Computational Models of Interoception and Body Regulation

Petzschner, Frederike H.; Garfinkel, Sarah N.; Paulus, Martin P.; Koch, Christof; Khalsa, Sahib S.

doi:10.1016/j.tins.2020.09.012

Cited by 123 publications

(122 citation statements)

References 104 publications

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“…III Therefore, agents actively infer their own volatility trajectories, in part, by sampling and controlling interoceptive rhythms, resulting in close coupling between top-down expected volatility and the visceral body [14,34,128].…”

Section: Interoceptive Self-inference: An Integrated Theory Of Consciousness?mentioning

confidence: 99%

What might interoceptive inference reveal about consciousness?

Nikolova¹,

Waade²,

Friston³

et al. 2021

Preprint

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The mainstream science of consciousness offers a few predominate views of how the brain gives rise to awareness. Chief among these are the Higher Order Thought Theory, Global Neuronal Workspace Theory, Integrated Information Theory, and hybrids thereof. In parallel, rapid development in predictive processing approaches have begun to outline concrete mechanisms by which interoceptive inference shapes selfhood, affect, and exteroceptive perception. Here, we consider these new approaches in terms of what they might offer our empirical, phenomenological, and philosophical understanding of consciousness and its neurobiological roots.

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Section: Interoceptive Self-inference: An Integrated Theory Of Consciousness?mentioning

confidence: 99%

What might interoceptive inference reveal about consciousness?

Nikolova¹,

Waade²,

Friston³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Once a change in physiological state (e.g., hunger) is signaled, the caregiver’s job is to recognize the infant’s cues and respond with a specific behavior (e.g., feeding or changing a diaper) to meet the infant’s needs. Through gradual but constant adjustments, the behaviors put in place within these interactions contribute to the infant’s ability to dynamically anticipate perturbations and achieve long‐term stability (i.e., allostasis; Petzschner et al., 2021; Sterling, 2012).…”

mentioning

confidence: 99%

Being in Tune With Your Body: The Emergence of Interoceptive Processing Through Caregiver–Infant Feeding Interactions

Filippetti

2021

Child Dev Perspectives

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Interoception—the ability to perceive and respond to internal bodily sensations—is fundamental for the continuous regulation of physiological processes. Recently, it has been suggested that because infants depend completely on their caregivers for survival, the development of interoceptive processing emerges as a result of early dyadic interactions, and relies on caregivers’ ability to respond to and meet infants’ physiological needs. In this article, I examine how both caregivers’ and infants’ own characteristics contribute to the emergence and development of infants’ interoceptive processing. In particular, by focusing on feeding interactions, I suggest that infants build expectations about the cause of their internal sensations via a dynamic process of interoceptive distinction between self and other. This developmental account provides a framework that considers the complexity of early dyadic exchanges, and offers novel hypotheses for research investigating the mechanisms involved in the ontogeny of interoceptive processing and eating behaviors.

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“…(41,44)). Another promising future direction could be to combine this paradigm with more sophisticated computational modelling approaches, which is an area of interoception research that has been substantially limited by a lack of compatible tools (5,6).…”

Section: Discussionmentioning

confidence: 99%

“…Interoception, the process by which the nervous system senses, interprets, and integrates signals originating from within the body across conscious and nonconscious levels (1), is a vital component of this homeostatic machinery maintaining internal stability in the face of changing environments. However, interoception remains poorly understood despite both growing scientific interest (2)(3)(4)(5) and the recognition that certain psychiatric (6) and neurological (7,8) disorders may manifest through abnormal neural processing of interoceptive signals.…”

Section: Introductionmentioning

confidence: 99%

Neural indicators of human gut feelings

Mayeli

et al. 2021

Preprint

Self Cite

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Understanding the neural processes that govern the human gut-brain connection has been challenging due to the inaccessibility of the body′s interior. In this study, we aimed to identify neural responses to gastrointestinal sensation (i.e., the neural basis of ′gut feelings′) in healthy humans using a minimally invasive mechanosensory probe. Combining electroencephalography and electrogastrography with signal detection theory measures, we quantified brain, stomach, and perceptual (button-press) responses following the ingestion of a vibrating capsule. The relationship between vibration strength and perceptual sensitivity was evaluated using two stimulation conditions (normal and enhanced). Most individuals successfully perceived capsule stimulation in both conditions, as evidenced by above chance accuracy scores. Perceptual accuracy improved significantly during the enhanced relative to normal stimulation, which was associated with faster reaction time and reduced reaction time variability. Stomach stimulation induced responses in a cluster of parieto-occipital leads near the midline via a late positive potential emerging 300-600 milliseconds after stimulation onset. Moreover, these ′gastric evoked potentials′ showed dose-dependent increases in amplitude and were significantly correlated with perceptual accuracy. Our findings are consistent with recent neurogastric and optogenetic studies demonstrating a role for posteromedial cortices in gastrointestinal interoception and body dissociation and highlight a unique form of enterically-focused sensory monitoring within the human brain. Overall, these results show that this minimally invasive approach could serve as a useful tool for understanding gut-brain interactions in healthy and clinical populations.

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Computational Models of Interoception and Body Regulation

Cited by 123 publications

References 104 publications

What might interoceptive inference reveal about consciousness?

What might interoceptive inference reveal about consciousness?

Being in Tune With Your Body: The Emergence of Interoceptive Processing Through Caregiver–Infant Feeding Interactions

Neural indicators of human gut feelings

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