“…Bona fide iPSCs are, like murine embryonic stem cells (ESCs), competent to form blastocyst chimaeras and are considered to occupy a state of naïve pluripotency similar to that in the pre-implantation embryo Boroviak et al, 2015). Experimental and computational efforts have led to circuitry mapping of the core TF program that maintains ESC self-renewal under defined conditions (Chen et al, 2008;Niwa et al, 2009;MacArthur et al, 2012;Dunn et al, 2014;Herberg & Roeder, 2015;Rue & Martinez Arias, 2015;Yachie-Kinoshita et al, 2018). Experimental and computational efforts have led to circuitry mapping of the core TF program that maintains ESC self-renewal under defined conditions (Chen et al, 2008;Niwa et al, 2009;MacArthur et al, 2012;Dunn et al, 2014;Herberg & Roeder, 2015;Rue & Martinez Arias, 2015;Yachie-Kinoshita et al, 2018).…”