Computational models of myocardial endomysial collagen arrangement

Intrigila, Benedetto; Melatti, Igor; Tofani, Alberto; Macchiarelli, Guido

doi:10.1016/j.cmpb.2007.03.004

Cited by 12 publications

(16 citation statements)

References 12 publications

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“…Our results showed that the endomysial wall collagen fibers have architectural structural arrangement in form of an irregular network of a single layer in normal dogs (Benedicto and Bombonato, 2003;Anderson et al, 2005;Intrigila et al, 2007;Macchiarelli et al, 2002). In aged and diabetic dogs this net remolds acquiring bigger fibers amount and layers becoming a fibers carpet modifying the relations of tension/ strenght of the tissue.…”

Section: Discussionmentioning

confidence: 73%

“…The cardiac collagen matrix is composed by endomysial collagen that connects myocytes and surrounds, in amesh-like structure, the myocytes themselves and perimysial collagen that groups myocytes together, running in parallel with myofibrils and linking itself to endomysial collagen (Intrigila et al, 2007;Janicki et al, 1995;Leite et al, 2004;Macchiarelli et al, 2002;Robinson et al, 1983). So that collagen fibers of excessive thickness could interfere with the normal mechanics of the myocytes themselves (both in the passive and active phase).…”

Section: Discussionmentioning

confidence: 94%

“…The overall arrangement is for the myocytes to be supported as the muscular components of a continuous and complex mass, the supporting collagenous fibrous matrix possessing epimysial, perimysial, and endomysial components (Anderson et al, 2005;Borg and Caufield, 1981;Borg et al, 1982). In particular, endomysial collagen contribution to the passive mechanics of cardiac muscle as well as its micro anatomical arrangement is still a matter of debate (Intrigila et al, 2007). The main types of collagen in the interstice of the myocardium are I, III, and V. The collagen is the most prevalent protein in the vertebrates constitutes approximately one forth of the total body proteins of the adult organisms.…”

Section: Introductionmentioning

confidence: 99%

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Structural arrangement of the cardiac collagen fibers of healthy and diabetic dogs

Benedicto

Bombonato

Macchiarelli

et al. 2011

Microscopy Res & Technique

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The heart is composed by a specialized muscle, whose form and function are essentials for an adequate work and shows an amount of connective tissue which support and provide insertion for this muscle, whose collagen fibers are responsible for determination of tissue feature. Our objective was to identify the structural arrangement of the heart collagen fibers in dogs. The hearts of the dogs were submitted to the process of the controlled digestion with NaOH solution and observed by scanning electron microscope. Our results showed that the collagen fibers of the endomysial wall have structural arrangement composed by an irregular network with one layer in normal dogs but in diabetic dogs the network acquires a greater amount of the fibers and layers, looking like a "rug" of fibers modifying the relationships of the stress/strain of the tissue. Ahead of the observed results we are able to conclude that exist increase in the amount and thickness of cardiac collagen fibers, beyond the increase of layers and architectural disarrangement in the endomysial wall in the diabetic dogs.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Structural arrangement of the cardiac collagen fibers of healthy and diabetic dogs

Benedicto

Bombonato

Macchiarelli

et al. 2011

Microscopy Res & Technique

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“…Consequently, lattice models are able to capture mechanical events related to the discreteness of the structures they represent. One can think here of the nucleation of a single dislocation in metals (Tadmor et al, 1996a,b;Shenoy et al, 1999;Eidel and Stukowski, 2009), the failure of an individual fiber-to-fiber bond in collagen networks (Intrigila et al, 2007) or in paper materials (Kulachenko and Uesaka, 2012;Wilbrink et al, 2013) and the failure of a conductive wire in an electronic textile (Beex et al, 2013a).…”

Section: Introductionmentioning

confidence: 99%

Quasicontinuum-based multiscale approaches for plate-like beam lattices experiencing in-plane and out-of-plane deformation

Beex

Kerfriden

Rabczuk

et al. 2014

Computer Methods in Applied Mechanics and Engineering

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The quasicontinuum (QC) method is a multiscale approach that aims to reduce the computational cost of discrete lattice computations. The method incorporates smallscale local lattice phenomena (e.g. a single lattice defect) in macroscale simulations. Since the method works directly and only on the beam lattice, QC frameworks do not require the construction and calibration of an accompanying continuum model (e.g. a cosserat/micropolar description). Furthermore, no coupling procedures are required between the regions of interest in which the beam lattice is fully resolved and coarse domains in which the lattice is effectively homogenized. Hence, the method is relatively straightforward to implement and calibrate. In this contribution, four variants of the QC method are investigated for their use for planar beam lattices which can also experience out-of-plane deformation. The different frameworks are compared to the direct lattice computations for three truly multiscale test cases in which a single lattice defect is present in an otherwise perfectly regular beam lattice.

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“…They are typically used to model biological materials (Arnoux et al, 2002;Chandran and Barocas, 2006;Stylianopoulos and Barocas, 2007;Intrigila et al, 2007;Argento et al, 2012), paper networks (Bronkhorst, 2003;Batchelor, 2008;Liu et al, 2010;Strömbro and Gudmundson, 2008;Kulachenko and Uesaka, 2012) and textiles (Kato et al, 1997;Sharma and Sutcliffe, 2004;Zohdi and Powell, 2006;Ben Boubaker, 2007a,b;Beex et al, 2012b). The discrete elements in lattice models naturally represent the discrete fibers and yarns of these materials.…”

Section: Introductionmentioning

confidence: 99%

A multiscale quasicontinuum method for lattice models with bond failure and fiber sliding

Beex

Peerlings

Geers

2014

Computer Methods in Applied Mechanics and Engineering

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Structural lattice models incorporating trusses and beams are frequently used to mechanically model fibrous materials, because they can capture (local) mesoscale phenomena. Physically relevant lattice computations are however computationally expensive. A suitable multiscale approach to reduce the computational cost of large-scale lattice computations is the quasicontinuum (QC) method. This method resolves local mesoscale phenomena in regions of interest and coarse grains elsewhere, using only the lattice model. In previous work, a virtual-power-based QC framework is proposed for lattice models that include local dissipative mechanisms. In this paper, the virtualpower-based QC method is adopted for lattice models in which bond failure and subsequent frictional fiber sliding are incorporated -which are of significant importance for fibrous materials such as paper, cardboard, textile and electronic textile. Bond failure and fiber sliding are nonlocal dissipative mechanisms and to deal with this nonlocality, the virtual-power-based QC method is equipped with a mixed formulation in which the kinematic variables as well as the internal history variables are interpolated. Previously defined summation rules can still be used to sample the governing equations in this QC framework. Illustrative examples are presented.

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Computational models of myocardial endomysial collagen arrangement

Cited by 12 publications

References 12 publications

Structural arrangement of the cardiac collagen fibers of healthy and diabetic dogs

Structural arrangement of the cardiac collagen fibers of healthy and diabetic dogs

Quasicontinuum-based multiscale approaches for plate-like beam lattices experiencing in-plane and out-of-plane deformation

A multiscale quasicontinuum method for lattice models with bond failure and fiber sliding

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