, and impact of optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 57(9), OCT1-OCT13 (2016). 10. A. M. Cormack, "Representation of a function by its line integrals, with some radiological applications. II," J.Appl. Phys. 35(10), 2722-2727 (1964). 11. G. N. Hounsfield, "Computerized transverse axial scanning (tomography). 1. Description of system," Br. J.Radiol. 46(552), 1016-1022 (1973). 12. P. C. Lauterbur, "Image formation by induced local interactions: examples employing nuclear magnetic resonance," Nature 242(5394), 190-191 (1973). 13. P. T. Gough and D. W. Hawkins, "Unified framework for modern synthetic aperture imaging algorithms," Int. J.Imaging Syst. Technol. 8(4), 343-358 (1997). shaping for optimal depth-selective focusing in optical coherence tomography," Opt. Express 21(3), 2890-2902 (2013 111-115 (1962). 77. L. Cutrona, E. Leith, C. Palermo, and L. Porcello, "Optical data processing and filtering systems," IRE Trans.Inf. Theory 6(3), 386-400 (1960). 78. L. J. Cutrona, E. N. Leith, L. J. Porcello, and E. W. Vivian, "On the application of coherent optical processing techniques to synthetic-aperture radar," Proc. IEEE 54(8), 1026-1032 (1966). 79. W. Brown and L. Porcello, "An introduction to synthetic-aperture radar," IEEE Spectr. 6(9), 52-62 (1969). 80. M. P. Hayes and P. T. Gough, "Broad-band synthetic aperture sonar," IEEE J. Oceanic Eng. 17(1), 80-94 (1992)

Optical Coherence Tomography (OCT): Principle and Technical Realization

“…With this method in principal also the defocus caused by the Gaussian beam profile along the z-axis can be numerically compensated. For more details the reader may refer to the references [34][35][36].…”

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis

“…Optical coherence tomography (OCT) is a high resolution imaging technique suitable for sophisticated post-processing 1,2 . Since our last metaanalysis 3 time domain (TD-) retinal OCT has been overtaken by spectral domain (SD-) OCT in clinical practise 4 .…”

Blur resolved OCT: full-range interferometric synthetic aperture microscopy through dispersion encoding

“…Optical coherence tomography (OCT) offers high resolution non-invasive imaging of tissues and other semitransparent materials Huang et al (1991); Fujimoto et al (2000); Tomlins and Wang (2005); Liu et al (2017). Through the reflection interference between a reference and sample arm, the structure of scatterers along depth are encoded.…”