Computational modelling of epithelial to mesenchymal transition

Abdulla, Tariq; Imms, Ryan; Dillenseger, Jean-Louis; Schleich, Jean-Marc; Summers, Ron

doi:10.1016/j.irbm.2011.09.001

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…145 Albeit generally controlled by the expression of one or multiple genes, they introduce relevant epigenetic interactions beyond the gene level, key to the establishment of functional structures. In particular, one of the most well documented examples, also related to our proposed liquid-solid dichotomy, is the epithelial-mesenchymal transition (hereafter EMT) 256,267 (Fig. 8b).…”

Section: Physical State Related Modelsmentioning

confidence: 71%

A morphospace for synthetic organs and organoids: the possible and the actual

et al. 2016

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Efforts in evolutionary developmental biology have shed light on how organs are developed and why evolution has selected some structures instead of others. These advances in the understanding of organogenesis along with the most recent techniques of organotypic cultures, tissue bioprinting and synthetic biology provide the tools to hack the physical and genetic constraints in organ development, thus opening new avenues for research in the form of completely designed or merely altered settings. Here we propose a unifying framework that connects the concept of morphospace (i.e. the space of possible structures) with synthetic biology and tissue engineering. We aim for a synthesis that incorporates our understanding of both evolutionary and architectural constraints and can be used as a guide for exploring alternative design principles to build artificial organs and organoids. We present a three-dimensional morphospace incorporating three key features associated to organ and organoid complexity. The axes of this space include the degree of complexity introduced by developmental mechanisms required to build the structure, its potential to store and react to information and the underlying physical state. We suggest that a large fraction of this space is empty, and that the void might offer clues for alternative ways of designing and even inventing new organs.

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Section: Physical State Related Modelsmentioning

confidence: 71%

A morphospace for synthetic organs and organoids: the possible and the actual

et al. 2016

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“…When Notch intra is absent the target cell is repressed which leads to lateral inhibition ( Figure 1a); but in its presence the target cell is activated which leads to lateral induction (Figure 1b). c Figure 1: a) schematic diagram of lateral inhibition [6]; b) schematic diagram of lateral induction [6]; c) Sensory hair patches in a chick's inner ear [7].…”

Section: Biological Contextmentioning

confidence: 99%

“…Previous work by the research team at Loughborough University has investigated the link between multi-scale functions and behaviour in the development of heart tissue using an ontological approach [3] and more specifically epithelial to mesenchymal transition in cardiac cushion growth in the development of heart valves [4,5]. In the latter studies, the role of the trans-membrane protein Delta-Notch cell signalling network is particularly important.…”

Section: Introductionmentioning

confidence: 99%

Delta-Notch Lateral Inhibition within the Organ of Corti

Summers

Abdulla

Luff

2013

J. Phys.: Conf. Ser.

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Abstract. Lateral inhibition is described as an emergent property of the Delta-Notch signalling network. Two separate model representations of lateral inhibition are proposed for different purposes. One provides information about bioenergetics while the other has the capability to produce a physical representation. It is proposed that both can be used in further studies of the sensory pathways in the human connectome model of brain function.

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